DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and Sox12

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_035568.1	Gene:	Sox12 / 20667	MGIID:	98360	Length:	314	Species:	Mus musculus

Alignment Length:	200	Identity:	66/200 - (33%)
Similarity:	88/200 - (44%)	Gaps:	55/200 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 VNSCGTNSERSAALDPESLNSGQLGPVPASPSSQP---LRQGNGHGHGGNHGHVHSKPHIKRPMN 428
            |...|..::|.....|.       ||.||:..::.   .:..:|              |||||||
Mouse     2 VQQRGARAKRDGGPPPP-------GPGPAAEGAREPGWCKTPSG--------------HIKRPMN 45

  Fly   429 AFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYR 493
            |||||::.|||||:...|||||:.|||.||.||:.:.:::|.|:..|..||...||..:|||:||
Mouse    46 AFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYR 110

  Fly   494 PRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGS-----------GSLCADACPK 547
            ||         ||.:.:..|...|           ..||..|||           |...|...|.
Mouse   111 PR---------KKSKGAPAKARPR-----------PPGGGGGGSRLKPGPQLPGRGGRRASGGPL 155

  Fly   548 GSGGS 552
            |.|.:
Mouse   156 GGGAA 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	39/70 (56%)
Sox12	NP_035568.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/58 (16%)
		SOX-TCF_HMG-box	39..110	CDD:238684	39/70 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..287		22/79 (28%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269\|PubMed:18403418	282..314
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830