DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SOX30

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_848511.1	Gene:	SOX30 / 11063	HGNCID:	30635	Length:	753	Species:	Homo sapiens

Alignment Length:	438	Identity:	99/438 - (22%)
Similarity:	152/438 - (34%)	Gaps:	120/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 PQHQNQQAVSVSS-GNLMPFLP--AFLQPPMPNAQQLLQLIPGHENAQSVPTHHHSHPQSEAFST 146
            ||.||::|.:.|: ..|:.|.|  ..||||..:           :.|.|.|..|...|.:.....
Human    84 PQAQNEEAAASSAQARLLQFRPDLRLLQPPTAS-----------DGATSRPELHPVQPLALHVKA 137

  Fly   147 HKMALAPMWSTAAVAAAHIQAALAAAAVAAANN-NKNSSHFSNNTNIVGLATRGNELLNTDSDPQ 210
            .|..|.|....:......::....|:.|..... .....:|           ||:|....:::..
Human   138 KKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYF-----------RGDEKGKLEAEEV 191

  Fly   211 MEIGETRRGGNGGSCRSRPESPTYENPPYEILSYSHNTPPESPHGRTADCSKNFSPSPTDNLSIA 275
            |.  ::.:||.|.|..:..|.......|..:|.               ||  .....|..|..:.
Human   192 MR--DSMQGGAGKSPAAIREGVIKTEEPERLLE---------------DC--RLGAEPASNGLVH 237

  Fly   276 SVSEAQDSEMDAPLNLSKPKGSPSSSPNSSSQRDHCENLTPVVSSPPLSWHQGQPHYAEIELPL- 339
            ..:|                                      |...|.|...| ||..::.:||
Human   238 GSAE--------------------------------------VILAPTSGAFG-PHQQDLRIPLT 263

  Fly   340 ---LKSHGRVWNSAVACSGGSRATRVSRDSVNSCGTNSERSAALDPESLNSGQLGPVPASPSSQP 401
               :....|:.......|...|.|:|....|     .::..:.|:|......:..|:...||...
Human   264 LHTVPPGARIQFQGAPPSELIRLTKVPLTPV-----PTKMQSLLEPSVKIETKDVPLTVLPSDAG 323

  Fly   402 L------RQGNGHGHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGAR 460
            :      :..||              |:|||||||||||:..|..:.||.|..:|:.||..||..
Human   324 IPDTPFSKDRNG--------------HVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLE 374

  Fly   461 WKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMR 508
            |..:|...|:|||:|..::.:.|.|:.|.:.|:|||       ||:.|
Human   375 WNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRP-------GKRKR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	31/70 (44%)
SOX30	NP_848511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..161		3/23 (13%)
		SOX-TCF_HMG-box	336..406	CDD:238684	31/69 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..753
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810