DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and FOXH1

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_003914.1	Gene:	FOXH1 / 8928	HGNCID:	3814	Length:	365	Species:	Homo sapiens

Alignment Length:	203	Identity:	59/203 - (29%)
Similarity:	87/203 - (42%)	Gaps:	44/203 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PQTQRIFQP---------EEPKPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPG 172
            |:.:...||         ...||.::|:.:||:.|.::...:|.|:.|.:.:...:|:||....|
Human    12 PEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEG 76

  Fly   173 WRNSIRHNLSLNDCFIKSGR---SANGKGHYWAIH----PANMEDFRKGDFRRR----KAQRKVR 226
            |::|||||||.|.||.|..:   ....||::||:.    ||.....:.....||    .|:....
Human    77 WKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFA 141

  Fly   227 KHMGLSVDDASTDSPSPPPLDLTTPPPPSS----QSALQLSALGYPYHQHYIGQFFNRSSAPGMT 287
            |.:|..|   ....|..||   :.|||||.    :|.|..|..|.|:              ||:.
Human   142 KDLGPYV---LHGRPYRPP---SPPPPPSEGFSIKSLLGGSGEGAPW--------------PGLA 186

  Fly   288 HYSPPDPA 295
            ..|.|.||
Human   187 PQSSPVPA 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	31/90 (34%)
FOXH1	NP_003914.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		3/16 (19%)
		FH	33..111	CDD:238016	29/77 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..215		19/61 (31%)
		SMAD-interaction domain (SID)	273..354
		Fast/FoxH1 motif 1 (FM1)	277..281
		Fast/FoxH1 motif 2 (FM2)	287..293
		SMAD interaction motif (SIM)	327..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820