DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and foxk2b

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_001922856.1	Gene:	foxk2b / 798356	ZFINID:	ZDB-GENE-030131-5310	Length:	597	Species:	Danio rerio

Alignment Length:	585	Identity:	139/585 - (23%)
Similarity:	220/585 - (37%)	Gaps:	149/585 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PLGTTRTSQAQSTTMTLEQYRLQLYNYALNIERLRCPQYGGTGGSGA--SAPWLHLSPYGHHGSG 99
            |....:..|.|.:.:|:        |...||..|..|....||...|  |.|   .||.|...||
Zfish   122 PESPVKAVQPQISPLTI--------NIPDNIAHLMSPLPSPTGTISAANSCP---SSPRGAGSSG 175

  Fly   100 -----SLPSVNRMAALSTISLFPQTQRIFQP-EEPKPQHSYIGLIAMAILSSTDMKLVLSDIYQY 158
                 .:|.:..|...|......:|.....| ::.||.:||..||..||..:.|.:|.|:.||.:
Zfish   176 YRLGRIVPDLQLMNDNSQSENDKETSEGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTH 240

  Fly   159 ILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGRSAN--GKGHYWAIHPANMEDFRKGDFRRRKA 221
            |..||||:|:...||:||||||||||..|||..||..  |||.:|.|.|::.....:..||:|:
Zfish   241 ITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPSSEGKLVEQAFRKRR- 304

  Fly   222 QRKVRKHMGLSVDDASTDSPSPPPLDLTTPPPPSSQSALQLSALGYPYHQHYIGQFFNRSSAPGM 286
                               |...|...|...|.||:||        |...::.|.....||.
Zfish   305 -------------------PRGVPCFRTPLGPLSSRSA--------PASPNHSGVLSAHSSG--- 339

  Fly   287 THYSPPDPALLMQRQEANNLDQTIQPTQLQQPHSHHQHFAYINSTTTTTIANMFSQTRKRQFDVA 351
              ...||..    .:|.:.:....:|..:..|               ..:|             .
Zfish   340 --VQTPDSL----SREGSPVPMESEPVSVPPP---------------AAVA-------------V 370

  Fly   352 SLLAPDVQIVDIVSEDQESSVTP-TTSARTTTQTHHTVITKQTIHREVVLGLEKPVQDADIDADI 415
            :.:.|.:.::      ||:..|. ||::..|||             .|::.:::|:..
Zfish   371 AAVQPKLAVI------QETRFTQNTTASPITTQ-------------PVLIAVQRPLTQ------- 409

  Fly   416 DVEVNVDVVDDSIIPDTDSYTDGEDRKKTRGTLKQIFSIEDNNSYLIDGRLSSFDADPDHDPDHD 480
                |:..|..::.....|.|..:...:|...:.||.::          .:|:...:|..:.|:|
Zfish   410 ----NMKPVTYAVAAPVSSSTSAQPLMQTVHVVHQIPAV----------AVSTVKTEPRENGDYD 460

  Fly   481 PEDLEQHNFSIASSAARSLGSSSSQHEESSSLEECPIQECIVAPQTALISSMATAKTSTLS---- 541
              :|:....::...|..|:|:::...:.|::  ..|:|...:..|..|.......||.|.:
Zfish   461 --ELKVKVEAVPGIAHGSIGTANRVIQTSAA--ATPLQTVTIVQQAPLGQHQLPIKTITQNGTHV 521

  Fly   542 VPISDA-YLELNQVDQ--HMLSRYYGSYIAAAARRASIDASNTSRTSSITPPP----KIEILSQK 599
            |||:.| ..:.|.|..  |:|:       |.|:..||:.....:...:..||.    |.|...||
Zfish   522 VPIATAIQSQANTVSSPLHLLA-------AHASASASLPTKRQNGEKASDPPESKRLKTEDEEQK 579

Fly 600 599
Zfish 580 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	42/85 (49%)
foxk2b	XP_001922856.1	FHA	17..109	CDD:238017
foxk2b	XP_001922856.1	Forkhead	211..297	CDD:278670	42/85 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850