DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and Foxk2

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_011247520.1	Gene:	Foxk2 / 68837	MGIID:	1916087	Length:	690	Species:	Mus musculus

Alignment Length:	434	Identity:	126/434 - (29%)
Similarity:	165/434 - (38%)	Gaps:	131/434 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KPSLPNIYPLGTTRTSQAQSTTMTLEQYRLQLYNYALNIERLRCPQYGGTGGSGASAPWLHLSPY 93
            ||..|:|.||           |:.:......|      |..|..|.  ||..:..|.|   .||.
Mouse   203 KPVQPHISPL-----------TINIPDTMAHL------ISPLPSPT--GTISAANSCP---SSPR 245

  Fly    94 GHHGSGSLPSVNRMAALSTISLFPQTQRIFQPE-------------EPKPQHSYIGLIAMAILSS 145
            |...||.  .|.|:.. |.:||.....   |||             :.||.:||..||..||..:
Mouse   246 GAGSSGY--KVGRVMP-SDLSLMADNS---QPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMA 304

  Fly   146 TDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGRSAN--GKGHYWAIHPANM 208
            .|.:|.|:.||.:|..||||:|:...||:||||||||||..|||..||..  |||.:|.|.||:.
Mouse   305 PDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASE 369

  Fly   209 EDFRKGDFRRRK--------------AQRKV---RKHMG-LSVDDASTDSP-------SPPPLDL 248
            ....:..||:|:              :.|..   ..|.| ||...:...:|       ||.||:
Mouse   370 SKLVEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLE- 433

  Fly   249 TTPPPPSSQSALQLSALGYPYHQHYIGQFFNRSSAPGMTHYSPPDPALLMQRQEANNLDQTIQPT 313
              |.|.:||..|.:           |.:.....||||....|.| ..:.:|||    |...|:|
Mouse   434 --PEPGASQPKLAV-----------IQEARFAQSAPGSPLSSQP-VLITVQRQ----LPPAIKP- 479

  Fly   314 QLQQPHSHHQHFAYINSTTTTTIANMFSQTRKRQFDVASLLAPDVQIVDIVSEDQESSVTPTTS- 377
                          :..|..|.:....||            .|.||.|.:|.:....|||....
Mouse   480 --------------VTYTVATPVTTPTSQ------------PPVVQTVHVVHQIPAVSVTSVAGL 518

  Fly   378 --ARTTTQTHHTVITKQTI-------------HREVVLGLEKPV 406
              |.|.|.....|:|:..:             ||||.:.:| ||
Mouse   519 APANTYTVAGQAVVTQAAVLAPPNPEPQENGDHREVRVKVE-PV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	43/85 (51%)
Foxk2	XP_011247520.1	FHA	41..>124	CDD:238017
		COG5025	<175..>381	CDD:227358	73/205 (36%)
		Forkhead	287..373	CDD:365978	43/85 (51%)
		PHA03247	<380..683	CDD:223021	53/229 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850