DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd102C and Foxo1

DIOPT Version :10

Sequence 1:NP_651951.1 Gene:fd102C / 43843 FlyBaseID:FBgn0039937 Length:599 Species:Drosophila melanogaster
Sequence 2:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus


Alignment Length:546 Identity:125/546 - (22%)
Similarity:199/546 - (36%) Gaps:169/546 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 GASAPWLHLSPYGHHGSGSL---PSVNRMAALSTISLFPQTQRIFQPEEPKPQH-------SYIG 136
            |..|..:|.:|.....:|.|   |.|...||.:...|      ..||.:.....       ||..
Mouse   106 GPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAAGPL------AGQPRKTSSSRRNAWGNLSYAD 164

  Fly   137 LIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRG-----PGWRNSIRHNLSLNDCFIKSGRSANG 196
            ||..||.||.:.:|.||.||::::.:.|||:.:|     .||:|||||||||:..||:......|
Mouse   165 LITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTG 229

  Fly   197 KGHYWAIHPANMEDFRKGDFRRRKA-----QRKVRKHMGLSV-DDASTDSPSPPPLDLTTPPPPS 255
            |..:|.::|   |..:.|...||:|     ..|..|..|.:. ..||..|....|.|     .|.
Mouse   230 KSSWWMLNP---EGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGD-----SPG 286

  Fly   256 SQSALQLSALGYPYHQHYIGQFFNRSSAPGMTHYSPPDPALLMQRQEANNLDQTIQPTQLQQPHS 320
            |                   ||....::|| :|          ...:.:|. .|.:|.       
Mouse   287 S-------------------QFSKWPASPG-SH----------SNDDFDNW-STFRPR------- 313

  Fly   321 HHQHFAYINSTTTTTIANMFSQTRKRQ-----FDVASLLAPD-----VQIVDIVSE--------- 366
                    .|:..:||:...|.....|     .||.||:.|.     ...:..:||         
Mouse   314 --------TSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMEN 370

  Fly   367 --DQESSVTPTTSARTTTQTHHTVITKQTIHREVVLGLEKPVQDADIDADIDVEVNVDVVDDSII 429
              |..:.::..||...:||:....:.:||           |....   |..:..:|      |..
Mouse   371 LLDNLNLLSSPTSLTVSTQSSPGSMMQQT-----------PCYSF---APPNTSLN------SPS 415

  Fly   430 PDTDSYTDGEDRKKTRGTLKQ--IFSIEDN-NSYLIDGRLSSFDADP---------DHDPDHD-- 480
            |:...||.|:   .:...|.|  :.:::|: :||   |.|:.::..|         |..|.:|  
Mouse   416 PNYSKYTYGQ---SSMSPLPQMPMQTLQDSKSSY---GGLNQYNCAPGLLKELLTSDSPPHNDIM 474

  Fly   481 -PED----------LEQHNFSIASSAARSLGSSSSQH--------------EESSSLEECPIQEC 520
             |.|          |.|:.....:|...:.||.:|.:              ::::|:....:...
Mouse   475 SPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMMNPSSHTHPGHAQQTASVNGRTLPHV 539

  Fly   521 I-VAPQTALISSMATAKTSTLSVPIS 545
            : ..|.|:.::.:...|| .|.||:|
Mouse   540 VNTMPHTSAMNRLTPVKT-PLQVPLS 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd102CNP_651951.1 FH_FOXQ2-like 129..223 CDD:410809 39/110 (35%)
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 11/47 (23%)
FH_FOXO1 148..246 CDD:410834 36/100 (36%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 32/164 (20%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 1/1 (100%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 64/359 (18%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 24/121 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 7/40 (18%)
FOXO_KIX_bdg 420..501 CDD:465228 19/86 (22%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 0/3 (0%)
FOXO-TAD 594..630 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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