DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and FOXC2

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_005242.1	Gene:	FOXC2 / 2303	HGNCID:	3801	Length:	501	Species:	Homo sapiens

Alignment Length:	284	Identity:	84/284 - (29%)
Similarity:	114/284 - (40%)	Gaps:	102/284 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 YGG---------------TGGSGASAPWLHLSPYGHHGSGSLPSVNRMAALSTISLFPQTQRIFQ 124
            |||               :.|.|.|     .:||.||                           |
Human    31 YGGMASPMGVYSGHPEQYSAGMGRS-----YAPYHHH---------------------------Q 63

  Fly   125 PEEP----KPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLND 185
            |..|    ||.:|||.||.|||.::.:.|:.|:.|||:|:|.:|::|....||:||||||||||:
Human    64 PAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNE 128

  Fly   186 CFIKSGRSAN--GKGHYWAIHPANMEDFRKGDFRRRK---------AQRKVRKHMGLSVDDASTD 239
            ||:|..|...  |||.||.:.|.:...|..|.|.||:         .:::.|.|:......||..
Human   129 CFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEPPPAASKG 193

  Fly   240 SPSPPPL---------------DLTTPPPP--------SSQSALQLSALGYPYHQHYIGQFFNRS 281
            :|:.|.|               :..:|..|        |.:||||    |.|           ||
Human   194 APATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQ----GSP-----------RS 243

  Fly   282 SAPGMTHYSPPDPALLMQRQEANN 305
            :|  .|....||.:|......|.|
Human   244 AA--STPAGSPDGSLPEHHAAAPN 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	42/85 (49%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	42/87 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..208		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..268		16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920