DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and FOXD1

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_004463.1	Gene:	FOXD1 / 2297	HGNCID:	3802	Length:	465	Species:	Homo sapiens

Alignment Length:	288	Identity:	82/288 - (28%)
Similarity:	114/288 - (39%)	Gaps:	113/288 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GGTGGSGASAPWLHLSPYGHHGSGSLPSVNRMAALSTISLFPQTQRIFQPEEP--KPQHSYIGLI 138
            ||.||.||...       |..|||:                         :.|  ||.:|||.||
Human   102 GGGGGGGAGGG-------GSAGSGA-------------------------KNPLVKPPYSYIALI 134

  Fly   139 AMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGRSAN--GKGHYW 201
            .||||.|...:|.||:|.::|...:||:|.:.|.|:|||||||||||||:|..|...  |||:||
Human   135 TMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYW 199

  Fly   202 AIHPANMEDFRKGDFRRRKAQRKVRKHMGLSVDDASTDS-----------------------PSP 243
            .:.|.:.:.|..|.|.||:  ::.::...|..:.|:.:|                       |:|
Human   200 TLDPESADMFDNGSFLRRR--KRFKRQPLLPPNAAAAESLLLRGAGAAGGAGDPAAAAALFPPAP 262

  Fly   244 PP---------------LDL--------------------------TTPPPPSSQSALQLSALGY 267
            ||               |.|                          ..||||...:|.:|:...:
Human   263 PPPPHAYGYGPYGCGYGLQLPPYAPPSALFAAAAAAAAAAAFHPHSPPPPPPPHGAAAELARTAF 327

  Fly   268 PYHQHYIGQFFNRSSAPGMTHYSPPDPA 295
            .|..|.:|     ::.||      |.||
Human   328 GYRPHPLG-----AALPG------PLPA 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	44/85 (52%)
FOXD1	NP_004463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		7/21 (33%)
		Forkhead	125..211	CDD:278670	44/85 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820