DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd102C and FOXC1

DIOPT Version :9

Sequence 1:NP_651951.1 Gene:fd102C / 43843 FlyBaseID:FBgn0039937 Length:599 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:318 Identity:94/318 - (29%)
Similarity:129/318 - (40%) Gaps:75/318 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 PQYGG----------TGGSGASAPWLHLSPYGH--HGSGSLPSVNRMAALSTISLFPQTQRIFQP 125
            |..||          ..|.|.:|....:|.|.|  |.......:.|.....|    ||.    ||
Human    17 PYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGMARAYGPYT----PQP----QP 73

  Fly   126 EE-PKPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIK 189
            :: .||.:|||.||.|||.::.|.|:.|:.|||:|:|.:|::|....||:||||||||||:||:|
Human    74 KDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVK 138

  Fly   190 SGRSAN--GKGHYWAIHPANMEDFRKGDFRRRK-----------AQRKVRKHM------GLSVD- 234
            ..|...  |||.||.:.|.:...|..|.|.||:           .:.|.|.|:      |.... 
Human   139 VPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPP 203

  Fly   235 ------DASTDSPSPPPLDL--------TTPPPP---------SSQSALQLSALGYPYHQHYIGQ 276
                  |.:...|.|||:.:        |.|.||         .|.||..:..:..|        
Human   204 APPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESP-------- 260

  Fly   277 FFNRSSAPGMTHYSPPDPALLMQRQEANNLDQTIQPTQLQQPHSHH-QHFAYINSTTT 333
              :.||:...:..|||......:....:..|....|.....|..|| |.|:..|..|:
Human   261 --DSSSSSLSSGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTS 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd102CNP_651951.1 Forkhead 129..213 CDD:278670 43/85 (51%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51 9/33 (27%)
FH 78..166 CDD:214627 43/87 (49%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 10/14 (71%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 29/146 (20%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 26/112 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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