Protein Alignment fd102C and FOXG1

DIOPT Version :10

• Sequence 1: NP_651951.1
• Gene: fd102C / 43843
• FlyBaseID: FBgn0039937
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_005240.3
• Gene: FOXG1 / 2290
• HGNCID: 3811
• Length: 489
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 108/441 - (24%)
• Similarity: 153/441 - (34%)
• Gaps: 157/441 - (35%)

  Fly   129 KPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGRS 193
            ||..||..||.|||..|.:.:|.|:.||::|:.|:||:|....||:||||||||||.||:|..|.
Human   181 KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRH 245

  Fly   194 AN--GKGHYWAIHPANMEDF---RKGDFRRRKAQRKVR---------KHMGLSVDD--ASTDSPS 242
            .:  |||:||.:.|::.:.|   ..|..|||....:.:         ...||:..|  .|...|.
Human   246 YDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPM 310

  Fly   243 PPPLDLTTPPPPSSQSALQLSALGYPYHQHYIGQFFNRSSAPGMTHYSPPDPALLMQRQEANNLD 307
            .|.|.| ..|..||..:...:...||.|                   ..|..::|.|....||
Human   311 SPFLSL-HHPRASSTLSYNGTTSAYPSH-------------------PMPYSSVLTQNSLGNN-- 353

  Fly   308 QTIQPTQLQQPHSHHQHFAYINSTTTTTIANMFSQTRKRQFDVASLLAPDVQIVDIVSEDQESSV 372
                       ||                           |..|:.|                ||
Human   354 -----------HS---------------------------FSTANGL----------------SV 364

  Fly   373 TPTTSARTTTQTHHTVITKQTIHREVVLGLEKPVQDADIDADIDVEVNVDVVDDSIIPDTDSYTD 437
            ....:......|||  :|...:...|..||..|..
Human   365 DRLVNGEIPYATHH--LTAAALAASVPCGLSVPCS------------------------------ 397

  Fly   438 GEDRKKTRGTLKQIFSIEDNNSYLIDGRLSSFDADPDHDPDHDPEDLEQHNFSIASSAARSLGSS 502
                    ||    :|:...:..|:.|:.|.|.....|     |....|.:.|:::.||    ||
Human   398 --------GT----YSLNPCSVNLLAGQTSYFFPHVPH-----PSMTSQSSTSMSARAA----SS 441

  Fly   503 SSQHEESSSLEECPIQECIVAPQTALISSMATAKTSTLSVPISDAYLELNQ 553
            |:..:..|:|           |..:|..|:.:. |:.||..:||.:...||
Human   442 STSPQAPSTL-----------PCESLRPSLPSF-TTGLSGGLSDYFTHQNQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	FH_FOXQ2-like	129..223	CDD:410809	46/98 (47%)
FOXG1	NP_005240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..181		108/441 (24%)
		FH_FOXG	181..259	CDD:410795	40/77 (52%)
		COG5025	<184..>356	CDD:227358	65/231 (28%)
		Required for interaction with TLE6. /evidence=ECO:0000250|UniProtKB:Q60987	249..344		26/114 (23%)
		Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635	383..406		7/64 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..455		10/42 (24%)