DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and Foxc1

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	319	Identity:	96/319 - (30%)
Similarity:	132/319 - (41%)	Gaps:	77/319 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PQYGG----------TGGSGASAPWLHLSPYGH--HGSGSLPSVNRMAALSTISLFPQTQRIFQP 125
            |..||          ..|.|.:|....:|.|.|  |......|:.|.....|    ||.    ||
Mouse    17 PYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGSMARAYGPYT----PQP----QP 73

  Fly   126 EE-PKPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIK 189
            :: .||.:|||.||.|||.::.|.|:.|:.|||:|:|.:|::|....||:||||||||||:||:|
Mouse    74 KDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVK 138

  Fly   190 SGRSAN--GKGHYWAIHPANMEDFRKGDFRRRK-----------AQRKVRKHM--------GLSV 233
            ..|...  |||.||.:.|.:...|..|.|.||:           .:.|.|.|:        |...
Mouse   139 VPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQP 203

  Fly   234 DDA-------STDSPSPPPLDL--------TTPPPP---------SSQSALQLSALGYPYHQHYI 274
            ..|       |...|.|||:.:        |.|.||         .|.||..:..:..|
Mouse   204 APAPPEQAEGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESP------ 262

  Fly   275 GQFFNRSSAPGMTHYSPPDPALLMQRQEANNLDQTIQPTQLQQPHSHHQHFAYINSTTT 333
                 .||:..::..|.|..:|...|..:.:..:...|.|...|..|.|.|:..|..|:
Mouse   263 -----DSSSSSLSSGSSPPGSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	43/85 (51%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		9/33 (27%)
		FH	78..166	CDD:214627	43/87 (49%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		10/14 (71%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		32/155 (21%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		26/111 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820