DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd102C and Foxa1

DIOPT Version :9

Sequence 1:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_032285.2	Gene:	Foxa1 / 15375	MGIID:	1347472	Length:	468	Species:	Mus musculus

Alignment Length:	346	Identity:	99/346 - (28%)
Similarity:	143/346 - (41%)	Gaps:	54/346 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ADQDQGTSSRDSNVPKPSLPNIYPLGTTRTSQAQSTT--MTLEQYRLQLYNYALNIERLRCPQYG 76
            ||..:..||...:.....|.::..:.|..|....:|:  ||...:.:...|..|..........|
Mouse    20 ADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANTGLGAGLSPGAVAG 84

  Fly    77 GTGGS----------GASAPWLHLSPYGHHGSGSLP--SVNRMA--------ALSTISLFPQT-- 119
            ..|.|          |.:|....|||.|....|:.|  |:|.:.        .:|.::..|..
Mouse    85 MPGASAGAMNSMTAAGVTAMGTALSPGGMGSMGAQPATSMNGLGPYAAAMNPCMSPMAYAPSNLG 149

  Fly   120 ---------QRIFQPEEP--KPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGW 173
                     .:.|:...|  ||.:|||.||.|||..:....|.||:|||:|:|.:||:|.....|
Mouse   150 RSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRW 214

  Fly   174 RNSIRHNLSLNDCFIKSGRSAN--GKGHYWAIHPANMEDFRKGDFRRRKAQRKVRKHMGLSVDDA 236
            :|||||:||.||||:|..||.:  |||.||.:||.:...|..|.:.||:.:.|..|..|......
Mouse   215 QNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSG 279

  Fly   237 STDSPSPPP--LDLTTPPPPSSQSALQLSALGYPYHQHYIGQFFNRSSAPGMTHYSPPDPALLMQ 299
            ...|...|.  .|.:.|..||::|         |.|:...|:......||.      |.||...|
Mouse   280 GGGSKGGPESRKDPSGPGNPSAES---------PLHRGVHGKASQLEGAPA------PGPAASPQ 329

  Fly   300 RQEANNLDQTIQPTQLQQPHS 320
            ..:.:....|...::|:.|.|
Mouse   330 TLDHSGATATGGASELKSPAS 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	44/85 (52%)
Foxa1	NP_032285.2	Forkhead_N	17..169	CDD:369872	29/148 (20%)
		FH	170..258	CDD:214627	44/87 (51%)
		Essential for DNA binding	251..288		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..396		22/97 (23%)
		HNF_C	394..457	CDD:370449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910