DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyf and GIGYF1

DIOPT Version :9

Sequence 1:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster
Sequence 2:	NP_001362688.1	Gene:	GIGYF1 / 64599	HGNCID:	9126	Length:	1076	Species:	Homo sapiens

Alignment Length:	1690	Identity:	363/1690 - (21%)
Similarity:	544/1690 - (32%)	Gaps:	781/1690 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSMKFGPEWLRNMS-----AEPSGSPS--TYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRY 60
            :::.|||||||.:|     |.|..||:  .|.:.                           :|||
Human     4 ETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLA---------------------------DYRY 41

  Fly    61 GREEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPS 123
            ||||||:|:.:...:|:.|  ..|..:..::...||||.|.:||:....||..|| .|.|:....
Human    42 GREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNS-VAVLRLMGK 105

  Fly   124 GFGSASRGS--GRGGTVDRGRMRGKSAYHPIYQRP----SGLYDESLSVISKAERTWSDR----- 177
            |.|....|:  |||.|..|||.||.|.:   |||.    .|.:..|...|.::: :|.||
Human   106 GAGPPLAGTSRGRGSTRSRGRGRGDSCF---YQRSIEEGDGAFGRSPREIQRSQ-SWDDRGERRF 166

  Fly   178 --NGTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTR-----NEDGS---GDG 232
              :...|.|.......|:|           |||:::.:  :.||||..|     .|:||   |.|
Human   167 EKSARRDGARCGFEEGGAG-----------PRKEHARS--DSENWRSLREEQEEEEEGSWRLGAG 218

  Fly   233 PSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLS 297
            |...|..       |||....|..            ||..||:.       ...:|.      ..
Human   219 PRRDGDR-------WRSASPDGGP------------RSAGWREH-------GERRRK------FE 251

  Fly   298 TDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDAD-ENLPEWAIENPSKLGGSF 361
            .|..|:..|.|.....|.|..||.|...:          ..|.:.| :.||||.:::..:..|:|
Human   252 FDLRGDRGGCGEEEGRGGGGSSHLRRCRA----------PEGFEEDKDGLPEWCLDDEDEEMGTF 306

  Fly   362 DASGAFHGDTDLKPIKS-------SHNTLKTKSLDSYDDVKRPKSKDLSD--PDS-GNDITPETS 416
            ||||||      .|:|.       ....|..:.|:..::    .|:.|.:  |:: |.::||
Human   307 DASGAF------LPLKKGPKEPIPEEQELDFQGLEEEEE----PSEGLEEEGPEAGGKELTP--- 358

  Fly   417 LTKDTNTTAVQEEVESSLSPI-------------SSTTTKEV---------------------IH 447
                   ...|||..||.||:             ..|..||.                     ..
Human   359 -------LPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPP 416

  Fly   448 GDISD--RIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQA 510
            ||:.|  .:|.:..|.|||       ::|.|......:.||||
Human   417 GDLEDDEGLKHLQQEAEKL-------VASLQDSSLEEEQFTAA---------------------- 452

  Fly   511 PSTMPIQITPTITDVAPPSHAVVSFSDHETMQHHNMHHLPQFPMIPTPHIITPNLNELWFYRDPQ 575
                                          ||...:.|......:|..|    .....|||:|||
Human   453 ------------------------------MQTQGLRHSAAATALPLSH----GAARKWFYKDPQ 483

  Fly   576 ANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELEN 640
            ..:||||:..||.||::||||:.:|.|:|..|..|:||||:||. .|.:||
Human   484 GEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKM-WGRVPF-------------- 533

  Fly   641 IPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGN 705
                   ||          .|||.|:..::.:::|::|:            |...||:.
Human   534 -------AP----------GPSPPPLLGNMDQERLKKQQ------------ELAAAALY------ 563

  Fly   706 SIGNTSHLLTMRFQMLQDQYIQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLIS 770
                              |.:|||::
Human   564 ------------------QQLQHQQF--------------------------------------- 571

  Fly   771 LNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQ 835
                      |..|:.|||.:..:              .::.::|
Human   572 ----------LQLVSSRQLPQCAL--------------REKAALG-------------------- 592

  Fly   836 QEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATE 900
                                ||..|                      .|...|||...||
Human   593 --------------------DLTPP----------------------PPPPPQQQQQQLT----- 610

  Fly   901 NLPGVDFLTETQLLE-----RQNLMIPIWLP--------PNNNKQQETDQQWAEMSNADASLWET 952
                 .||.:.|.|:     .|||     ||        |::.:..:.....:..|..:||||:
Human   611 -----AFLQQLQALKPPRGGDQNL-----LPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWD- 664

  Fly   953 ANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQ 1017
                        :.|..|::.                         ..||:|..
Human   665 ------------IPINSSTQG-------------------------PILEQLQL----------- 681

  Fly  1018 KIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQR 1082
                                 ||:.::..:..|..                  |||: ||:||:.
Human   682 ---------------------QHKFQERREVELRA------------------KREE-EERKRRE 706

  Fly  1083 EERKRQQLEDDKRRALNESEEQTRQIQEEKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQ 1147
            |:|::||.|:.|||            |||:|..::...::::.||
Human   707 EKRRQQQQEEQKRR------------QEEEELFRRKHVRQQELLL-------------------- 739

  Fly  1148 SKKNDDAKTAEPQVSSRLPSTSVAP---WSFQLQNSMRSAPGLAEIQKAERRERRADQQRHQELL 1209
                   |..:.|.:..:|....:|   |:           |||
Human   740 -------KLLQQQQAVPVPPAPSSPPPLWA-----------GLA--------------------- 765

  Fly  1210 DKQLRANAAAAAEANDALLKWQSTPASAPVMSLAEIQAEEARRLANDLVDRQ-RRRELEHHQ--- 1270
             ||                       ...:.:|.|:|.|..|:|......|: .|.:..:|:
Human   766 -KQ-----------------------GLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQL 806

  Fly  1271 ----QAPLSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKTSSGTGLW-DEPNPLGSNGSGTSGT 1330
                .|||:..|   |....:||..:|:...          |||.||| |.|...||
Human   807 GGLGTAPLNQWV---SEAGPLWGGPDKSGGG----------SSGLGLWEDTPKSGGS-------- 850

  Fly  1331 SSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQK 1395
                    |..||                      .|:.|::.|:||: ..|:.:|   ||.::|
Human   851 --------LVRGL----------------------GLKNSRSSPSLSD-SYSHLSG---RPIRKK 881

  Fly  1396 LAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLDNMSA--KVDVP 1458
                        .||:::..||            :..:...::.||.||.:.|..:||  .:|||
Human   882 ------------TEEEEKLLKL------------LQGIPRPQDGFTQWCEQMLHTLSATGSLDVP 922

  Fly  1459 TFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYK----------------SLQRA 1507
            ..||.|:::|:||:|.||:|..|||..::.:|||||||||:|.|                |||.|
Human   923 MAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTA 987

  Fly  1508 QKAHNDDMCKPAPAITPSANDYADSKNKQKKIKKNKMTKMDARILG------FSVTAAEGRINVG 1566
            .:|::.....|...          ||.|::.:    |...|..|||      ...:.|:||.:.|
Human   988 FQANHSTKLGPGEG----------SKAKRRAL----MLHSDPSILGELGWGRSGTSLAQGRRSPG 1038

Fly 1567 1566
Human 1039 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	29/54 (54%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	23/113 (20%)
GIGYF1	NP_001362688.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..422		95/395 (24%)
		GYF	476..529	CDD:238027	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..640		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..724		17/40 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	825..879		25/105 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145444
Domainoid	1	1.000	154	1.000	Domainoid score	I4260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3346
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm40590
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R738
SonicParanoid	1	1.000	-	-		X2990
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.020