DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyf and Gigyf1

DIOPT Version :9

Sequence 1:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster
Sequence 2:	XP_006504670.1	Gene:	Gigyf1 / 57330	MGIID:	1888677	Length:	1075	Species:	Mus musculus

Alignment Length:	1628	Identity:	349/1628 - (21%)
Similarity:	522/1628 - (32%)	Gaps:	750/1628 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSMKFGPEWLRNMS-----AEPSGSPS--TYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRY 60
            :::.|||||||.:|     |.|..||:  .|.:.                           :|||
Mouse     4 ETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLA---------------------------DYRY 41

  Fly    61 GREEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPS 123
            ||||||:|:.:...:|:.|  ..|..:..|:...||||.|.:||:....||..|| .|.|:....
Mouse    42 GREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEEEQRNFSLSVNS-VAVLRLMGK 105

  Fly   124 GFG----SASRGSGRGGTVDRGRMRGKSAYHPIYQRP----SGLYDESLSVISKAERTWSDRN-- 178
            |.|    :.||  |||.|..|||.||.|.:   |||.    .|.:..:...|.::: :|.||.
Mouse   106 GAGPPLPATSR--GRGSTRSRGRGRGDSCF---YQRSIEEGDGAFGRNPREIQRSQ-SWDDRGER 164

  Fly   179 -----GTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTRNE---DGS---GDG 232
                 ...|...:.....|:|           |||:::.:  :.||||..|.|   |||   |.|
Mouse   165 RFEKPARRDGVRSGFEEGGAG-----------PRKEHARS--DSENWRSLREEQEDDGSWRLGAG 216

  Fly   233 PSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLS 297
            |...|..       |||            |:.....||..||:.       ...:|.      ..
Mouse   217 PRRDGDR-------WRS------------TSPDGGPRSAGWREH-------GERRRK------FD 249

  Fly   298 TDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADEN----LPEWAIENPSKLG 358
            .|..|...|.|.......|..||.|             ...|:|..|:    ||||.:|:..:..
Mouse   250 FDLRGERGGCGEEDGRVGGGNSHLR-------------RCRGLDGFEDDKDGLPEWCLEDEDEEM 301

  Fly   359 GSFDASGAFHGDTDLK----------------PIKSSHNTLKT----------------KSLDSY 391
            |:|||||||   ..||                |....|:.|.|                :.|:..
Mouse   302 GTFDASGAF---LPLKVLISGASGVVAAAPWLPSHCVHSALPTQKGPKEAIPEEQELDFRGLEEE 363

  Fly   392 DDVKRPKSKDLSD--PDS-GNDIT----PETS-------------LTKDTNTTAVQEEVES---- 432
            ::.:...|:.:.:  |:: |.:.|    ||.|             .|.:....||::|:..
Mouse   364 EEEEEEPSEGVDEERPEAGGKEATPLPPPENSSSPSSLPALGPLWTTNEEGGEAVEKELPPAEGD 428

  Fly   433 -----SLSP-ISSTTTKEVIHGDISDR--IKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAAL 489
                 |||| |||.....   ||:.|.  :|.:..|.|||       ::|.|......:.||||
Mouse   429 ELRGLSLSPRISSPPGPP---GDLEDEEGLKHLQQEAEKL-------VASLQDSSLEEEQFTAA- 482

  Fly   490 PRMADIEINVKPSVTAVHRQAPSTMPIQITPTITDVAPPSHAVVSFSDHETMQHHNMHHLPQFPM 554
                                                               ||...:.|......
Mouse   483 ---------------------------------------------------MQTQGLRHSTAATA 496

  Fly   555 IPTPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKF 619
            :|..|    .....|||:|||..:||||:..||.||::||||:.:|.|:|..|..|:||||:||.
Mouse   497 LPLSH----GAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKM 557

  Fly   620 CHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQQQRDEQLK 684
             .|.:||                     ||          .|||.|:..::.:::|::|:
Mouse   558 -WGRVPF---------------------AP----------GPSPPPLLGNMDQERLKKQQ----- 585

  Fly   685 ANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQEY-QILAELSKNECFQRLSA 748
                   |...||:.                        |.:|||.: |::......:|
Mouse   586 -------ELAAAALY------------------------QQLQHQHFLQLVGSRQLPQC------ 613

  Fly   749 VEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRS 813
                |.:|.|.                 ::..|.|...:||
Mouse   614 ----TTLREKA-----------------AMGDLTPPQQQQL------------------------ 633

  Fly   814 VGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLRM 878
                          ...:||.|....|         :||                    :.||.
Mouse   634 --------------TTFLQQLQALKTP---------RGG--------------------DQNLL- 654

  Fly   879 LLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWLPPNNNKQQETDQQWAEMS 943
                         |.::.|.:....|                 |:|         :.....:..|
Mouse   655 -------------PTMSRSLSVPDSG-----------------PLW---------DLHTSASSQS 680

  Fly   944 NADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQSP 1008
            ..:||||:             :.|..|::.                         ..||:|..
Mouse   681 GGEASLWD-------------IPINSSTQG-------------------------PILEQLQL-- 705

  Fly  1009 QNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKRE 1073
                                          ||:.::                          :||
Mouse   706 ------------------------------QHKFQE--------------------------RRE 714

  Fly  1074 QTEEKKRQREERKRQQLEDDKRRALNESEEQTRQIQEEKERQQQIQAQRRKALLGNVHSLSVQNG 1138
            .....||:.|||||:   ::|||      :|.:|.:|:|.||::.:..|||
Mouse   715 VELRAKREEEERKRR---EEKRR------QQQQQQEEQKRRQEEEELFRRK-------------- 756

  Fly  1139 MSGTLASAQSKKNDDAKTAEPQVSSRLPSTSVAPWSFQLQNSMRSAPGLAEIQKAERRERRADQQ 1203
                                                                           |.
Mouse   757 ---------------------------------------------------------------QV 758

  Fly  1204 RHQELLDKQLRANAAAAAEANDALLKWQSTPASAP------------VMSLAEIQAEEARRLAND 1256
            |.||||.|.|:...|.......|       |:|.|            :.:|.|:|.|..|:|...
Mouse   759 RQQELLLKLLQQQQATNVPVPPA-------PSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQ 816

  Fly  1257 LVDRQ-RRRELEHHQ-------QAPLSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKTSSGTGL 1313
            ...|: .|.:..:|:       .|||:..|   |....:||..:|:..||         ....||
Mouse   817 AAPREPLRAQAPNHRVQLGGLGSAPLNQWV---SEAGPLWGGPDKSGGSS---------GGNLGL 869

  Fly  1314 WDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQTLPALSN 1378
            |::                                 ||    ||....|....|:.|::.|:||:
Mouse   870 WED---------------------------------TL----KSGGSLARSLGLKSSRSSPSLSD 897

  Fly  1379 PEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFTSW 1443
             ..|:.:|   ||.::|            .||:::..||            :..:...::.||.|
Mouse   898 -SYSHLSG---RPVRKK------------TEEEEKLLKL------------LQGIPRPQDGFTQW 934

  Fly  1444 CIKSLDNMS--AKVDVPTFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYKSLQR 1506
            |.:.|..:|  ..:|||..||.|:::|:||:|.||:|..|||..::.:|||||||||:|.|:.|:
Mouse   935 CEQMLHTLSTAGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQ 999

  Fly  1507 AQK 1509
            .|:
Mouse  1000 RQQ 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	29/54 (54%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	20/113 (18%)
Gigyf1	XP_006504670.1	PRK12678	113..>265	CDD:237171	52/202 (26%)
Gigyf1	XP_006504670.1	GYF	506..559	CDD:238027	29/53 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835511
Domainoid	1	1.000	157	1.000	Domainoid score	I4151
eggNOG	1	0.900	-	-		E1_KOG1862
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3426
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm42666
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R738
SonicParanoid	1	1.000	-	-		X2990
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.880