DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyf and gigyf2

DIOPT Version :9

Sequence 1:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster
Sequence 2:	NP_001025332.2	Gene:	gigyf2 / 561830	ZFINID:	ZDB-GENE-050706-185	Length:	1329	Species:	Danio rerio

Alignment Length:	1778	Identity:	411/1778 - (23%)
Similarity:	648/1778 - (36%)	Gaps:	661/1778 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFP--------EY 58
            |.::.|||||||.::                     ||  :|::..||..  |.|        :|
Zfish     4 TQTLNFGPEWLRALA---------------------GG--VGSSIVASPP--LSPALPKYKLADY 43

  Fly    59 RYGREEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRS 121
            ||||||||:|:.::.::|..|  ..|..:..|:...||||.|.:||:....|:..|| .|.|:.:
Zfish    44 RYGREEMLALYVKDNMIPVDLHDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNS-AAVLRLT 107

  Fly   122 PSGFGSASRGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVIS----------KAERTWSD 176
            ..|.|:.: |:.||.:..|||.||         |..|.|..|...:.          ...::|.:
Zfish   108 GRGGGTVA-GAPRGRSSSRGRGRG---------RGDGFYQRSFDDVEGGFGRGGREMHRSQSWEE 162

  Fly   177 RNGTGDSAATTTSTSGSGALDWNGTPSSSP----RKDYSNN---------HRNLENWRRTRNEDG 228
            |   ||     ......|..|.:|.|:..|    |.:|.:.         |...:|||.||:|
Zfish   163 R---GD-----RRFEKPGRKDPDGAPAHFPLNHIRANYEDPAAVNARKFIHAECDNWRTTRDE-- 217

  Fly   229 SGDGPSSSGSMSG-PDIAGWRSGVVGGSTNAGFGTNSHRW-------GRSTSWRDEDPSVDNAAS 285
                      ::| .|..|||.        ||....:.||       .||..|| |.|.
Zfish   218 ----------LNGEEDDNGWRL--------AGARRENERWCPPSPDGPRSAGWR-EHPD------ 257

  Fly   286 LQRSISTVATLSTDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPEWA 350
             ||                :..|.|..|..| ...||..|           .:..:..::||||.
Zfish   258 -QR----------------RRFGFGDEERSG-YRRPRSGS-----------GSAEEERDSLPEWC 293

  Fly   351 IENPSKLGGSFDASGAFHGDTDLKPIKSSHNTLKTKSLDSYDDVKRPKSKDLSDPDSGNDITP-- 413
            :|:..:..|:||:||||             .:||.::|:     |.||...|.:.:.  |..|
Zfish   294 LEDAEEETGTFDSSGAF-------------LSLKVRALE-----KAPKEPILEEAEL--DFRPLE 338

  Fly   414 -----------ETSLTKDTNTTAVQEE------------------VESSLSPISSTTTKEV--IH 447
                       ||..||||:|....|.                  ..:.::|..:||...:  :|
Zfish   339 ENDEYAEKDDSETEQTKDTDTNTRHESDRNEENCKSEEPSPVAVPFSAVVTPPKATTPAPIQPVH 403

  Fly   448 GDISD---------RIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMA----DIEINV 499
            .:.::         .:.|:..|:.|..:   |...||....      ..::|.:|    |:.:..
Zfish   404 LEKAEDKERPSERTTLPEIRHELSKAPL---HTALSNSIVE------AISIPHVANKLPDLPVPA 459

  Fly   500 KPSVTAVHRQAPST-------MPIQITP-------TITDVAPPSHAVVSFSDHETMQHHNMHHLP 550
             |||..|....|.:       ||:.:.|       ::..::.||.......:.|.::|.......
Zfish   460 -PSVLPVKSVPPQSQQVKPIEMPVSVPPALLRSTGSVGPISRPSALPSDLDEDEGLKHFEQEAEK 523

  Fly   551 QFPMI---------------PTPHIITPNLNEL---WFYRDPQANVQGPFSAVEMTEWYRAGYFN 597
            ....:               |.|..: |..||.   |||:|||..:||||:..||:||::||||.
Zfish   524 MVAYLQDGGVDDERLASKIGPKPSAL-PITNEAAFKWFYKDPQGEIQGPFNNQEMSEWFQAGYFT 587

  Fly   598 ENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPS 662
            ..|.|:|..|..|:||||:||. .|.:|||                   |.|
Zfish   588 MTLQVKRGCDEMFQPLGEMIKL-WGRVPFT-------------------PGP------------- 619

  Fly   663 PIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQ 727
            .:|..|...:|: :.:|.:::.|                           |...:.|.:|.||:.
Zfish   620 TLPPILGDADQE-RMKRQQEINA---------------------------LNMYQLQQMQYQYLL 656

  Fly   728 HQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRA 792
            .|:|                |::|:.:                     ||.....|...:||
Zfish   657 RQQY----------------ALQQKVL---------------------NSAPPPPPPPQQQL--- 681

  Fly   793 VVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQ--QSQQEVGPLVSSVDCIMQGGTAA 855
                                         |.:|:..:.|:  :.||.:.|.|:....:...|:..
Zfish   682 -----------------------------NLLLHQALKIRTPEPQQSLLPPVTRSMSVPDSGSVW 717

  Fly   856 DLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQ-PPALTNSATENLPGVDFLTETQLLERQNL 919
            ::..|                         |||.. .|.:..:|.....|..
Zfish   718 EMQNP-------------------------STQASCSPNMQPAAPSTWEGSS------------- 744

  Fly   920 MIPIWLPPNNNKQQETDQQWAEMSNADASLWE----TANLNEERNEDQQLLIQKSSEACFADTEK 980
               :|..|.:|..|.:..:..::..|.|...|    .|.|..:|.|:::   ::..||..|..|:
Zfish   745 ---VWDLPLDNMPQASSIEQLQLEKAKALKLEMERREAELRAKREEEER---KRLEEALRARQEE 803

  Fly   981 DVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQA 1045
            :.|                .|||                     .::.:...||....|.:.::|
Zfish   804 ERK----------------RLEE---------------------EELARRKQEEALKRQREQEEA 831

  Fly  1046 NKQNLNTKQNAAQ-SALKPINNENDRKREQTEEKKRQREE----------RKRQQLEDDKRR--- 1096
            .::....::..|| .||:.:   .:|:||  ||::|||||          ||:::||..:||
Zfish   832 QRRKKEEEERLAQEEALRRL---EERRRE--EEERRQREEFLRKQQEEERRKQEELEAQRRREEE 891

  Fly  1097 -------------ALNESEEQTRQIQEEKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQS 1148
                         .|.:.:|:.::.::|.:|||::|.||::              ....|...|.
Zfish   892 KRLEEEAAAAAAALLRQQQEEQKKREQEAQRQQELQRQRQQ--------------QQEALRRLQQ 942

  Fly  1149 KKNDDAKTAEPQVSSRLPSTSVAPWSFQ--LQNSM---RSAPGLAEIQKAE---RRERRADQQRH 1205
            ::..     :.....:|||:|  .|..|  ..||:   ::|..||||||.|   .|:.|.:|:|.
Zfish   943 QQQQ-----QQLAQMKLPSSS--KWGQQSTTANSLSQSQNALSLAEIQKLEEERERQTREEQRRQ 1000

  Fly  1206 QELLDKQLRANAAAAAEANDALLKWQSTPASAPV--MSLAEIQAEEARRLANDLVDRQRRRELEH 1268
            |:.|.:      ....:....|..|.|. |..|:  .||.|||.|||:::.    .|:.:::.:.
Zfish  1001 QQELQR------VQQQQPQTKLPGWGSV-AKQPMATKSLLEIQREEAQQMK----QRKDQQQQQQ 1054

  Fly  1269 HQQAP------------------LSSAVLVTSATSNIWGNANKAWSSSAAQSLSL---KTSSGTG 1312
            .||.|                  .:.|.:.||    :||:.|.. ||:.....|:   ..:|..|
Zfish  1055 QQQQPPPQPQPQQHSTNTQQNRTQNRAAINTS----VWGSVNNV-SSNWMMDSSVWGDTQNSNIG 1114

  Fly  1313 LWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQTLPALS 1377
            .|||               :|..|                         |.|:..|||.|
Zfish  1115 FWDE---------------AVKEA-------------------------APPQTTRKSHT----- 1134

  Fly  1378 NPE-KSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFT 1441
             |: |.|.|          |:.:.|..|:..:||:::..||            ....|:.::.|.
Zfish  1135 -PKNKGNAN----------LSNSSSGKASKKVEEEEKLLKL------------FQGANKNQDGFM 1176

  Fly  1442 SWCIKSLD--NMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYKSL 1504
            .||.::|.  |.:..:|||||.:||:::::||||.||||.||||...:.||||||||||:|....
Zfish  1177 QWCEQTLHTLNTANNLDVPTFASFLKEVDSPYEVHDYVRAYLGDTPQAKDFAKQFLERRAKQNDN 1241

  Fly  1505 QRAQKAHNDDMCKPAPAI-----TPSANDYADSKNKQ---------------KKIKKNKMTKMDA 1549
            |  ||.......|...::     .|.:......:.:|               ||.||.||.:.|.
Zfish  1242 Q--QKPQQGQQQKQQESVWGIREVPQSVLLQQQQQQQLQQQQQQRFETVTSGKKKKKQKMVRADP 1304

  Fly  1550 RILGFSVTAAEGRINVGIRDYVE 1572
            .:|||||.|:..|:|:|..:.||
Zfish  1305 SLLGFSVNASSERLNMGEIETVE 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	31/57 (54%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	29/140 (21%)
gigyf2	NP_001025332.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..184		22/92 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..419		50/238 (21%)
		GYF	557..612	CDD:214666	29/55 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..740		6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..1081		85/376 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1122..1155		14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1236..1256		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1279..1302		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578717
Domainoid	1	1.000	148	1.000	Domainoid score	I4430
eggNOG	1	0.900	-	-		E1_KOG1862
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2780
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm26306
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R738
SonicParanoid	1	1.000	-	-		X2990
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.880