Protein Alignment Gyf and Gigyf1

DIOPT Version :10

• Sequence 1: NP_001162827.1
• Gene: Gyf / 43842
• FlyBaseID: FBgn0039936
• Length: 1574
• Species: Drosophila melanogaster
• Sequence 2: NP_001100603.1
• Gene: Gigyf1 / 304378
• RGDID: 1309933
• Length: 1042
• Species: Rattus norvegicus
• Alignment Length: 1674
• Identity: 347/1674 - (20%)
• Similarity: 537/1674 - (32%)
• Gaps: 741/1674 - (44%)

  Fly     3 DSMKFGPEWLRNMS-----AEPSGSPS--TYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRY 60
            :::.|||||||.:|     |.|..||:  .|.:.                           :|||
  Rat     4 ETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLA---------------------------DYRY 41

  Fly    61 GREEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPS 123
            ||||||:|:.:...:|:.|  ..|..:..|:...||||.|.:|::....||..|| .|.|:....
  Rat    42 GREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEDEQRNFSLSVNS-VAVLRLMGK 105

  Fly   124 GFGS--ASRGSGRGGTVDRGRMRGKSAYHPIYQRP----SGLYDESLSVISKAERTWSDR----- 177
            |.|.  |:...|||.|..|||.||.|.:   |||.    .|.:..:...|.::: :|.||
  Rat   106 GAGPPLAATSRGRGSTRSRGRGRGDSCF---YQRSIEEGDGAFGRNPREIQRSQ-SWDDRGERRF 166

  Fly   178 --NGTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTRNE---DGS---GDGPS 234
              :...|...:.....|:|           |||:::.:  :.||||..|.|   |.|   |.||.
  Rat   167 EKSARRDGVRSGFEEGGAG-----------PRKEHARS--DSENWRSLREEQEDDSSWRLGAGPR 218

  Fly   235 SSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLSTD 299
            ..|..       |||            |:.....||..||:.       ...:|.      ...|
  Rat   219 RDGDR-------WRS------------TSPDGGPRSAGWREH-------GERRRK------FDFD 251

  Fly   300 RTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADEN----LPEWAIENPSKLGGS 360
            ..|...|.|.......|..||.|             ...|:|..|:    ||||.:::..:..|:
  Rat   252 LRGERGGCGEEDGRVGGGNSHLR-------------RCRGLDGFEDDKDGLPEWCLDDEDEEMGT 303

  Fly   361 FDASGAFHGDTDLKPIKS-------SHNTLKTKSLDSYDDVKRPK-SKDLSDPDS-GNDITPETS 416
            |||||||      .|:|.       ....|..:.|:  ::.:.|. ..|...|:: |.::||...
  Rat   304 FDASGAF------LPLKKGPKEPIPEEQELDFQGLE--EEEEEPSDGVDEEGPEAGGKEVTPLPP 360

  Fly   417 LTKDTNTTAVQ------------EEVESSLSP--------------ISSTTTKEVIHGDISDRIK 455
            ..|.::.:::.            |.||..|.|              |||.........:..:.:|
  Rat   361 SEKSSSPSSLPALGPLWTANEDGEAVEKELPPAEGDEMRGLPLSPRISSPPAGPPADLEDEEGLK 425

  Fly   456 EVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQAPSTMPIQITP 520
            .:..|.|||       ::|.|......:.||||
  Rat   426 HLQQEAEKL-------VASLQDSSLEEEQFTAA-------------------------------- 451

  Fly   521 TITDVAPPSHAVVSFSDHETMQHHNMHHLPQFPMIPTPHIITPNLNELWFYRDPQANVQGPFSAV 585
                                ||...:.|......:|..|    .....|||:|||..:||||:..
  Rat   452 --------------------MQTQGLRHSTAATALPLSH----GAARKWFYKDPQGEIQGPFTTQ 492

  Fly   586 EMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPL 650
            ||.||::||||:.:|.|:|..|..|:||||:||. .|.:||                     ||
  Rat   493 EMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKM-WGRVPF---------------------AP- 534

  Fly   651 TASLSITPHKPSPIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLT 715
                     .|||.|:..::.:::|::|:            |...||:.
  Rat   535 ---------GPSPPPLLGNMDQERLKKQQ------------ELAAAALY---------------- 562

  Fly   716 MRFQMLQDQYIQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSV 780
                    |.:|||.:                           :||:|
  Rat   563 --------QQLQHQHF---------------------------LQLVG----------------- 575

  Fly   781 LNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSV 845
                 .|||.:.             |...::.::|:|              ...||::...:..:
  Rat   576 -----SRQLPQC-------------ATLREKAAMGDL--------------TPPQQQLTTFLQQL 608

  Fly   846 DCIMQGGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTE 910
            ..:             :.||.     .:.||.              |.::.|.:....|
  Rat   609 QAL-------------KTPRG-----GDQNLL--------------PTMSRSLSVPDSG------ 635

  Fly   911 TQLLERQNLMIPIWLPPNNNKQQETDQQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACF 975
                       |:|         :.....:..|..:||||:             :.|..|::.
  Rat   636 -----------PLW---------DLHTSASSQSGGEASLWD-------------IPINSSTQG-- 665

  Fly   976 ADTEKDVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQH 1040
                                   ..||:|..                                ||
  Rat   666 -----------------------PILEQLQL--------------------------------QH 675

  Fly  1041 QVKQANKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQREERKRQQLEDDKRRALNESEEQT 1105
            :.::..:..|..|:.                    ||::::|||::|||
  Rat   676 KFQERREVELRVKRE--------------------EEERKRREEKRRQQ---------------- 704

  Fly  1106 RQIQEEKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPSTSV 1170
            :|.:|:|.||::.:..|||
  Rat   705 QQQEEQKRRQEEEELFRRK---------------------------------------------- 723

  Fly  1171 APWSFQLQNSMRSAPGLAEIQKAERRERRADQQRHQELLDKQLRANAAAAAEANDALLKWQSTPA 1235
                                           |.|.||||.|.|:...|.......|       |:
  Rat   724 -------------------------------QVRQQELLLKLLQQQQATNVPVPPA-------PS 750

  Fly  1236 SAP------------VMSLAEIQAEEARRLANDLVDRQ--RRRELEHHQQ------APLSSAVLV 1280
            |.|            :.:|.|:|.|..|:|......|:  |.:...|..|      |||:..|
  Rat   751 SPPPLWAGLAKQGLSMKTLLELQMESERQLHKQPAPREPLRAQAPNHRVQLGGLGTAPLNQWV-- 813

  Fly  1281 TSATSNIWGNANKAWSSSAAQSLSLKTSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNS 1345
             |....:||..:|:..||         |...|||::
  Rat   814 -SEAGPLWGGPDKSGGSS---------SGNLGLWED----------------------------- 839

  Fly  1346 ANKSTLQAQNKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEE 1410
                ||    ||....|....|:.|::.|:||: ..|:.:|   ||.::|            .||
  Rat   840 ----TL----KSGGSLARSLGLKNSRSSPSLSD-SYSHLSG---RPVRKK------------TEE 880

  Fly  1411 KDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLDNMS--AKVDVPTFVAFLQDLEAPYEV 1473
            :::..||            :..:...::.||.||.:.|..:|  :.:|||..||.|:::|:||:|
  Rat   881 EEKLLKL------------LQGIPRPQDGFTQWCEQMLHTLSTTSSLDVPMAVAILKEVESPYDV 933

  Fly  1474 KDYVRIYLGDGKDSLDFAKQFLERRSKYKSLQRAQKAHNDDMCKPAPAITPSANDYADSKNKQKK 1538
            .||:|..|||..::.:|||||||||:|.|:.|:.|:.......:.    ......:..|.:.|..
  Rat   934 HDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQ----QQQQEAWLSSSSLQTA 994

  Fly  1539 IKKNKMTKM-----------------DARILGFSVTAAEGRINVGIRDY 1570
            .:.|..||:                 |..|||:|:....|.|. .:.||
  Rat   995 FQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIE-SVDDY 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	569..613	CDD:460496	23/43 (53%)
		Mplasa_alph_rch	<931..>1113	CDD:275316	24/181 (13%)
Gigyf1	NP_001100603.1	PRK12678	112..>265	CDD:237171	50/201 (25%)
		GYF	475..528	CDD:238027	29/53 (55%)