|
Fly 2 TDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGREEML 66
|.::.|||||||.:|: ||.......:.:..:....:|||||||||
Human 5 TQTLNFGPEWLRALSS--------------------GGSITSPPLSPALPKYKLADYRYGREEML 49
Fly 67 SLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPSGFGSAS 129
:||.::..:|..| ..|..:..|:...||||.|.:||:....|:..|| .|.|:.:..|.|...
Human 50 ALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNS-AAVLRLTGRGGGGTV 113
Fly 130 RGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKA-------ERTWSDRNGTGDSAATT 187
.|:.||.:..|||.||:... ..|||. :||...|..:. .::|.:| ||.....
Human 114 VGAPRGRSSSRGRGRGRGEC-GFYQRS---FDEVEGVFGRGGGREMHRSQSWEER---GDRRFEK 171
Fly 188 TSTSGSGALDW-----------------------NGTPSSSPRKDYSNNHRNL----ENWRRTRN 225
......|..:. .|.|:|..|| |..: ||||..|.
Human 172 PGRKDVGKKNGYYCMYSPVLLLGQPLCQGRPNFEEGGPTSVGRK-----HEFIRSESENWRIFRE 231
Fly 226 EDGSGDGPSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRW-------GRSTSWRDEDPSVDNA 283
|....| :..||| :.||...| .|| .||..||:.
Human 232 EQNGED-----------EDGGWR---LAGSRRDG-----ERWRPHSPDGPRSAGWREH------- 270
Fly 284 ASLQRSISTVATLSTDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPE 348
...:|..........|..|..: ...|.|||...| ::|||
Human 271 MERRRRFEFDFRDRDDERGYRR-----VRSGSGSIDDDR---------------------DSLPE 309
Fly 349 WAIENPSKLGGSFDASGAF-------------HGDTDLKPI---------KSSHNTLKTKSLDSY 391
|.:|:..:..|:||:|||| ..:.|.:|: :.|||
Human 310 WCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN---------- 364
Fly 392 DDVKRPKSKDLSDPDS------GNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKEVIHGDI 450
::.|.|...:..:.:. .::.||:|| .||..| |..
Human 365 EEAKEPDKTNKKEGEKTDRVGVASEETPQTS--------------SSSARP-----------GTP 404
Fly 451 SDRIKEVADEVEKLIMDDDHKISSNQSQHQN---HDGFTAALP-----RMADIE--INVKPSVTA 505
||...:.|.:.|: .|:.|....:...:. .:...|.:| .:||:: ::..||.||
Human 405 SDHQSQEASQFER---KDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTA 466
Fly 506 ---------VHRQAPSTMPIQITPTITDVAPPSHAVVSF--SDHETMQHHN-------------- 545
|...:|:..|:: ||. |..|....||. .|.|.::|..
Human 467 SPLLILPPPVPNPSPTLRPVE-TPV---VGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSA 527
Fly 546 ----------MHHLPQFPMIPTPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAGYFNENL 600
..|..:...||..| ...:.|:|:|||..:||||:..||.||::||||..:|
Human 528 LDDERLASKLQEHRAKGVSIPLMH----EAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSL 588
Fly 601 FVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIP 665
.|:|..|..|:|||:::|. .|.:|| || |..|.|....|.
Human 589 LVKRACDESFQPLGDIMKM-WGRVPF-------SP--------GPAPPPHMGELD---------- 627
Fly 666 IALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQE 730
:::|.:|:: ||..:|| ||.:
Human 628 ------QERLTRQQE---------------------------------LTALYQM------QHLQ 647
Fly 731 YQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVE 795
|| ::|| :|.|..|:
Human 648 YQ---------------------------------QFLI-----------------QQQYAQVL- 661
Fly 796 HAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKP 860
..||....:::||:.:..||.... .:.::.|.|.:.|.|:....:...|:..:|
Human 662 ---AQQQKAALSSQQQQQLALLLQQFQ-----TLKMRISDQNIIPSVTRSVSVPDTGSIWEL--- 715
Fly 861 NEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWL 925
|||:: ||......:..:|| :|..|....||:.. .|
Human 716 ----------------------QPTAS--QPTVWEGGSVWDLP-LDTTTPGPALEQLQ-----QL 750
Fly 926 PPNNNKQQETDQQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQV 990
......:.|.:::.||| .|...||..:.|:.|.::..|......|::.|
Human 751 EKAKAAKLEQERREAEM---------RAKREEEERKRQEELRRQQEEILRRQQEEERK------- 799
Fly 991 QSGNVVNHTALEELDQSPQN--LKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTK 1053
....|||.:..|. |:....|:|... :|...||....:..:::..::....:
Human 800 -------RREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLEERRREEE 852
Fly 1054 QNAAQSALKPINNENDRKREQTEEKKRQREERKRQQLEDDKRRALNESEEQTR---QIQEEKE-- 1113
:...|..|.....|...|..:.||:.::|.|..|.::|::..|..:|.||:.| ::|.:||
Human 853 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 917
Fly 1114 --RQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPSTSVAPWSFQ 1176
||||.:|.|| |...|.: :.....:|||:|. |..|
Human 918 RQRQQQQEALRR-------------------LQQQQQQ--------QQLAQMKLPSSST--WGQQ 953
Fly 1177 LQNS---MRSAPGLAEIQK-AERRER--RADQQRHQELLDKQLRANAAAAAEANDALLKWQS-TP 1234
...: .::...|||||| .|.||| |.:|:|.|..|.|.|:.. ..:....|..|.: :.
Human 954 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKLSGWGNVSK 1015
Fly 1235 ASAPVMSLAEIQAEEARRLANDLVDRQRRRELEHHQQAPL---SSAVLVTSATSNIWGNAN---- 1292
.|....||.|||.||||:: .:|::::.:|.|.... :.:.|.||..:::||:.|
Human 1016 PSGTTKSLLEIQQEEARQM-----QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1075
Fly 1293 KAWSSSAAQSL---SLKTSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQ 1354
..|:|....|: :...:|..|.||: |....|..||.||
Human 1076 NQWASDLVSSIWSNADTKNSNMGFWDD-------------------AVKEVGPRNSTNK------ 1115
Fly 1355 NKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNA 1419
||::| :|.|| ..:|| :.|| .:||:::..||
Human 1116 NKNNA------SLSKS---VGVSN--RQNK----------------------KVEEEEKLLKL-- 1145
Fly 1420 KSQQSSTDQAISKVNEYENEFTSWCIKSLD--NMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLG 1482
...||:.::.||.||.:.|. |.:..:||||||:||:::|:||||.||:|.|||
Human 1146 ----------FQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLG 1200
Fly 1483 DGKDSLDFAKQFLERRSKYKSLQRAQKAHNDDMCKPAPAITP-------------------SAND 1528
|..::.:|||||||||:|.|:.|:.|:.......:..|...| |...
Human 1201 DTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQ 1265
Fly 1529 YADSKNKQ---------KKIKKNKMTKMDARILGFSVTAAEGRINVG----IRDY 1570
...|.|:| ||.||.||.:.|..:|||||.|:..|:|:| :.||
Human 1266 TNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY 1320
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