DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gyf and Gigyf2

DIOPT Version :9

Sequence 1:NP_001162827.1 Gene:Gyf / 43842 FlyBaseID:FBgn0039936 Length:1574 Species:Drosophila melanogaster
Sequence 2:NP_666224.3 Gene:Gigyf2 / 227331 MGIID:2138584 Length:1291 Species:Mus musculus


Alignment Length:1714 Identity:398/1714 - (23%)
Similarity:621/1714 - (36%) Gaps:572/1714 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGREEML 66
            |.::.|||||||.:|:                    ||.......:.:..:....:|||||||||
Mouse     5 TQTLNFGPEWLRALSS--------------------GGSITSPPLSPALPKYKLADYRYGREEML 49

  Fly    67 SLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPSGFGSAS 129
            :||.::..:|..|  ..|..:..|:...||||.|.:||:....|:..||..........|.|...
Mouse    50 ALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTV 114

  Fly   130 RGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKA-------ERTWSDRN-------GT 180
            .|:.||.:..|||.||:... ..|||.   :||...|..:.       .::|.:|.       |.
Mouse   115 VGAPRGRSSSRGRGRGRGEC-GFYQRS---FDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGR 175

  Fly   181 GDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNL----ENWRRTRNEDGSGDGPSSSGSMSG 241
            .|........||         |:|..||     |..:    ||||..|.|....|          
Mouse   176 KDVGRPNFEESG---------PTSVGRK-----HEFIRSESENWRIFREEQNGED---------- 216

  Fly   242 PDIAGWRSGVVGGSTNAGFGTNSHRW-------GRSTSWRDEDPSVDNAASLQRSISTVATLSTD 299
             :..|||   :.||...|     .||       .|||.||:.       ...:|..........|
Mouse   217 -EDGGWR---LAGSRRDG-----ERWRPHSPDGPRSTGWREH-------MERRRRFEFDFRDRDD 265

  Fly   300 RTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPEWAIENPSKLGGSFDAS 364
            ..|..:     ...|.|||...|                     ::||||.:|:..:..|:||:|
Mouse   266 ERGYRR-----VRSGSGSIDDDR---------------------DSLPEWCLEDAEEEMGTFDSS 304

  Fly   365 GAF-------------HGDTDLKPIK---------SSHNTLKTKSLDSYDDVKRPKSKDLSDPDS 407
            |||             ..:.|.:|::         ||||                  ::..:||.
Mouse   305 GAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHN------------------EEAKEPDK 351

  Fly   408 GNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKEVIHGDISDRIKEVADEVEKLIMDDDHKI 472
            .|  ..|...|......|.:|..::|||....        |..||...:.|.:.|:.......::
Mouse   352 TN--RREGEKTDRAGAEASEEVPQTSLSSARP--------GTPSDHQPQEATQFERKDEPKAEQV 406

  Fly   473 SSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQAPST-MPIQITPTITDVAPPSHAVVSFS 536
            ...:.::::.:..:|.:|...|        .|....|.||| :|......:..::||.....|.|
Mouse   407 EKAEEENRSENSLSAKVPSRGD--------ETVPASQQPSTPLPPDTASPLLILSPPVPTPSSAS 463

  Fly   537 ---------------------DHETMQHHN------------------------MHHLPQFPMIP 556
                                 |.|.::|..                        ..|..:...||
Mouse   464 RPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIP 528

  Fly   557 TPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCH 621
            ..|    ...:.|:|:|||..:||||:..||.||::||||..:|.|:|..|..|:|||:::|. .
Mouse   529 LMH----EAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKM-W 588

  Fly   622 GNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQQQRDEQLKAN 686
            |.:||       ||        |..|.|....|.                :::|.:|::      
Mouse   589 GRVPF-------SP--------GPAPPPHMGELD----------------QERLTRQQE------ 616

  Fly   687 VTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQY----IQHQEYQILAELSKNECFQRLS 747
                                       ||..:||...||    ||.|..|:||:..|    ..||
Mouse   617 ---------------------------LTALYQMQHLQYQQFLIQQQYAQVLAQQQK----AALS 650

  Fly   748 AVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQR 812
            :.:|:                        .|::|     .|.::|:  ..:...|:|..:..:..
Mouse   651 SQQQQ------------------------QLALL-----LQQFQAL--KMRMSDQNIIPSVTRSV 684

  Fly   813 SVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLR 877
            ||.:               ..|..|:.| .:|...:.:||:..||......|...|:     .|:
Mouse   685 SVPD---------------TGSIWELQP-AASQPAVWEGGSVWDLPLDTTAPGPSLE-----QLQ 728

  Fly   878 MLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWLPPNNNKQQETDQQWAEM 942
            .|.:.:....:|:                 ..|.::..::.       .....:|:|..:|..|:
Mouse   729 QLEKAKAAKLEQE-----------------RREAEMRAKRE-------EEERKRQEELRRQQEEI 769

  Fly   943 SNADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQS 1007
                  |........:|.|:::|..:|..||.....|:::.:.                      
Mouse   770 ------LRRQQEEERKRREEEELARRKQEEALRRQREQEIALR---------------------- 806

  Fly  1008 PQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKR 1072
                                :|...||....:..:::..::....::...|..|.....|...|.
Mouse   807 --------------------RQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 851

  Fly  1073 EQTEEKKRQREERKRQQLEDDKRRALNESEEQTR---QIQEEK----ERQQQIQAQRRKALLGNV 1130
            .:.||:.::|.|..|.::|::..|..:|.||:.|   ::|.:|    :||||.:|.||       
Mouse   852 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRR------- 909

  Fly  1131 HSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPSTSVAPWSFQLQNS---MRSAPGLAEIQK 1192
                        |...|.:        :.....:|||:|.  |..|...:   .::...||||||
Mouse   910 ------------LQQQQQQ--------QQLAQMKLPSSST--WGQQSNTATCQSQATLSLAEIQK 952

  Fly  1193 -AERRER--RADQQRHQELLDKQLRANAAAAAEANDALLKW--QSTPASAPVMSLAEIQAEEARR 1252
             .|.|||  |.:|:|.|..|.|.|:..  ...:....|..|  .|.||.. ..||.|||.||||:
Mouse   953 LEEERERQLREEQRRQQRELMKALQQQ--QQQQQQQKLSGWGNVSKPAGT-TKSLLEIQQEEARQ 1014

  Fly  1253 LANDLVDRQRRRELEHHQQA----PLSSAVLVTSATSNIWGNAN----KAWSSSAAQSL---SLK 1306
            :...  .:|::::.:.|||:    ..:.:.|.||..:::||:.|    ..|:|....|:   :..
Mouse  1015 MQKQ--QQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADT 1077

  Fly  1307 TSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQ 1371
            .:|..|.||:                   |....|..||.||      ||::|      :|.|| 
Mouse  1078 KNSNMGFWDD-------------------AVKEVGPRNSTNK------NKNNA------SLSKS- 1110

  Fly  1372 TLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEY 1436
              ..:||  :.||                      .:||:::..||            ...||:.
Mouse  1111 --VGVSN--RQNK----------------------KVEEEEKLLKL------------FQGVNKA 1137

  Fly  1437 ENEFTSWCIKSLD--NMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRS 1499
            ::.||.||.:.|.  |.:..:||||||:||:::|:||||.||.|.||||..::.:|||||||||:
Mouse  1138 QDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRA 1202

  Fly  1500 KYK-----SLQRAQKAHNDDMCKPAPAITPSANDYADSKNKQ---------KKIKKNKMTKMDAR 1550
            |.|     ..|:.|:...|.:.....:...|......|.|:|         ||.||.||.:.|..
Mouse  1203 KQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPS 1267

  Fly  1551 ILGFSVTAAEGRINVG----IRDY 1570
            :|||||.|:..|:|:|    :.||
Mouse  1268 LLGFSVNASSERLNMGEIETLDDY 1291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GyfNP_001162827.1 GYF 566..621 CDD:238027 26/54 (48%)
PKK 998..1112 CDD:289257 19/116 (16%)
Gigyf2NP_666224.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..132 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..196 10/61 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..248 15/57 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 267..484 52/278 (19%)
DDX6 binding motif. /evidence=ECO:0000250|UniProtKB:Q6Y7W6 281..311 13/50 (26%)
PTZ00449 <330..>474 CDD:185628 32/179 (18%)
GYF 534..589 CDD:238027 26/55 (47%)
Required for GRB10-binding. /evidence=ECO:0000269|PubMed:12771153 548..564 9/15 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..794 11/91 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..937 30/119 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 958..998 12/41 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1053 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1090..1118 13/44 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1223 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1239..1263 9/23 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835510
Domainoid 1 1.000 157 1.000 Domainoid score I4151
eggNOG 1 0.900 - - E1_KOG1862
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 231 1.000 Inparanoid score I3426
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001680
OrthoInspector 1 1.000 - - otm42666
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14445
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R738
SonicParanoid 1 1.000 - - X2990
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.880

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