Protein Alignment Gyf and gyf-1

DIOPT Version :10

• Sequence 1: NP_001162827.1
• Gene: Gyf / 43842
• FlyBaseID: FBgn0039936
• Length: 1574
• Species: Drosophila melanogaster
• Sequence 2: NP_001343746.1
• Gene: gyf-1 / 174103
• WormBaseID: WBGene00016002
• Length: 1106
• Species: Caenorhabditis elegans
• Alignment Length: 1635
• Identity: 318/1635 - (19%)
• Similarity: 538/1635 - (32%)
• Gaps: 613/1635 - (37%)

  Fly     2 TDSMKFGPEW---LRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNN----------TAASASRN 53
            |....|.|..   :|..:|...||.|:.|  |.:.....||.:.|.:          .||..|..
 Worm    10 TAQQNFNPSCHFRMRPNAANRGGSISSGN--NRSSGFGGGGFDDGGDEISSSAIAAAAAAVLSSP 72

  Fly    54 LFPEYRYGREEMLSLFDRNCLLPQILPSFKKLFVEKVQCPL-ALTPSSE-EDINQNSLGNNSRPA 116
            :..|:.|.||.:|.|.....::|..|..  :||..:...|| :.||.|| |...|:::.::...:
 Worm    73 VVSEFSYTRERLLELAPTGSIMPDALRD--QLFFNEKNLPLVSNTPLSEHEQKLQHNINSSKAMS 135

  Fly   117 WLQRSPSGFGSASRGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKAERTWSDRNGTG 181
            .|..:                 ||..:...:||                             |:|
 Worm   136 LLSHA-----------------DRASIAAGAAY-----------------------------GSG 154

  Fly   182 DSAATTTSTSGSGALDWNGTPSS--SPRKDYSNNHRNLENWRRTRNEDGSGDGPSSSGSM---SG 241
            ..||       ||||....:|:|  :|:          .:|.:...:.|:|..|...||:   ||
 Worm   155 YGAA-------SGALQNGQSPTSRWAPK----------SSWNKGTPDRGTGTTPRGGGSVGRASG 202

  Fly   242 PDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLSTDRTGNNKG 306
            ...||...|.:||....|..||    |.|.:.::||              :..|..:......:|
 Worm   203 AFFAGRGGGRIGGENGFGGATN----GGSPAAQNED--------------SPGTYQSKFNALRRG 249

  Fly   307 SGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPEWAIENPSKLGGSFDASGAFHGDT 371
            .|.|:....||               |..:|....||      |:.||:
 Worm   250 GGAGSVGRGGS---------------TTGSAFNTRAD------ALYNPN---------------- 277

  Fly   372 DLKPIKSSHNTLKTKSLDSYDDVKRPKSKDLSDPDSGNDITPETSLTK--DTNTTAVQEEVESSL 434
                                |...|||:.:.:...|.:|...|...:|  .|:.|:.....:||.
 Worm   278 --------------------DPTDRPKAVNPAATRSESDEEEEEGWSKVGSTSRTSTNAAPQSSE 322

  Fly   435 SPISSTTTKEVIHGDISDRIKEVADEVEK----------LIMDDDHKISSNQSQHQNHDGFTAAL 489
            .|..:.:...:      .|.::...:.::          :.:.::.::.|:.:..::.:...||:
 Worm   323 RPAWARSESWI------QRTQQQQQQQQQQSTQQQAQPPITLWNNREVGSDSTVWKDRNHMVAAV 381

  Fly   490 PRMADIEINVKPSVTAVHRQ---APSTMPIQITPTITDVAPPSHAVVSF-SDHETMQHHNMHHLP 550
             |.|..| |..|......:|   ||.:.|.:.....|||  |:..:.:: ||.....:::|....
 Worm   382 -RKASTE-NHPPQQQQQQQQRSSAPVSAPSRQESESTDV--PNLPIPTYPSDPSAWSNNSMGGGI 442

  Fly   551 QFPMIPTPHIITPNLNE---LWFYRDPQANVQGPFSAVEMTEWYRAGYF-NENLFVRRYSDNRFR 611
            .:.  |||....|.:.|   .::|.||....:|||...:|..|::|||| :|:|.|:|..:..::
 Worm   443 FYQ--PTPQPPAPIVKEEPVQFYYMDPTETRRGPFPKDQMNVWFKAGYFTDESLRVQRGENGEYK 505

  Fly   612 PLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQ 676
            .:|:|.|....:.||.:         ||:|   :.|.|:..|:        |.|
 Worm   506 TIGDLKKLHGSSTPFEY---------LEDI---EPPRPILPSI--------PYP----------- 539

  Fly   677 QQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQEYQILAELSKNE 741
                                                                             
 Worm   540 ----------------------------------------------------------------- 539

  Fly   742 CFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFA 806
                                                 |..||     ||.|..
 Worm   540 -------------------------------------SATNP-----LYPAAF------------ 550

  Fly   807 NTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLI 871
                                                        ||                  :
 Worm   551 --------------------------------------------GG------------------V 553

  Fly   872 NEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWLPPNNNKQQETD 936
            |.::    ..||||......   ||            .|.||:..:|.:    |..:|.:..|..
 Worm   554 NMWS----SMGQPTDVYMMQ---TN------------FEQQLVAERNRL----LDDHNRRLAEEA 595

  Fly   937 QQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTAL 1001
            ::.|:..  :|...:....:|:|..:|:||:||.:|      |.:.:.|:..:.::..      |
 Worm   596 EKMAKFQ--EAMYRQLTMQHEQRVREQELLLQKRAE------EIEKREAESKREEAAR------L 646

  Fly  1002 EELDQSPQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINN 1066
            ::|:|..:.::    ::.......|.::...||.|    ::.:..|..:..|:.|
 Worm   647 QKLEQEAREIE----ERKAALEAEDRRKREIEEYN----RMCEKKKNEIIAKEAA---------- 693

  Fly  1067 ENDRKR-EQTEEKKRQREERKRQQLEDDKRRALNESEEQTRQIQEEKERQQQIQAQRRKALLGNV 1130
              ||.| |:..|::|:|.|.:.:..|:..||....:|.:.|:.:||::|     |..|:.:....
 Worm   694 --DRMRLEEATERERRRLEAESRVAEEKIRRDRVRAELEAREREEERKR-----AAERERIARET 751

  Fly  1131 HSLSVQNGMSGTLAS---AQSKKNDDAKTAEPQ---------------VSSRLPSTSVAPWSFQL 1177
            .||..|..:....|.   |....::.|.|..|:               .|..:..|..|||:.::
 Worm   752 ASLQQQAELDAAWAGKKIATVTTSNSAFTGAPKQVSPSGSEESDEWISTSKEVKHTKTAPWAAKV 816

  Fly  1178 QNSMRSAPGLAEIQKAERRERRADQQRHQELLDKQLRANAAAAAEANDALLKWQSTPASAPVMSL 1242
            :...:|...|.||||.|.|:.:.:|:::.:|..|:..:|..:||
 Worm   817 EAPQKSEKTLLEIQKEEERKFKVEQEKNAKLKAKEQASNITSAA--------------------- 860

  Fly  1243 AEIQAEEARRLANDLVDRQRRRELEHHQQAPLSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKT 1307
                     .:|.|                          .:..:|| |:|.|  :|.:|.|.|:
 Worm   861 ---------AIAGD--------------------------KSGGLWG-ASKTW--AAPESNSSKS 887

  Fly  1308 SSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQT 1372
            .....| |.|:                        |.:|||..||.:|..
 Worm   888 YVSPFL-DGPS------------------------LEAANKMALQKKNSQ--------------- 912

  Fly  1373 LPALSNPEKSNKNGPGQRPEKQKLA-QTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEY 1436
             |.::.|.||       .|...|:| ..::|..||::......:|.....:|.:||
 Worm   913 -PKIAVPAKS-------APTSAKVATPVKAKATAVAVSSPATNQKTKKTKEQVATD--------- 960

  Fly  1437 ENEFTSWCIKSLDNMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKY 1501
              |...|.:|.....|.:||..|....:..||.|.||:|.|..||.:.|...:|.::|::||...
 Worm   961 --ELQQWFVKRFQQFSTQVDSSTLFDCIMSLENPNEVEDIVMSYLDESKTVKEFVREFIKRRIAM 1023

  Fly  1502 KSLQRAQKAHNDDM-----CKPAPAITPSANDYADSKNKQKKIKKNKMTKMDARILGFSVTAAEG 1561
            ::......|  ||:     ...||:.:.|.::......:.||.||.:...:|..||||..|||..
 Worm  1024 RAAGGRPDA--DDLTSARTAAAAPSDSNSGSNSNSGNGQGKKKKKTQKQVLDGNILGFRGTAAAD 1086

  Fly  1562 RINVGIRDYV 1571
            |:|.|..|.|
 Worm  1087 RLNKGEIDAV 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	569..613	CDD:460496	16/44 (36%)
		Mplasa_alph_rch	<931..>1113	CDD:275316	38/182 (21%)
gyf-1	NP_001343746.1	GYF	460..516	CDD:214666	19/55 (35%)
		PTZ00121	<568..>964	CDD:173412	112/571 (20%)