DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyf and Gigyf2

DIOPT Version :9

Sequence 1:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster
Sequence 2:	XP_038940628.1	Gene:	Gigyf2 / 100362458	RGDID:	2318130	Length:	1323	Species:	Rattus norvegicus

Alignment Length:	1758	Identity:	404/1758 - (22%)
Similarity:	623/1758 - (35%)	Gaps:	628/1758 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGREEML 66
            |.::.|||||||.:|:                    ||.......:.:..:....:|||||||||
  Rat     5 TQTLNFGPEWLRALSS--------------------GGSITSPPLSPALPKYKLADYRYGREEML 49

  Fly    67 SLF-------DRNC---------------LLPQILPSFKKLFVEKVQCPLALTPSSEEDINQNSL 109
            :||       |..|               |..:.||    :..|:...||||.|.:||:....|:
  Rat    50 ALFLKDYKNKDTRCHAWLCLELFNIPFDLLEKEFLP----ILQEEPLPPLALVPFTEEEQRNFSM 110

  Fly   110 GNNSRPAWLQRSPSGFGSASRGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKA---- 170
            ..||..........|.|....|:.||.:..|||.||:... ..|||.   :||...|..:.
  Rat   111 SVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGEC-GFYQRS---FDEVEGVFGRGGGRE 171

  Fly   171 ---ERTWSDRN-------GTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNL----ENWR 221
               .::|.:|.       |..|........||         |:|..||     |..:    ||||
  Rat   172 MHRSQSWEERGDRRFEKPGRKDVGRPNFEESG---------PTSVGRK-----HEFIRSESENWR 222

  Fly   222 RTRNEDGSGDGPSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRW-------GRSTSWRDEDPS 279
            ..|.|....|           :..|||   :.||...|     .||       .|||.||:.
  Rat   223 IFREEQNGED-----------EDGGWR---LAGSRRDG-----ERWRPHSPDGPRSTGWREH--- 265

  Fly   280 VDNAASLQRSISTVATLSTDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADE 344
                ...:|..........|..|..:     ...|.|||...|                     :
  Rat   266 ----MERRRRFEFDFRDRDDERGYRR-----VRSGSGSIDDDR---------------------D 300

  Fly   345 NLPEWAIENPSKLGGSFDASGAF-------------HGDTDLKPIK---------SSHNTLKTKS 387
            :||||.:|:..:..|:||:||||             ..:.|.:|::         ||||
  Rat   301 SLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHN------ 359

  Fly   388 LDSYDDVKRPKSKDLSDPD-------SGNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKEV 445
                ::.|.|...:..|.:       ..|:..|:|||              ||..|
  Rat   360 ----EEAKEPDKTNRRDGEKTDRAGTDANEEVPQTSL--------------SSARP--------- 397

  Fly   446 IHGDISDRIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQA 510
              |..||...:.|.:.|:.......::...:.:.::.:...|.:|...|        .|....|.
  Rat   398 --GTPSDHQPQEAAQFERKDEPKAEQMEKAEEESRSENSLPAKIPSRGD--------ETVPASQQ 452

  Fly   511 PSTM-------PIQI------TPTITD-------VAPPSHAVVSF--SDHETMQHHN-------- 545
            |||.       |:.|      ||:...       |..|..:.||.  .|.|.::|..
  Rat   453 PSTQLPPDTASPLLILSPPLPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVA 517

  Fly   546 ----------------MHHLPQFPMIPTPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAG 594
                            ..|..:...:|..|    ...:.|:|:|||..|||||:..||.||::||
  Rat   518 YLQDSALDDERLTSKLQEHRAKGVSVPLVH----EAMQKWYYKDPQGEVQGPFNNQEMAEWFQAG 578

  Fly   595 YFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPH 659
            ||..:|.|:|..|..|:|||:::|. .|.:||       ||        |..|.|....|.
  Rat   579 YFTMSLLVKRACDESFQPLGDIMKM-WGRVPF-------SP--------GPAPPPHMGELD---- 623

  Fly   660 KPSPIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQ 724
                        :::|.:|::                                 ||..:||...|
  Rat   624 ------------QERLTRQQE---------------------------------LTALYQMQHLQ 643

  Fly   725 Y----IQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVA 785
            |    ||.|..|:||:..|    ..||:.:|:                        .|::|
  Rat   644 YQQFLIQQQYAQVLAQQQK----AALSSQQQQ------------------------QLALL---- 676

  Fly   786 GRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQ 850
             .|.::|:  ..:...|:|..:..:..||.:               ..|..|:.| .:|...:.:
  Rat   677 -LQQFQAL--KMRMSDQNIIPSVTRSVSVPD---------------TGSIWELQP-AASQPAVWE 722

  Fly   851 GGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLE 915
            ||:..||......|...|:     .|:.|.:.:....:|:                 ..|.::..
  Rat   723 GGSVWDLPLDTTTPGPSLE-----QLQQLEKAKAAKLEQE-----------------RREAEMRA 765

  Fly   916 RQNLMIPIWLPPNNNKQQETDQQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACFADTEK 980
            ::.       .....:|:|..:|..|:      |........:|.|:::|..:|..||.....|:
  Rat   766 KRE-------EEERKRQEELRRQQEEI------LRRQQEEERKRREEEELARRKQEEALRRQREQ 817

  Fly   981 DVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQA 1045
            ::.:.                                          :|...||....:..:::.
  Rat   818 EIALR------------------------------------------RQREEEERQQQEEALRRL 840

  Fly  1046 NKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQREERKRQQLEDDKRRALNESEEQTR---Q 1107
            .::....::...|..|.....|...|..:.||:.::|.|..|.::|::..|..:|.||:.|   :
  Rat   841 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 905

  Fly  1108 IQEEK----ERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPST 1168
            :|.:|    :||||.:|.||                   |...|.:        :.....:|||:
  Rat   906 LQRQKDLMRQRQQQQEALRR-------------------LQQQQQQ--------QQLAQMKLPSS 943

  Fly  1169 SVAPWSFQLQNS---MRSAPGLAEIQK-AERRER--RADQQRHQELLDKQLRANAAAAAEANDAL 1227
            |.  |..|...:   .::...|||||| .|.|||  |.:|:|.|..|.|.|:..  ...:....|
  Rat   944 ST--WGQQSNTTTCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ--QQQQQQQKL 1004

  Fly  1228 LKW--QSTPASAPVMSLAEIQAEEARRLANDLVDRQRRRELEHHQQA----PLSSAVLVTSATSN 1286
            ..|  .|.||.. ..||.|||.||||::..   .:|::::.:.|||:    ..:.:.|.||..::
  Rat  1005 SGWGNVSKPAGT-TKSLLEIQQEEARQMQK---QQQQQQQQQQHQQSNRARNSTHSNLHTSIGNS 1065

  Fly  1287 IWGNAN----KAWSSSAAQSL---SLKTSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLN 1344
            :||:.|    ..|:|....|:   :...:|..|.||:                   |....|..|
  Rat  1066 VWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDD-------------------AVKEVGPRN 1111

  Fly  1345 SANKSTLQAQNKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIE 1409
            |.||      ||::|      :|.||   ..:||  :.||                      .:|
  Rat  1112 STNK------NKNNA------SLSKS---VGVSN--RQNK----------------------KVE 1137

  Fly  1410 EKDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLD--NMSAKVDVPTFVAFLQDLEAPYE 1472
            |:::..||            ...||:.::.||.||.:.|.  |.:..:||||||:||:::|:|||
  Rat  1138 EEEKLLKL------------FQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYE 1190

  Fly  1473 VKDYVRIYLGDGKDSLDFAKQFLERRSKYKS----------------------LQRAQKAHNDDM 1515
            |.||.|.||||..::.:|||||||||:|.|:                      .|:.|:...|.:
  Rat  1191 VHDYTRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQDSV 1255

  Fly  1516 CKPAPAITPSANDYADSKNKQ---------KKIKKNKMTKMDARILGFSVTAAEGRINVG----I 1567
            .....:...|......|.|:|         ||.||.||.:.|..:|||||.|:..|:|:|    :
  Rat  1256 WGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETL 1320

  Fly  1568 RDY 1570
            .||
  Rat  1321 DDY 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	27/54 (50%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	19/116 (16%)
Gigyf2	XP_038940628.1	PHA03169	346..>513	CDD:223003	39/209 (19%)
Gigyf2	XP_038940628.1	GYF	550..605	CDD:238027	27/55 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm44731
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910