DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyf and gigyf1b

DIOPT Version :9

Sequence 1:	NP_001162827.1	Gene:	Gyf / 43842	FlyBaseID:	FBgn0039936	Length:	1574	Species:	Drosophila melanogaster
Sequence 2:	XP_005172689.1	Gene:	gigyf1b / 100002679	ZFINID:	ZDB-GENE-091204-310	Length:	1011	Species:	Danio rerio

Alignment Length:	1673	Identity:	344/1673 - (20%)
Similarity:	512/1673 - (30%)	Gaps:	798/1673 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSMKFGPEWLRNMS-----AEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGR 62
            :::.|||||||.:|     ..|..||                         :..::...:|||||
Zfish     4 ETLNFGPEWLRALSRGASVTSPPPSP-------------------------AMPKSKLADYRYGR 43

  Fly    63 EEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPSGF 125
            ||||:|:.::..:|:.:  ..|..:..::.|.||||.|.:||:....|:..|| .|.|:....|.
Zfish    44 EEMLALYVKDNKIPEDMQDKEFAAILQDEPQQPLALVPLTEEEQRNFSMSVNS-VAVLRLMGKGG 107

  Fly   126 GSA------SRGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKAE----RTWSDRNGT 180
            |:.      .|||.|||   |||.||:..:   |||.   .||.:......|    ::|.|| |.
Zfish   108 GAVPTGVARGRGSTRGG---RGRGRGEGGF---YQRS---VDEEVGFGRGREMHRSQSWDDR-GE 162

  Fly   181 GDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTRNEDGSGDGPSSSGSM------ 239
            ...........|.|..:.:|..:   ||||:.:  :.:|||..|.|....:..:..|..
Zfish   163 RRFEKPLRREVGRGGFEDSGAVA---RKDYARS--DSDNWRTLREEQEEEEAAAEPGGSWRIAGG 222

  Fly   240 ----SGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLSTDR 300
                .||..||||..:.|......|         ...:||.:
Zfish   223 RRDDGGPRSAGWREHISGEGRRRKF---------DFDFRDGE----------------------- 255

  Fly   301 TGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPEWAIENPSKLGGSFDASG 365
             |..:.:|   :||                        |.:..:.||||..:......|:||:||
Zfish   256 -GGRRRAG---SEG------------------------GEEERDGLPEWCTDEEEGEMGTFDSSG 292

  Fly   366 AFH-----------------------------------------------GDTDLKPIKSSHNTL 383
            ||.                                               .|.|.|.:.||.:.:
Zfish   293 AFMCIKKNSRDAILEDQELEFEALEEEEECCQEKKDSPADKLEECEAATVYDGDRKSLSSSPHAV 357

  Fly   384 KTKS--LDSYDDVKRP--KSKDLSDPDSGNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKE 444
            ...:  |.|..:..:|  .......|....|..|.:..|..|:         ||..|.|:.|...
Zfish   358 SVPAAVLPSEQETPKPIIVPPPKPAPQPAEDAVPASGTTSQTH---------SSSPPSSTATDLP 413

  Fly   445 VIHGDI--SDRIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVH 507
            .:.||.  .|.:|.:..|.||:       ::|.|......:.||.||.         :..::|.|
Zfish   414 AVGGDTEEEDGMKHLQQEAEKM-------VASLQDTSLEEECFTHALQ---------ESHISAAH 462

  Fly   508 RQAPSTMPIQITPTITDVAPPSHAVVSFSDHETMQHHNMHHLP-QFPMIPTPHIITPNLNELWFY 571
                           |...|.:|         |:.|...|.|| ....:|..|.....    |||
Zfish   463 ---------------THTHPNTH---------TLSHSTPHTLPHSASALPLSHESAMK----WFY 499

  Fly   572 RDPQANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPI 636
            :|||..:||||:.|||.||::||||..||.|:|..|..|:||||:||. .|.:||       ||
Zfish   500 KDPQGEIQGPFTTVEMCEWFQAGYFAMNLLVKRGCDEGFQPLGEVIKM-WGRVPF-------SP- 555

  Fly   637 ELENIPVGQIPAPLTASLSITPHKPSPIPIAL---SVVEQQLQQQRDEQLKANVTATAEALRAAI 698
                                   .|||.|:.:   ..::|:|.:::.||          |..||:
Zfish   556 -----------------------GPSPPPLLVRDKGNMDQELLKKQLEQ----------AATAAL 587

  Fly   699 KGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLG 763
                               :|.||.:                  ||.:::...||         |
Zfish   588 -------------------YQQLQMR------------------FQHMNSRCSET---------G 606

  Fly   764 LPEYLISLNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQ 828
            :      :..::.|:||
Zfish   607 M------MPAMNRSMSV------------------------------------------------ 617

  Fly   829 IMIQQSQQEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPA 893
                   .:.||:..                                       .|||..||
Zfish   618 -------PDTGPMWD---------------------------------------MPTSVSQQ--- 633

  Fly   894 LTNSATENLPGVDFLTETQLLERQNLMIPIWLPPNNNKQQETDQQWAEMSNADASLWETANLNEE 958
                                                             |..:.|||:..
Zfish   634 -------------------------------------------------SGGETSLWDLT----- 644

  Fly   959 RNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQKIVKSL 1023
                                                         :..|.|.....|.|||
Zfish   645 ---------------------------------------------MSNSTQGPTLEHLQKI---- 660

  Fly  1024 VSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQREERKRQ 1088
                                         :|...::.|:....|.:|||.  |||:||:||:||:
Zfish   661 -----------------------------QQERREAELRVKREEEERKRR--EEKRRQQEEQKRR 694

  Fly  1089 QLEDDKRRALNESEEQTRQIQE-----EKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQS 1148
            :.|:..|:     ::|.||.||     .::.|||              |:|..:|.||:...|.|
Zfish   695 EEEEIYRK-----KQQCRQQQELIMKFLQQSQQQ--------------SMSGSSGWSGSQTGALS 740

  Fly  1149 KKNDDAKTAEPQVSSRLPSTSVAPWSFQLQNSMRSAPGLAEIQKAER-----RERRADQQRHQEL 1208
                                        |..:...:.||.|:: |||     ::|...||||..|
Zfish   741 ----------------------------LGKATGKSMGLLELE-AERIHKQQQQRAQQQQRHGGL 776

  Fly  1209 LDKQLRANAAAAAEANDALLKWQSTPASAPVMSLAEIQAEEARRLANDLVDRQRRRELEHHQQAP 1273
                             .:.:|...|:.
Zfish   777 -----------------TMGQWNDGPSG------------------------------------- 787

  Fly  1274 LSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKTSSGT---GLWDEPNPLGSNGSGTSGTSSVTA 1335
                                .||.|   |:..|...|.   |:|||
Zfish   788 --------------------MWSGS---SMDGKVGGGNPAMGMWDE------------------- 810

  Fly  1336 AAVLAGGLNSANKSTLQAQNKSSALFASPRN--LRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQ 1398
                            ..:|:|     |.||  ||.|::.|:||:....|:.
Zfish   811 ----------------AMKNQS-----SHRNIGLRNSRSSPSLSDQYMLNRR------------- 841

  Fly  1399 TRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLDNM-----SAKVDVP 1458
                      :..|.|.:| .|..|....|         :.||:||.:.|..:     :|.:|||
Zfish   842 ----------KRTDEEERL-LKLLQGMKPQ---------DGFTTWCEQMLHALNTSANNASLDVP 886

  Fly  1459 TFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYK-SLQRAQKAHNDDMCK----- 1517
            |.||:|:::|:||||.|::||||||..::.:|||||||||:|.| :.||.|:..::.:.|
Zfish   887 TIVAYLKEVESPYEVHDFIRIYLGDTIEAKEFAKQFLERRAKQKANHQRQQQQVSERLSKEVSGL 951

  Fly  1518 ----------PAPAITPSANDYADSKNKQKKIKKNKMTKMDARILGFS 1555
                      .|..|:...:.|.....|.|| |.:.|...|..|||:|
Zfish   952 NMNFPLQSMFQAAHISKGGSVYDTQGGKAKK-KPSMMLHSDPSILGYS 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyf	NP_001162827.1	GYF	566..621	CDD:238027	31/54 (57%)
Gyf	NP_001162827.1	PKK	998..1112	CDD:289257	28/118 (24%)
gigyf1b	XP_005172689.1	GYF	495..549	CDD:238027	31/58 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578719
Domainoid	1	1.000	84	1.000	Domainoid score	I8184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2780
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001680
OrthoInspector	1	1.000	-	-		otm26306
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14445
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R738
SonicParanoid	1	1.000	-	-		X2990
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.020