Protein Alignment unc-13 and QKY

DIOPT Version :9

• Sequence 1: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Sequence 2: NP_177610.1
• Gene: QKY / 843811
• AraportID: AT1G74720
• Length: 1081
• Species: Arabidopsis thaliana
• Alignment Length: 1184
• Identity: 220/1184 - (18%)
• Similarity: 376/1184 - (31%)
• Gaps: 378/1184 - (31%)

  Fly  2156 SKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSS- 2219
            |:...|:.:.|:.|:.::.||..|:|..||.|.....||||.|..::|||:|||...|...:..
plant    13 SRIQRKLVVEVVEARNILPKDGQGSSSAYVVVDFDAQKKRTSTKFRDLNPIWNEMLDFAVSDPKN 77

  Fly  2220 ---DRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLS--GEMD-VWYNLEKRTDKSAV 2278
               |.:.:.|:::........|:      :.|||:..|.....|  ||.. |::.|||::..|.:
plant    78 MDYDELDIEVYNDKRFGNGGGRK------NHFLGRVKIYGSQFSRRGEEGLVYFPLEKKSVFSWI 136

  Fly  2279 SGAIRLHISV--EIKGEEKVA----------------PYHVQYTCLHENLFHYLCEENTGMVKLP 2325
            .|.|.|.|..  |...|:...                |........|:..||...::   |:.:|
plant   137 RGEIGLKIYYYDEAADEDTAGGGGGQQQQQQQQQFHPPQQEADEQQHQQQFHPPPQQ---MMNIP 198

  Fly  2326 TQKG-----------DDAWKLYFDEI----PEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPG 2375
            .:|.           :.|....:.|.    |..||:|...::.::.......|.:. :.....|.
plant   199 PEKPNVVVVEEGRVFESAQSQRYTETHQQPPVVIVEESPPQHVMQGPNDNHPHRND-NHPQRPPS 262

  Fly  2376 VPAVMSTLLANINAYYAHTTASSAVS---ASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNN 2437
            .|...|   |....||........|.   ..||           :::..:..|.   |.|....|
plant   263 PPPPPS---AGEVHYYPPEVRKMQVGRPPGGDR-----------IRVTKRPPNG---DYSPRVIN 310

  Fly  2438 FPASSPEKLMDLKS--TVDLLTSITFFRMK-VQELSSPPRASTVVKDCVKACLRSTYQFLFENCY 2499
            ......|..|:.|:  ..:|:..:.:..:: |:....||..|..||      :|::..|:  ...
plant   311 SKTGGGETTMEKKTHHPYNLVEPMQYLFVRIVKARGLPPNESAYVK------VRTSNHFV--RSK 367

  Fly  2500 ELYNREFQVDPNEAKRAPDDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQL 2564
            ...||     |.|:..:|:           |:::.||       ..|...:.:.....|::....
plant   368 PAVNR-----PGESVDSPE-----------WNQVFAL-------GHNRSDSAVTGATLEISAWDA 409

  Fly  2565 SASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEP 2629
            |:.|.......|:                                 .|||     |.|.|.  .|
plant   410 SSESFLGGVCFDL---------------------------------SEVP-----VRDPPD--SP 434

  Fly  2630 FVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPE 2694
            ...||..         |.|: ..|:..| :.|.:..|    .|.:.||:.:.|          ||
plant   435 LAPQWYR---------LEGS-GADQNSG-RISGDIQL----SVWIGTQVDEAF----------PE 474

  Fly  2695 IWKRYMRRFAKTIVKVL----IAYADIVKLEFPEHMKDERIACILMN-NIQQLRVQLEKMFES-- 2752
            .|.......|.|..||.    :.|..:..||    .:|..||..|.. ...::||:.:..|:|
plant   475 AWSSDAPHVAHTRSKVYQSPKLWYLRVTVLE----AQDLHIAPNLPPLTAPEIRVKAQLGFQSAR 535

  Fly  2753 ---------MGGDKLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIK- 2807
                     .|.....||...:..|       .|:|.   ..:.:|.|.|:....||..::.:.
plant   536 TRRGSMNNHSGSFHWHEDMIFVAGE-------PLEDC---LVLMVEDRTTKEATLLGHAMIPVSS 590

  Fly  2808 -------------------------GGSGTLAAGNLAAQRNAVAVEADEVLRPLMDLLDGS---L 2844
                                     ||.|....|........:::..         .|:|.   |
plant   591 IEQRIDERFVPSKWHTLEGEGGGGGGGGGPGGGGGGGPYCGRISLRL---------CLEGGYHVL 646

  Fly  2845 TLYAQSCEKTVLKRLLKELWKIVMRILEKTIV----LPPM---------TDKTMMFKHLTDNAKN 2896
            ...|..|..  .:...|:|||..:.|||..|:    |.||         ||...:.|:
plant   647 EEAAHVCSD--FRPTAKQLWKPPIGILELGILGARGLLPMKAKNGGKGSTDAYCVAKY------- 702

  Fly  2897 LASNAKIEDMGRLFKSHMAGKQDVKSALSGVMDISKEVEKNLSPK-----------QCAVLDVAL 2950
                               ||:.|:         ::.:..:..|:           .|.||.|.:
plant   703 -------------------GKKWVR---------TRTITDSFDPRWHEQYTWQVYDPCTVLTVGV 739

  Fly  2951 -DTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEESVG 3014
             |..:.:..|.         :..|:.:..:..:.:.|..::   |.:.:|....|.|.:..:.:|
plant   740 FDNWRMFSDAS---------DDRPDTRIGKIRIRVSTLESN---KVYTNSYPLLVLLPSGMKKMG 792

  Fly  3015 EISVQIDLFSHPGT--------GE------HKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHL 3065
            ||.|.: .|:.|..        |:      |.:....||..|......:.|...:  :....|.|
plant   793 EIEVAV-RFACPSLLPDVCAAYGQPLLPRMHYIRPLGVAQQDALRGAATKMVAAW--LARAEPPL 854

  Fly  3066 QEKKRKFATKSKSNNWSPKYNES--------FSFTIGNEEQLD---------------------- 3100
            ..:..::...:.|:.||.:.:::        .::.:|..:.||
plant   855 GPEVVRYMLDADSHAWSMRKSKANWYRIVGVLAWAVGLAKWLDNIRRWRNPVTTVLVHILYLVLV 919

  Fly  3101 -----------FFELHICVKDYCF------ARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEM 3148
                       .:.:.|.|..|.|      ..|.||.....:...::.|:...   :|..||.|:
plant   920 WYPDLVVPTAFLYVVMIGVWYYRFRPKIPAGMDIRLSQAETVDPDELDEEFDT---IPSSRRPEV 981

  Fly  3149 DETGWTILRILSQR 3162
            ....:..||||:.|
plant   982 IRARYDRLRILAVR 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996
		C2B_Munc13	2160..2286	CDD:175993	40/132 (30%)
		DUF1041	2477..2584	CDD:283860	17/106 (16%)
		Membr_traf_MHD	2832..2992	CDD:287505	31/187 (17%)
		C2C_Munc13	3032..3152	CDD:176041	24/166 (14%)
QKY	NP_177610.1	C2A_MCTP_PRT_plant	18..148	CDD:175989	41/135 (30%)
		C2B_MCTP_PRT_plant	336..466	CDD:176024	37/215 (17%)
		C2C_MCTP_PRT_plant	498..658	CDD:175986	31/184 (17%)
		C2D_MCTP_PRT_plant	670..797	CDD:176025	29/173 (17%)
		PRT_C	926..1080	CDD:337028	17/73 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920