DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and AT1G51570

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_175568.1	Gene:	AT1G51570 / 841582	AraportID:	AT1G51570	Length:	776	Species:	Arabidopsis thaliana

Alignment Length:	496	Identity:	103/496 - (20%)
Similarity:	178/496 - (35%)	Gaps:	140/496 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2078 KCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVF----SVEEK 2138
            |.|||:..|.:.|.....::.......:|.:.....|::..:.:|.: .||:.||:    :.|..
plant   107 KDKDLVKDDLIGRVVFDLNEIPKRVPPDSPLAPQWYRLEDGKGQKVK-GELMLAVWFGTQADEAF 170

  Fly  2139 SHAGHMKAVKQSVLDGTSKWSAKI---------AITVICAQGLIAKDKSGTSDPYVTVQVSKVKK 2194
            ..|.|..|...|..|..:...:|:         .:.||.||.||..||....:.:|.|.:.....
plant   171 PEAWHSDAATVSGTDALANIRSKVYLSPKLWYLRVNVIEAQDLIPSDKGRYPEVFVKVIMGNQAL 235

  Fly  2195 RTR-TMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRT 2258
            ||| :..:.:||:|||...|        :....::|  .|...:..::....|:.||:..:.::.
plant   236 RTRVSQSRSINPMWNEDLMF--------VVAEPFEE--PLILSVEDRVAPNKDEVLGRCAVPLQY 290

  Fly  2259 LSGEMDV------WYNLEKRT-----DKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFH 2312
            |....|.      |:||||..     :|..:..|.::|:.:.::|     .|||    |.|:. |
plant   291 LDKRFDYRPVNSRWFNLEKHVIMEGGEKKEIKFASKIHMRICLEG-----GYHV----LDEST-H 345

  Fly  2313 Y----------LCEEN-----------TGMVKLPTQKG----DDAWKL--YFDE--IPEEIVDEF 2348
            |          |.:.|           ||::.:..::|    .||:.:  |..:  ....|:|.|
plant   346 YSSDLRPTAKQLWKPNIGVLELGVLNATGLMPMKAKEGGRGTTDAYCVAKYGQKWIRTRTIIDSF 410

  Fly  2349 SMRYGIENIYQAM-------------THFHCLSAKYLCPG---------------VPAVMSTLLA 2385
            :.|:..:..::..             .|.|         |               |...:|||.|
plant   411 TPRWNEQYTWEVFDPCTVVTVGVFDNCHLH---------GGDKNNGGGKDSRIGKVRIRLSTLEA 466

  Fly  2386 NINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLS-----MYRNNFPA----- 2440
              :..|.|:.....:..|.            ||.:.::|.::|...|     ||..:.|.
plant   467 --DRVYTHSYPLLVLHPSG------------VKKMGEIHLAVRFTCSSLLNMMYMYSMPLLPKMH 517

  Fly  2441 -SSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVK 2480
             ..|..:..|.:.....|.|...|:...|   ||....||:
plant   518 YLHPLTVSQLDNLRHQATQIVSTRLTRAE---PPLRKEVVE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	4/8 (50%)
		C2B_Munc13	2160..2286	CDD:175993	34/146 (23%)
		DUF1041	2477..2584	CDD:283860	2/4 (50%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
AT1G51570	NP_175568.1	C2B_MCTP_PRT_plant	40..164	CDD:176024	13/57 (23%)
		C2C_MCTP_PRT_plant	202..352	CDD:175986	42/169 (25%)
		C2D_MCTP_PRT_plant	364..493	CDD:176025	24/151 (16%)
		PRT_C	621..776	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920