Protein Alignment unc-13 and AT1G03370

DIOPT Version :10

• Sequence 1: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Sequence 2: NP_171836.3
• Gene: AT1G03370 / 839519
• AraportID: AT1G03370
• Length: 1020
• Species: Arabidopsis thaliana
• Alignment Length: 1078
• Identity: 209/1078 - (19%)
• Similarity: 325/1078 - (30%)
• Gaps: 448/1078 - (41%)

  Fly  2161 KIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVR 2225
            |:.:.|:.|:.|.|.|.:|.|||||.:|:.|.:.||:.:.:.|||.|.|.|.|...:.:|.:.|.
plant     2 KLQVRVVEARNLPAMDLNGFSDPYVRLQLGKQRSRTKVVKKNLNPKWTEDFSFGVDDLNDELVVS 66

  Fly  2226 VWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMD-----VWYNLE-KRTDKSAVSGAIRL 2284
            |.|||...           :|||:||..:.|..:....:     |||.|. |:.......|.|.|
plant    67 VLDEDKYF-----------NDDFVGQVRVSVSLVFDAENQSLGTVWYPLNPKKKGSKKDCGEILL 120

  Fly  2285 HI----------------------SVEIKGEEKVAPYHVQYTCLHENLFHYLCEENTGMVKLPTQ 2327
            .|                      |.:::.|..:.|    .||...:
plant   121 KICFSQKNSVLDLTSSGDQTSASRSPDLRLESPIDP----STCASPS------------------ 163

  Fly  2328 KGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYA 2392
            :.|||     ..||:   ..|:.|:  ..|:|.                           ||..|
plant   164 RSDDA-----SSIPQ---TTFAGRF--TQIFQK---------------------------NAITA 191

  Fly  2393 HTTASS--AVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDL 2455
            ..|.||  ::.|||   .|...|..|         ||
plant   192 TPTQSSSRSIDASD---LSEISKPVF---------SL---------------------------- 216

  Fly  2456 LTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDH 2520
                        |||....:||..::.:||.                         |:|....:.
plant   217 ------------ELSEDESSSTSFEELLKAM-------------------------ESKDQGSEP 244

  Fly  2521 EPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQF----PQELNIGQLSASSMWHLFAVDMKYAL 2581
            ...|                      |.|.|::|.    |.:|||         .|||.|
plant   245 PSNL----------------------SGGVVVDQLFMISPSDLNI---------VLFASD----- 273

  Fly  2582 EEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLE-- 2644
                      ||.|.:|                      .:.....|..:..|..|||..|::
plant   274 ----------SSFYASL----------------------TELQGTTEVQIGPWKAENDGESVKRV 306

  Fly  2645 --YLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTI 2707
              ||..|.|..|.   .|.:|...:..:..:|:.       |::.:..||..        |..|.
plant   307 VSYLKAATKLIKA---VKGTEEQTYLKADGEVYA-------VLASVATPDVP--------FGGTF 353

  Fly  2708 VKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQN 2772
             ||.:.|......|.|...:..|:......|..|     ..|...|    :|..|       :|.
plant   354 -KVEVLYCISPGPELPSGEQCSRLVVSWRLNFLQ-----STMMRGM----IENGA-------RQG 401

  Fly  2773 LNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQRNAVAVEADEVLRPLM 2837
            |....:..|:..|.|::|..::.:           |.:...|..:|.|:             |..
plant   402 LKDNFEQYANLLAQSVKPVDSKDI-----------GLNKEQALSSLQAE-------------PQS 442

  Fly  2838 DLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPMTDKTMMFKHLTDNAKNLASNAK 2902
            |                         ||:.::......||........:|.|:
plant   443 D-------------------------WKLAVQYFANFTVLSTFLIGIYVFVHI------------ 470

  Fly  2903 IEDMGRLFKSHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKT 2967
                  :|.        :.||:.|       :|.|       .||:. |:|.::..:|
plant   471 ------VFA--------IPSAIQG-------LEFN-------GLDLP-DSIGEFVVSG------- 499

  Fly  2968 FLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEESVGEISVQIDLFSHPGTGEHK 3032
                         .|.|..:....||..|:.::..    :.|:..:.         :| |.| ..
plant   500 -------------VLVLQCERVLQLISRFMQARKQ----KGSDHGIK---------AH-GDG-WL 536

  Fly  3033 VNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSF------ 3091
            :.|.::...||....|||...|::.....|     |.|..:.|.:.:|  |::||.|.|
plant   537 LTVALIEGVDLAAVDPSGHCDPYIVFTSNG-----KTRTSSIKFQKSN--PQWNEIFEFDAMADP 594

  Fly  3092 -TIGNEEQLDF---FELHICV--KDYCFARDDRLVGVAVIPLKDI----SEKGSVACWLPLMRRI 3146
             ::.|.|..||   |:..:.:  .:..|.|.:      :..|.|:    ..|.:.||...|..||
plant   595 PSVLNVEVFDFDGPFDEAVSLGHAEVNFVRSN------ISDLADVWVPLQGKLAQACQSKLHLRI 653

  Fly  3147 EMDET-GWTILRILSQRNNDEVAKEFVKLKSEIRQEPT 3183
            .:|.| |..::|....:...||.|     |..:|...|
plant   654 FLDHTGGGDVVRDYLNKMEKEVGK-----KINVRSPQT 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2019..2100	CDD:412127
		C2B_Munc13	2160..2286	CDD:175993	43/130 (33%)
		MUN	2477..2996	CDD:461870	86/526 (16%)
		C2C_Munc13	3032..3152	CDD:176041	34/136 (25%)
AT1G03370	NP_171836.3	C2	2..104	CDD:425499	38/112 (34%)
		VASt	252..401	CDD:464975	45/229 (20%)
		C2	535..637	CDD:425499	26/114 (23%)
		PH-GRAM_C2-GRAM	699..812	CDD:270039
		VASt	851..992	CDD:464975