DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-13 and AT1G04150

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_171911.1	Gene:	AT1G04150 / 839249	AraportID:	AT1G04150	Length:	1012	Species:	Arabidopsis thaliana

Alignment Length:	994	Identity:	181/994 - (18%)
Similarity:	307/994 - (30%)	Gaps:	370/994 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2155 TSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSS 2219
            |...:.::.:.::.|..|:.||...:|.|:|.||....:.||:..|::|||:||||..|...:.:
plant     6 TGTGNERLVVEIVGAHNLMPKDGEDSSSPFVEVQFENQRLRTKVKPKDLNPIWNEKLVFHVIDVN 70

  Fly  2220 D----RIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTL------SGEMDV-WYNLEKRT 2273
            |    .:::.|::|          |.:..|.:|||    :||.|      .||..| .|.||||:
plant    71 DLRHKALEINVYNE----------KRSSNSRNFLG----KVRVLGSSVGREGESVVQLYTLEKRS 121

  Fly  2274 DKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYL--CEENTGMVKLPTQKGDDAWKLY 2336
            ..|:|.|    .|||:                      ||:  ..||...|:...:.|.
plant   122 LFSSVRG----EISVK----------------------HYMTTTAENGENVRRVNRSGG------ 154

  Fly  2337 FDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVS 2401
                                           |.|          |..:.|:       ::|.|:.
plant   155 -------------------------------SKK----------SKKVQNV-------SSSMAIQ 171

  Fly  2402 ASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNN---------FPASSPEKLMDLKSTVDLLT 2457
            ...:......          .|||..|.:....:.|         :|..|     ::|..|
plant   172 QQQQQQQQQI----------SLHNHNRGNQQQSQQNGQGQRMLPFYPHQS-----EIKPLV---- 217

  Fly  2458 SITFFRMKVQELSSP-----PR--------ASTVVKDCVKACLRSTYQFLFENCYELYNREFQVD 2509
                    :..|.||     ||        :...:|: .|.||..|
plant   218 --------ITALPSPMPGPGPRPIVYSNGSSEFSLKE-TKPCLGGT------------------- 254

  Fly  2510 PNEAKRAPDDHEPKLDSV-DFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQL--------- 2564
             :........|:.|..|. |...::..|.|:::   |....:||.:...|:.:|..
plant   255 -SNGLGGLSSHKDKTSSTYDLVEQMQYLYVNIV---KAKDLSVLGEVVSEVKLGNYRGVTKKVSS 315

  Fly  2565 -SASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFE 2628
             |::..|:...|..|..::........|.........||.:..|.....|||           ..
plant   316 NSSNPEWNQVFVFSKERIQSSVVELFVKEGNKDEYTGRVLFDLSEIPTRVPP-----------DS 369

  Fly  2629 PFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSE---HALFSNSVVDVFTQ----------LTQ 2680
            |...||               :|.:.::|.:.:.|   ...|.....:.|.:          :.:
plant   370 PLAPQW---------------YKIENRNGGRGNGELMVSVWFGTQADEAFAEAWHSKAGNVHIEE 419

  Fly  2681 CFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQ 2745
            ...:.||:.. .|::|  |:|........|.|.......:.|||      ::..|....|.||..
plant   420 LSSIKSKVYL-SPKLW--YLRISVIEAQDVAIMDKGSSLMRFPE------LSAKLQVGSQILRTA 475

  Fly  2746 LEKMF--ESMGGDKLEEDAANILKE---------LQQNLNSALDDLASQFAIS-LEPRITQSVRE 2798
            :....  :|.......||...::.|         ::..||.......:..|:. ::..|:...|.
plant   476 IASAIPTKSFSNPYWNEDLMFVVAEPFEDCVTVVVEDRLNGGAIGGQNDVAVGRVQIPISAVERR 540

  Fly  2799 LGDMLL-----SIKGGSGTLAAGNLAAQRNAVAVEADEVLRPLMDLLDG------SLTLYAQSCE 2852
            .||.|:     |:..|:.....|:....|.:               |||      ..|:|.....
plant   541 TGDTLVGSRWFSLDNGNNNNRFGSRIHLRLS---------------LDGGYHVLDEATMYNSDVR 590

  Fly  2853 KTVLKRLLKELWKIVMRILEKTIV----LPPMTDKTMMFKHLTDNAKNLASNAKIED--MGRLFK 2911
            .|.     |||||..:.:||..|:    |.||                     |:.|  .|.:..
plant   591 PTA-----KELWKPQVGLLEIGILSATGLMPM---------------------KVRDGKCGGIAD 629

  Fly  2912 SHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQ 2976
            |:...|...|...      ::.|..:|.||                                  .
plant   630 SYCVAKYGPKWVR------TRTVVDSLCPK----------------------------------W 654

  Fly  2977 SLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEE-SVGEISVQID--------------LFSHP 3026
            :.:|...:|...|...:..|.:::|:|.:  ||.: .:|::.:::.              :..||
plant   655 NEQYTWEVYDPCTVVTVGVFDNARVNENN--NSRDVRIGKVRIRLSTLETGRVYTHSYPLIVLHP 717

  Fly  3027 G----TGEHKVNVKVVAAN 3041
            .    |||..:.|::...|
plant   718 SGVKKTGELHLAVRLSCGN 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996
		C2B_Munc13	2160..2286	CDD:175993	42/136 (31%)
		DUF1041	2477..2584	CDD:283860	20/117 (17%)
		Membr_traf_MHD	2832..2992	CDD:287505	30/171 (18%)
		C2C_Munc13	3032..3152	CDD:176041	2/10 (20%)
AT1G04150	NP_171911.1	C2A_MCTP_PRT_plant	12..138	CDD:175989	47/165 (28%)
		C2B_MCTP_PRT_plant	280..398	CDD:176024	25/146 (17%)
		C2C_MCTP_PRT_plant	435..591	CDD:175986	32/176 (18%)
		C2D_MCTP_PRT_plant	603..729	CDD:176025	30/188 (16%)
		PRT_C	863..1012	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920