DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and AT5G17980

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_197299.1	Gene:	AT5G17980 / 831665	AraportID:	AT5G17980	Length:	1049	Species:	Arabidopsis thaliana

Alignment Length:	613	Identity:	131/613 - (21%)
Similarity:	218/613 - (35%)	Gaps:	197/613 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  2161 KIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNS------S 2219
            |:.:.|:.|:.|..||..|||.|||.:.....::||||:.::|||||||...|.....      :
plant     6 KLVVEVVDAKDLTPKDGHGTSSPYVVLDYYGQRRRTRTIVRDLNPVWNETLEFSLAKRPSHQLFT 70

  Fly  2220 DRIKVRVWDEDNDLKSKLRQKLTR---ESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 2281
            |.:::.::.:.|..:::....|.|   .||.|:||        ..|..::|.|||::..:.|.|.
plant    71 DVLELDMYHDKNFGQTRRNNFLGRIRLGSDQFVGQ--------GEEALIYYPLEKKSLFNLVQGE 127

  Fly  2282 IRLHI-------------------SVEIKGEEKVA---------------PYHVQYTC------- 2305
            |.|.:                   .||.|.||..|               |..|:.|.
plant   128 IGLRVYYADEKPPPLKPTVAPLETVVEEKTEETKAEGPDESKPPPETNDIPAEVKETVKPPQPPP 192

  Fly  2306 ------------------LHENLFHYLCEENTGMVKLPTQKGD--DAWKLYFDEIPEEIVDEFSM 2350
                              |.||       ...|..:.|..:.|  :|.....:|.|:...|
plant   193 EESSPAEGPKPDEEASPPLQEN-------ATVGGEEPPASESDKNEAEAKPVEEPPQNQPD---- 246

  Fly  2351 RYGIENIYQAMTHFHCLSA-----------KYLCPGVPAVMS---TLLANINAYYAHTTASSAVS 2401
              |.:.:.::.......||           :.:...:|...:   .|..:::...::|:..|.||
plant   247 --GEDIVLESEDTMSWASAPRSPLPEVIISRSVSGSIPETKNGPQPLRRSVSETASYTSEISDVS 309

  Fly  2402 ASDRFAASNFGKEKFVKLLDQLHN-SLRIDLSMYRNNFPAS-SPEKLMDLKSTV-----DLLTSI 2459
            ..:|   |.|      .|::::|. .:|:   :...:.|.| ||...:.|..|:     ...||.
plant   310 TIER---STF------DLVEKMHYVFIRV---VKARSLPTSGSPVTKISLSGTMIQSKPARKTSC 362

  Fly  2460 -----TF-FRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPD 2518
                 || |.....:|||.|.....|.|.....  .|.|||...|:::.....: ||.::..||.
plant   363 FEWDQTFAFLRDSPDLSSSPILEISVWDSSTGI--ETSQFLGGICFDVSEIPLR-DPPDSPLAPQ 424

  Fly  2519 DHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVL-----------NQFPQEL---NIGQLSA--- 2566
                       |::|         |...::.:.|           ..||...   ..|.::|
plant   425 -----------WYRL---------EGGGAHNSDLMLATWTGTQADESFPDAWKTDTAGNVTARAK 469

  Fly  2567 ----SSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVP--DYPA 2625
                |.:|:|.|     .:.|.:.....:.:|:....|::|....:.|::.   |.||.  ..|:
plant   470 VYMSSKLWYLRA-----TVIEAQDLLPPQLTAFKEASFQLKAQLGSQVQKT---KSAVTRNGAPS 526

  Fly  2626 W--------FEPFVMQWLNENDDVSLEY 2645
            |        .|||..|.:     .:|||
plant   527 WNEDLLFVAAEPFSDQLV-----FTLEY 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996
		C2B_Munc13	2160..2286	CDD:175993	42/133 (32%)
		DUF1041	2477..2584	CDD:283860	23/127 (18%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
AT5G17980	NP_197299.1	C2A_MCTP_PRT_plant	6..136	CDD:175989	42/137 (31%)
		C2B_MCTP_PRT_plant	324..446	CDD:176024	31/147 (21%)
		C2C_MCTP_PRT_plant	478..623	CDD:175986	19/85 (22%)
		C2D_MCTP_PRT_plant	635..764	CDD:176025
		PRT_C	893..1049	CDD:285560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920