DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and FTIP1

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_568175.2	Gene:	FTIP1 / 830576	AraportID:	AT5G06850	Length:	794	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	161/855 - (18%)
Similarity:	277/855 - (32%)	Gaps:	292/855 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2110 AMKDRMKQRE-----REKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKW--SAKIAIT-- 2165
            |.||..|.:|     ..|||:         .|...|.|..         |.:.|  |.:.|.|
plant     2 AAKDGAKSQEDYKLKDMKPEL---------GERWPHGGQR---------GGTGWIGSERAASTYD 48

  Fly  2166 -----------VICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSS 2219
                       |:.|:.|.....:...||||.|::...|.:|:...:..||.||:.|.|    |.
plant    49 LVEQMFYLYVRVVKAKDLPPNPVTSNCDPYVEVKIGNYKGKTKHFEKRTNPEWNQVFAF----SK 109

  Fly  2220 DRIK---VRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTL-------SGEMDVWYNLEKRTD 2274
            |:::   |.|:..|.::       :||  |:::|:.:.::|.:       |.....||.||.|..
plant   110 DKVQSSTVEVFVRDKEM-------VTR--DEYIGKVVFDMREVPTRVPPDSPLAPQWYRLEDRRG 165

  Fly  2275 KSAVSGAIRLHISVEIKGEEKVA-PYHVQYTCLHENLFHYLCEENTGMVKLPTQKGDDAWKLYFD 2338
            :|...|.:.:.:.:..:.:|... .:|...:.:.        .|....|:.........|.|..:
plant   166 ESKKRGEVMVAVWLGTQADEAFPDAWHSDASSVQ--------GEGVQSVRSKVYVSPKLWYLRVN 222

  Fly  2339 EIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPG---------------------------- 2375
            .|..:.|:........:...:.......|..| |||.
plant   223 VIEAQDVEPSDRSQPPQAFVKVQVGNQILKTK-LCPNKTTNPMWNEDLVFVAAEPFEEQFFLTVE 286

  Fly  2376 ---VPA---VMSTLLANINAY---YAHTTASSAVSASDRFAASNFG-----KEKFVKLLDQLHNS 2426
               .||   ||..|::.::.:   ..|....|.....::|   .||     |...:|...::|
plant   287 NKVTPAKDEVMGRLISPLSVFEKRLDHRAVHSKWYNLEKF---GFGALEGDKRHELKFSSRIH-- 346

  Fly  2427 LRIDL----------SMYRNNFPAS----------------------SPEKLMDLKSTVDLLTSI 2459
            ||:.|          ::|.::...:                      ||.|..|.|:|.|.....
plant   347 LRVCLEGGYHVMDESTLYISDVKPTARQLWKSPIGILEVGILSAQGLSPMKTKDGKATTDPYCVA 411

  Fly  2460 TFFRMKVQ-----ELSSPPRASTVVKDCVKACLRSTYQFLFENCY----ELYNREFQVDPNEAKR 2515
            .:.:..|:     :.|||........:....|...|.. :|:||:    |..|...:||....|
plant   412 KYGQKWVRTRTIIDSSSPKWNEQYTWEVYDPCTVITLG-VFDNCHLGGSEKSNSGAKVDSRIGK- 474

  Fly  2516 APDDHEPKLDSVDFWHKLIALIVSVIDEDK---NSYGTVLNQFPQELNIGQ---------LSASS 2568
                              :.:.:|.::.|:   :||..::.|......:|:         ||.:.
plant   475 ------------------VRIRLSTLEADRIYTHSYPLLVLQTKGLKKMGEVQLAVRFTCLSLAH 521

  Fly  2569 MWHLFAVDMKYALEEHEQHRLCKSSAYMNLH-FRVKWLYS-----------NYVKEVPPYKGAVP 2621
            |.:|:.            |.|.....|  || |.|..|.|           ...:..||.:
plant   522 MIYLYG------------HPLLPKMHY--LHPFTVNQLDSLRYQAMSIVAARLSRAEPPLR---- 568

  Fly  2622 DYPAWFEPFVMQWLNENDDVSLEYL-----H-GAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQ 2680
                          .||    :||:     | .:.:|.|.:.|:           :|.||..|.
plant   569 --------------KEN----VEYMLDVDSHMWSMRRSKANFFR-----------IVSVFAGLI- 603

  Fly  2681 CFDVVSKLECPDPEIWKRYMRRFA-KTIVKVLIAYADIV------------------KLEFPEHM 2726
               .:||. ..|...||..:.... ..:..:||.|.:::                  :...|.||
plant   604 ---AMSKW-LGDVCYWKNPLTTILFHVLFFILICYPELILPTTFLYMFLIGLWNFRFRPRHPAHM 664

  Fly  2727 KDERIACILMNNIQQLRVQLEKMFESMGGD--KLEEDAANILKELQQNLNSALDDLASQ---FAI 2786
             |.:::.....:..:|..:.:....|.|.|  |:..|.   |:.:...:...:.|:|:|   |..
plant   665 -DTKVSWAEAASPDELDEEFDTFPTSKGQDVVKMRYDR---LRSVAGRIQMVVGDIATQGERFQA 725

  Fly  2787 SL---EPRIT 2793
            .|   :||.|
plant   726 LLSWRDPRAT 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996
		C2B_Munc13	2160..2286	CDD:175993	36/148 (24%)
		DUF1041	2477..2584	CDD:283860	20/122 (16%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
FTIP1	NP_568175.2	C2B_MCTP_PRT_plant	55..181	CDD:176024	34/138 (25%)
		C2C_MCTP_PRT_plant	218..370	CDD:175986	25/157 (16%)
		C2D_MCTP_PRT_plant	382..511	CDD:176025	27/148 (18%)
		PRT_C	639..794	CDD:337028	19/101 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920