DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and AT4G00700

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001328213.1	Gene:	AT4G00700 / 828031	AraportID:	AT4G00700	Length:	1006	Species:	Arabidopsis thaliana

Alignment Length:	820	Identity:	171/820 - (20%)
Similarity:	261/820 - (31%)	Gaps:	257/820 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1942 RDKNGGGPGEVGLR--------TNGHPGDNP-----FYSNIDSMPDIRPRRKSIPLVS---ELVL 1990
            |||:......|.|:        |..|...||     ||..:.....:..|.....:.|   |...
plant    19 RDKHNSCSPFVELKFDNQIFRATTKHNDPNPVWHECFYFVVSDPSVLSTRTLEAHVYSYQNEFDA 83

  Fly  1991 KTMAATKRNAGLTSAVPR---ATLNDEDLKMHVYKKA-----LQALIYPISSTTPHNFLLWTATS 2047
            |......|..| ||.|||   |..|....|..|:.:|     |:..|....|.||        :.
plant    84 KPFLGKVRVNG-TSFVPRSEAAPFNYPLEKRSVFSRARGELCLRVFITDDPSVTP--------SV 139

  Fly  2048 PTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSS-KHGAEDKANSI---- 2107
            ||...|.........|:            |..|.|:.||......|:.. |.......||.
plant   140 PTPVPESPQAYSPSPRK------------EHVKSLITADASMATDERRELKPKTRTFHNSAPLVK 192

  Fly  2108 -------------ITAMKDRMKQREREKPEIFELIRAVFSVEEKSH-AGHMKAVKQSVLDGTSKW 2158
                         ...|..|:.|.....|.:.:| ...|||:|.|. .|..:.|...|:.||.:.
plant   193 QQPMMNYGIHEMRAAPMPPRVVQVNGPGPSLHQL-PPDFSVKETSPLLGGGRIVGGRVVRGTERP 256

  Fly  2159 SAK----------IAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHF 2213
            ::.          :.:.|:.|:.|..||.:|:.||||.|::...|..|....:..:|.||:.|.|
plant   257 TSGTYDLVEEMKFLYVRVVKARDLPNKDLTGSLDPYVVVKIGNFKGVTTHFNKNTDPEWNQVFAF 321

  Fly  2214 ECHN-SSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEM-------DVWYNLE 2270
            ...| .|:.::|.|.|:|..|            |||:|....::|.:...:       ..||.||
plant   322 AKDNLQSNFLEVMVKDKDILL------------DDFVGIVKFDLREVQSRVPPDSPLAPQWYRLE 374

  Fly  2271 KRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCEENTGMVKLPTQKGDDAWKL 2335
            .:                  :||:|                :|       .:.|....|..|.:.
plant   375 NK------------------RGEKK----------------NY-------EIMLAVWSGTQADEA 398

  Fly  2336 YFD-EIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSA 2399
            :.| ...:.:||..|     .||..|    :..|..|..|.:..:...:|          .|...
plant   399 FGDATFSDSLVDSDS-----SNIISA----NLRSKVYHSPRLWYLRVQIL----------EAQDV 444

  Fly  2400 VSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFP-ASSPEKLMDLKSTVDLLTSITF-- 2461
            :..||:...    .|.||:        :::...|.|..|| .|:..|..|         ..||
plant   445 IIVSDKSRV----PEVFVR--------VKVGNQMLRTKFPQRSNNPKWGD---------EFTFVV 488

  Fly  2462 -------FRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDD 2519
                   ..:.|::.::|.|...|.|..:                 |.|               |
plant   489 AEPFEDNLVLSVEDHTAPNRDEPVGKAVI-----------------LMN---------------D 521

  Fly  2520 HEPKLDSVDF---WHKLIALIVSVIDEDKNS---------YGTVL----NQFPQEL-NIGQLSAS 2567
            .|.::|...|   |..|...|...:|.||..         |..||    :.|.:.: |...|..|
plant   522 IEKRIDDKPFHDRWVHLEDSISDAMDVDKAKKVKFATRLRYKAVLDGGYHVFDESMYNSSDLRPS 586

  Fly  2568 S--MWH---------LFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYV--KEVPPYKGA 2619
            |  :|.         :...::.::::..|...  .|..|:...:..||:.|..|  ...|.|.
plant   587 SRKLWKPAIGVLELGILNANVFHSMKTREGKG--TSDTYVVAKYGHKWVRSRTVINSMNPKYN-- 647

  Fly  2620 VPDYPAW--FEPFVMQWLNENDDVSLEYLHGAFKRDKKDG 2657
              :...|  |:|..:..:...|:.......|..|||:..|
plant   648 --EQYTWEVFDPATVLTICVFDNAHFAAGDGGNKRDQPIG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	8/48 (17%)
		C2B_Munc13	2160..2286	CDD:175993	34/143 (24%)
		DUF1041	2477..2584	CDD:283860	23/134 (17%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
AT4G00700	NP_001328213.1	C2A_MCTP_PRT_plant	5..131	CDD:175989	29/112 (26%)
		C2B_MCTP_PRT_plant	269..393	CDD:176024	39/176 (22%)
		C2C_MCTP_PRT_plant	433..585	CDD:175986	39/214 (18%)
		C2D_MCTP_PRT_plant	597..723	CDD:176025	18/95 (19%)
		PRT_C	851..1006	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920