DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-13 and AT3G57880

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001327704.1	Gene:	AT3G57880 / 824957	AraportID:	AT3G57880	Length:	773	Species:	Arabidopsis thaliana

Alignment Length:	484	Identity:	108/484 - (22%)
Similarity:	177/484 - (36%)	Gaps:	119/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  2078 KCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVF----SVEEK 2138
            |.||.:..|.:.|.....::.......:|.:.....|::.|:.:|.: .||:.||:    :.|..
plant   107 KDKDFVKDDLIGRVVFDLNEVPKRVPPDSPLAPQWYRLEDRKGDKVK-GELMLAVWFGTQADEAF 170

  Fly  2139 SHAGHMKAVKQSVLDGTSKWSAKI---------AITVICAQGLIAKDKSGTSDPYVTVQVSKVKK 2194
            ..|.|..|...|..|..:...:|:         .:.||.||.||..||....:.||...|.....
plant   171 PEAWHSDAATVSGTDALANIRSKVYLSPKLWYLRVNVIEAQDLIPTDKQRYPEVYVKAIVGNQAL 235

  Fly  2195 RTR-TMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRT 2258
            ||| :..:.:||:|||...|        :....::|  .|...:..::....|:.||:..|.::.
plant   236 RTRVSQSRTINPMWNEDLMF--------VAAEPFEE--PLILSVEDRVAPNKDEVLGRCAIPLQY 290

  Fly  2259 LSGEMD------VWYNLEKRT----DKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHY 2313
            |....|      .||||||..    :|.....|.|:|:.:.::|     .|||    |.|:. ||
plant   291 LDRRFDHKPVNSRWYNLEKHIMVDGEKKETKFASRIHMRICLEG-----GYHV----LDEST-HY 345

  Fly  2314 ----------LCEEN-----------TGMVKLPTQKG---DDAWKL--YFDE--IPEEIVDEFSM 2350
                      |.:.|           ||::.:.|:.|   .||:.:  |..:  ....|:|.|:.
plant   346 SSDLRPTAKQLWKPNIGVLELGILNATGLMPMKTKDGRGTTDAYCVAKYGQKWIRTRTIIDSFTP 410

  Fly  2351 RYGIENIYQAM-------------THFH----CLSAKYLCPG-VPAVMSTLLANINAYYAHTTAS 2397
            |:..:..::..             .|.|    ...||....| |...:|||  ..:..|.|:...
plant   411 RWNEQYTWEVFDPCTVVTVGVFDNCHLHGGEKIGGAKDSRIGKVRIRLSTL--ETDRVYTHSYPL 473

  Fly  2398 SAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLS-----MYRNNFPA------SSPEKLMDLKS 2451
            ..:..:.            ||.:.::|.::|...|     ||..:.|.      ..|..:..|.:
plant   474 LVLHPNG------------VKKMGEIHLAVRFTCSSLLNMMYMYSQPLLPKMHYIHPLTVSQLDN 526

  Fly  2452 TVDLLTSITFFRMKVQELSSPPRASTVVK 2480
            .....|.|...|:...|   ||....||:
plant   527 LRHQATQIVSMRLTRAE---PPLRKEVVE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	3/8 (38%)
		C2B_Munc13	2160..2286	CDD:175993	38/145 (26%)
		DUF1041	2477..2584	CDD:283860	2/4 (50%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
AT3G57880	NP_001327704.1	C2B_MCTP_PRT_plant	40..164	CDD:176024	13/57 (23%)
		C2C_MCTP_PRT_plant	202..351	CDD:175986	46/168 (27%)
		C2D_MCTP_PRT_plant	363..490	CDD:176025	25/140 (18%)
		PRT_C	618..773	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920