DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and MCTP1

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_078993.4	Gene:	MCTP1 / 79772	HGNCID:	26183	Length:	999	Species:	Homo sapiens

Alignment Length:	720	Identity:	138/720 - (19%)
Similarity:	244/720 - (33%)	Gaps:	245/720 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2101 EDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEE--------------------------KS 2139
            |.::..:...|:...|:..:|..| .|::.:.|||:.                          |:
Human   385 EGESRDVTMLMRKSWKRSSKELSE-NEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKN 448

  Fly  2140 HAGHMKAVKQSVLDGTSK-WSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQEL 2203
            .....::::.|.|...|. |...::||:|..:.|.|.|.:|.|||||..::...|.:::.||:.|
Human   449 VQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTL 513

  Fly  2204 NPVWNEKFHFECHNSSDR---IKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDV 2265
            ||.|.|:|.|  |...:|   |.:..||:|           ..:.|||:|:..:::..||.|..
Human   514 NPQWREQFDF--HLYEERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLSALSREQT- 564

  Fly  2266 WYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHV--------------QYTCLHENLFHYLCE 2316
             :.||.:.::.  .|.:.|.:::.......::...|              :|:.|  .:||.|.:
Human   565 -HKLELQLEEG--EGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPL--RIFHNLKD 624

  Fly  2317 ENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMS 2381
            .....||:...:|..|..:.....|..:|:..:.|.....:|           |.|.|....|.:
Human   625 VGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVY-----------KNLNPEWNKVFT 678

  Fly  2382 TLLANINAYYAHTTASSAVSASDRFAASNF-------------GKEKFVKL-------------- 2419
            ..:.:|     |:.....|...||..:::|             |::|...|
Human   679 FNIKDI-----HSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIY 738

  Fly  2420 --LDQLHNSLRIDLSMYRNNFPASSP--------------EKLMDLKSTVDLLTSITFFRMKVQE 2468
              :|.:.|:::..|   |...|....              ...:.:|..|.:|.:..::.....:
Human   739 LEIDVIFNAVKASL---RTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFD 800

  Fly  2469 LSSPPRASTVVKDCVKACLRSTYQFLFE--NCYELY----------------------NREFQV- 2508
            ..||||:           |.:...|||.  | :|||                      ||:...
Human   801 WDSPPRS-----------LAAFVLFLFVVWN-FELYMIPLVLLLLLTWNYFLIISGKDNRQRDTV 853

  Fly  2509 --DPNEAKRAPDDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWH 2571
              |..|.:...||.:.|                  |.:|..:
Human   854 VEDMLEDEEEEDDKDDK------------------DSEKKGF----------------------- 877

  Fly  2572 LFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLN 2636
               ::..||::|     :|.|             ..|.:.||..:...:.:...|..|| :.||.
Human   878 ---INKIYAIQE-----VCVS-------------VQNILDEVASFGERIKNTFNWTVPF-LSWLA 920

  Fly  2637 END---------DVSLEYL---HGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLE 2689
            ...         .:.|.|:   .|..|..||    ..|.:|:.:|.::|..:::.....||...|
Human   921 IVALCVFTAILYCIPLRYIVLVWGINKFTKK----LRSPYAIDNNELLDFLSRVPSDVQVVQYQE 981

  Fly  2690 C-PDP 2693
            . |||
Human   982 LKPDP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996
		C2B_Munc13	2160..2286	CDD:175993	39/128 (30%)
		DUF1041	2477..2584	CDD:283860	19/133 (14%)
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
MCTP1	NP_078993.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..241
		C2A_MCTP_PRT	262..383	CDD:176007
		C2B_MCTP_PRT	471..586	CDD:176022	39/131 (30%)
		C2C_MCTP_PRT	626..744	CDD:176023	22/133 (17%)
		PRT_C	<887..972	CDD:285560	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920