DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-13 and unc13a

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:XP_009294560.1 Gene:unc13a / 568618 ZFINID:ZDB-GENE-140722-1 Length:1818 Species:Danio rerio


Alignment Length:1993 Identity:984/1993 - (49%)
Similarity:1261/1993 - (63%) Gaps:311/1993 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1310 GLKKKTISSKMSGLMQKAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGNDNSSISTREILLNQSI 1374
            |:||    :|:.|..:|..||                       ||....|...:|        |
Zfish     7 GVKK----AKLDGPQEKFNTY-----------------------VSLKVQNVKSTT--------I 36

  Fly  1375 EVEDEQ----EDFNYK-NRCDSKSVLGGSIEKLNGNL-----TNNLFPIVGDLKKIQSPLP---L 1426
            .|...|    :||.:: ||.|    ||.::|..|..|     ...|:..:..:::.....|   |
Zfish    37 AVRGSQPCWEQDFMFEINRLD----LGLTVEVWNKGLIWDTMVGTLWIPLSSIRQSNEEGPGQWL 97

  Fly  1427 AVLTEIPSYKDEYSNKSDSIKNSPIEMPKILLETACNQELNLAHSDDDVD------KNILANSAK 1485
            .:..::...::|.....|.      ...::||:|  ..||.|...:::..      :.:.|...:
Zfish    98 TLDAQVIMAENEICGTKDP------TFHRVLLDT--RFELPLDIPEEEARYWAKKLEQLNAMRDQ 154

  Fly  1486 DYVNAPTFSILKTVEDASEPTMTPLHTTTTTNSSLNVTSALWVTQQCLDLPNYPGWGSREDDDNR 1550
            ||    ||.     |:...|...|                  .||.|    |:..||.:::||..
Zfish   155 DY----TFQ-----EEHERPLPMP------------------STQCC----NWSLWGDQQNDDPD 188

  Fly  1551 SQHSARTLSSSRRQSTEDSIDTDDEYFY-----------YELRQLE-----------EQEKQRAH 1593
            |....|  .|..|..|.:||...   ||           |.:||::           :.:.||| 
Zfish   189 SAVDDR--DSDYRSETSNSIPPP---FYTTSQPNASMHQYPIRQMQHGSRYNEMHDYDYDNQRA- 247

  Fly  1594 NSAIPSCERQNDNDVLFSQIGQLLQNDVNGGDGFRHSNGCN---------DGEDAIIFSPSESVK 1649
                   .|:.|:          |.:..||......::|.:         |...::..||:.|.:
Zfish   248 -------IRRYDS----------LDSATNGRSDLDSASGSSRRTSRQYSLDSRHSLSDSPTGSSR 295

  Fly  1650 LRMSEVFKELKSVVSLNPSVNNDATFEGVPIVKPTYEKLETVSDLHSA---------WQDVNGDL 1705
            ...|.......|.:|......:..:|.|   ....|::.::....||:         | |.:...
Zfish   296 YASSGELSRGSSQLSEEFGPEDGESFRG---SGEFYDENDSYHSCHSSVSYGKESPGW-DPDEPQ 356

  Fly  1706 QIAASDIDSNEDLVGNKGRETPTYNKQRKLRRLKKKTRDRKINISKNATSSSSSCHSENECNTPL 1770
            .:.:.|.:.|:|    .|.|...|:::.::                         :.::|...|.
Zfish   357 GVYSDDGEYNKD----GGEEGALYDEEGEI-------------------------YEQDEGEYPY 392

  Fly  1771 GQCTQKSVAEKDTNDISNKSEASSETSGPDTPAELSDVDISETENGLRADDGQNIDNMRGNSGSL 1835
            .:..:..|.|:|.:........|.|...|.||...|      |...|..|               
Zfish   393 EEEEEGMVYEEDEDLYPLDGTLSEEQEPPYTPTPTS------TAPTLAPD--------------- 436

  Fly  1836 LKVNRKYLLQFDVDHSLINQPLETSQYNTHMLENITSASIPSQNRQIDSK----TLMSQSSHADG 1896
            ...:|..|   :...|:..|....||.....:|....:..|.|...:.:|    |...|.|..:.
Zfish   437 ALTSRPPL---EKQASMHQQQPPQSQIPFQPMEPKRESPPPQQTHDVFAKVPRTTTPPQISDTEP 498

  Fly  1897 SQA---VGNETAVG---LSSSKWKL-LKTLKERK-----------------IEEKNNQDKIKEDE 1937
            .:.   .||..|..   ||:|..:: .|..:|:|                 |..|.|..::....
Zfish   499 EKVPTPPGNGPAYAEDLLSTSTTEIPPKAEQEKKEALPESISKQEPPVDPAIRAKANWLRLFNRV 563

  Fly  1938 MIKDRDKNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGL 2002
            .::.::..|..||...|.....|| ...|| ||||||:| :||:||||.:|.: ::....|.||:
Zfish   564 RLQLQEARGETPGLASLFLQAGPG-GALYS-IDSMPDLR-KRKAIPLVRDLAM-SLVQNSRKAGI 624

  Fly  2003 TSAVPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVR 2067
            |||:..:|||:|:||.|||||.|||||||||.||||||.:||||:||||||||||||||||||:|
Zfish   625 TSAMASSTLNNEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 689

  Fly  2068 CTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAV 2132
            ||||||||||||:||||||||||||||||||||||:..:||..:|||||.|||.||||||||:.|
Zfish   690 CTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQDV 754

  Fly  2133 FSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTR 2197
            |:|.:.:|...||.:|||||||||||||||:|||:|||||.||||:|:|||||||||.|.||||:
Zfish   755 FAVIKATHVAQMKQIKQSVLDGTSKWSAKISITVLCAQGLQAKDKTGSSDPYVTVQVGKTKKRTK 819

  Fly  2198 TMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGE 2262
            |:...|||||:|.|:||||||||||||||||||:|:||:::||..||||||||||||||||||||
Zfish   820 TIYGNLNPVWDESFNFECHNSSDRIKVRVWDEDDDIKSRVKQKFKRESDDFLGQTIIEVRTLSGE 884

  Fly  2263 MDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCE-ENTGMVKLPT 2326
            |||||||:|||||||||||||:||||||||||.|||||||||||||||||||.: :|.|:||:|.
Zfish   885 MDVWYNLDKRTDKSAVSGAIRMHISVEIKGEETVAPYHVQYTCLHENLFHYLTDIQNNGVVKIPD 949

  Fly  2327 QKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYY 2391
            .|||||||:||:|.|:||||||:||||:|:||||||||.|||:||:|||||||||||||||||||
Zfish   950 AKGDDAWKVYFEETPQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYY 1014

  Fly  2392 AHTT-ASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDL 2455
            |||| |::.|||||||||||||||:|||||||||||||||||||||||||||||:|.||||||||
Zfish  1015 AHTTQATNNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDL 1079

  Fly  2456 LTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDH 2520
            ||||||||||||||.||||||.||||||||||.|||:::|.||:|||:||:|.|||:....|.:.
Zfish  1080 LTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPNKKGEVPPEE 1144

  Fly  2521 E-PKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEH 2584
            : |.:.::|||.|||.||||:|:||||||...|||||||||:|::||..||:|||.|||||:|||
Zfish  1145 QGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEH 1209

  Fly  2585 EQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGA 2649
            |::|||||:.||||||:|||||:.|.|::|.:|..||:||.||||||:|||:||::||.::||||
Zfish  1210 EKNRLCKSADYMNLHFKVKWLYNEYCKDLPFFKSRVPEYPTWFEPFVIQWLDENEEVSRDFLHGA 1274

  Fly  2650 FKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAY 2714
            .:||||||:|::|||||||.||||||:||.|.|:::.|||||||:|...||:||||||..||::|
Zfish  1275 LERDKKDGYQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMKRFAKTISNVLLSY 1339

  Fly  2715 ADIVKLEFPEHMKDERI--------ACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQ 2771
            |||:..:||.|...|::        .|||:|||||||||||||||:|||..|..:|::||||||.
Zfish  1340 ADIISRDFPNHCTKEKVNAKDGAVKPCILINNIQQLRVQLEKMFEAMGGKDLNVEASDILKELQL 1404

  Fly  2772 NLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQR-NAVAVEADEVLRP 2835
            .||:.|||||..||.|.:|.|.::|:::||:|..:||      .||:.|.. ::||.:||.||:|
Zfish  1405 KLNNVLDDLARIFATSFQPNIEENVKQMGDILSQVKG------TGNVPASACSSVAQDADNVLQP 1463

  Fly  2836 LMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPMTDKTMMFK-----HLTDNAK 2895
            :||.||.:|||:|:.||||||||:||||||:||..:||||||||:||:||:.:     | :|..:
Zfish  1464 IMDFLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGRVKLACH-SDGTQ 1527

  Fly  2896 NLASNAKIEDMGRL--FKSHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFH 2958
            .:.:.||  ::|:|  .|.||.                :|..|.||||||||:::||||||||||
Zfish  1528 LIFNAAK--ELGQLSKLKEHMV----------------REEAKALSPKQCAVIELALDTIKQYFH 1574

  Fly  2959 AGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISS---QVH---EVDLENSE------- 3010
            |||.|||||||||||:||||.||||||||.||.|||||:.|   |||   .|....||       
Zfish  1575 AGGVGLKKTFLEKSPDLQSLHYALSLYTQATDKLIKTFVQSQNTQVHGGKGVRFTQSEDVYPEKG 1639

  Fly  3011 ----ESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKRK 3071
                ::|||:|:.:::|:||.||||||.|||||||||:|| .||:|||||::.:|||||.:||||
Zfish  1640 TGVDDAVGEVSIHVEIFTHPNTGEHKVTVKVVAANDLRWQ-TSGIFRPFVEVYIIGPHLSDKKRK 1703

  Fly  3072 FATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVIPLKDISEKGSV 3136
            :|||||:|:|:|||||:|:||:.||...:.:||.:|||||||||:||.||:||:.|||::.:|||
Zfish  1704 YATKSKNNSWAPKYNETFTFTLSNEVGPECYELQVCVKDYCFAREDRTVGMAVLQLKDVAPRGSV 1768

  Fly  3137 ACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIR 3179
            ||||||.:||.|||||.|:||||||||||:||||||||||:.|
Zfish  1769 ACWLPLGKRIHMDETGLTVLRILSQRNNDDVAKEFVKLKSDQR 1811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 43/48 (90%)
C2B_Munc13 2160..2286 CDD:175993 101/125 (81%)
DUF1041 2477..2584 CDD:283860 67/107 (63%)
Membr_traf_MHD 2832..2992 CDD:287505 96/166 (58%)
C2C_Munc13 3032..3152 CDD:176041 80/119 (67%)
unc13aXP_009294560.1 C2A_Munc13 1..127 CDD:176040 33/166 (20%)
C1 660..709 CDD:237996 43/48 (90%)
C2B_Munc13 782..908 CDD:175993 101/125 (81%)
DUF1041 1101..1209 CDD:283860 67/107 (63%)
mycoplas_twoTM 1321..>1496 CDD:275320 97/180 (54%)
Membr_traf_MHD 1460..1608 CDD:287505 96/166 (58%)
C2C_Munc13 1665..1784 CDD:176041 80/119 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 365 1.000 Domainoid score I884
eggNOG 1 0.900 - - E1_KOG1011
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H11279
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001626
OrthoInspector 1 1.000 - - otm26418
orthoMCL 1 0.900 - - OOG6_103034
Panther 1 1.100 - - O PTHR10480
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1191
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
109.770

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