DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-13 and mctp2b

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:XP_021333398.1 Gene:mctp2b / 562526 ZFINID:ZDB-GENE-050506-136 Length:855 Species:Danio rerio


Alignment Length:1081 Identity:206/1081 - (19%)
Similarity:355/1081 - (32%) Gaps:398/1081 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1916 LKTLKERKI---------EEKNNQDKIKEDEMIKDRDKNGGGPGEVG--LRTNGHPGDNPFYSNI 1969
            ||.::.:::         ||:.||.....|        :|..|..:.  :..|||.|     ::.
Zfish    15 LKLIRSKRVGSDKHPSILEEQENQQINLSD--------SGKLPRSLSSPVHQNGHSG-----TSC 66

  Fly  1970 DSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAVPRA--TLNDEDLKMHVYKKALQALIYPI 2032
            :..|       :.||...|        ::..|||.::|..  :|.|.|:.   ||:         
Zfish    67 NGSP-------TSPLSVNL--------RKRGGLTGSMPVLVDSLQDSDVP---YKE--------- 104

  Fly  2033 SSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSK 2097
                                          |.|.||::.....|.:       |.:......:|:
Zfish   105 ------------------------------RNGSRCSDDMDVRHMR-------DSIYSTESVTSE 132

  Fly  2098 HGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKI 2162
            ....||.:|      |....::.|:..|.::            :..|..|.::     .:.|.:.
Zfish   133 KSNYDKNDS------DSGSIQDNEQNGILDI------------SAEMPGVCEN-----QRESQRT 174

  Fly  2163 AITVIC---AQGLIAKDKSGTSDPYVTVQV-SKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIK 2223
            .:..||   .:.|:.:|:.|||||||.|:: .|:..:::.:.:.|||||||.|.|...:....:.
Zfish   175 YLLTICLKEGRNLVIRDRCGTSDPYVKVKLDGKMVYKSKVVLKNLNPVWNESFTFPIRSLEQTVF 239

  Fly  2224 VRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRT-------DKSAVS-- 2279
            ::|:|.|          ||  ||||:|...:.:..|        .|||.|       |.:::.  
Zfish   240 IKVFDRD----------LT--SDDFMGSCSVGLDKL--------ELEKTTEMVLPLDDPNSLEED 284

  Fly  2280 -GAIRLHISVEIKG----EEKVAPYHVQYTCLHENLFHYLCE----------------------- 2316
             |.|.:.|.|.::|    ::|.|..:::....:.|.:..:.|                       
Zfish   285 MGFIAIDICVSMRGGKNKKQKWAQRNIRSLMGNSNEYKRMSESVNKSQLWIGLYTITLVDGRDLP 349

  Fly  2317 -ENTGMVKLPTQKGDD-------------AWKLYFD--EIPE-------EIVDEFSMR----YGI 2354
             :..|.:.:..:.||.             .|:..||  :.|:       |:|.:...:    ||:
Zfish   350 KDGQGDLFVRFKLGDQKFKSKSRSKKVITEWRERFDFYQFPDASSLLEIEVVLKDGRKSEESYGL 414

  Fly  2355 ENI------YQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGK 2413
            ..|      ....|.|.|    .|.||...|:         :.....|.:..|.||....     
Zfish   415 SEINLSELPLNESTLFSC----DLEPGRGKVV---------FLITPKACTGASISDLITP----- 461

  Fly  2414 EKFVKLLDQLHNSLRIDLSMYRNNFPASSPEK------LMDLKSTVDLLTSITFFRMKVQELSSP 2472
                                     |...||:      ...||:||..|..:.|.::||.:.:..
Zfish   462 -------------------------PLEDPEEKENILAKYSLKNTVRDLRDVGFLQVKVIKATDL 501

  Fly  2473 PRASTVVKD---CVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAP--DDHEPKLDSVDFWHK 2532
            ..|....|.   ||.....|..|  ....|:..|.|:    |:....|  |.||           
Zfish   502 ISADLNGKSDPFCVLELGNSRLQ--THTIYKTLNPEW----NKVFTFPVKDIHE----------- 549

  Fly  2533 LIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMN 2597
              .|.|:|.|||    |.....|..::.|..:||........     .|.:.....:.|.:..:.
Zfish   550 --VLEVTVFDED----GDKAPDFLGKVAIPLVSACQGQQFIC-----PLRKENLTSMSKGAVILE 603

  Fly  2598 LHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSS 2662
            |..    |::       |.|.::    ..|.|...::|.:|...|.:.|.....|.:......|.
Zfish   604 LEI----LFN-------PIKASI----ITFTPREQKFLEDNPKFSKKILSRNIGRVRNLFRAVSY 653

  Fly  2663 EHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIA--YADIVKLEF--- 2722
            .|..           :|.||            .|:. :||.....:..|:|  |.:...|..   
Zfish   654 SHQF-----------ITSCF------------TWES-VRRSITAFLFFLLAVWYFEFYMLPLFLV 694

  Fly  2723 ------------------PEHM----------KDERIACIL--MNNIQQLRVQLEKMFESMGGDK 2757
                              ||:|          ||.....::  ::.:|::.|.::.:.       
Zfish   695 LLISWNYLQIATERVTRDPENMEICDDDDDDEKDSEKKGLMEKIHMVQEIVVTVQNLL------- 752

  Fly  2758 LEEDAANILKELQQNLNSALDDLASQFAISLEPRIT-----QSVRELGDMLLSIKGGSGTLAAGN 2817
              |:.|::.:.::...|.::..| |:.|:.:....|     .|||.: .:|..|...:..|    
Zfish   753 --EEIASLGERIKNTFNWSVPFL-SKLALMIFIMATVITYFVSVRYI-VLLYGIHKFTKKL---- 809

  Fly  2818 LAAQRNAVAVEADEVLRPLMDLL-----DGSLTLYAQ--SC 2851
                ||..|:|.:|    |:|.|     |..:|.|.:  ||
Zfish   810 ----RNPYAIENNE----LLDFLSRVPSDIQMTQYTEMSSC 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 5/48 (10%)
C2B_Munc13 2160..2286 CDD:175993 40/139 (29%)
DUF1041 2477..2584 CDD:283860 25/111 (23%)
Membr_traf_MHD 2832..2992 CDD:287505 8/27 (30%)
C2C_Munc13 3032..3152 CDD:176041
mctp2bXP_021333398.1 C2A_MCTP_PRT 176..296 CDD:176007 42/139 (30%)
C2B_MCTP_PRT 337..449 CDD:176022 19/124 (15%)
C2C_MCTP_PRT 489..607 CDD:176023 31/149 (21%)
PRT_C <748..829 CDD:285560 21/103 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D234298at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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