Protein Alignment unc-13 and mctp2a

DIOPT Version :9

• Sequence 1: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Sequence 2: XP_690870.6
• Gene: mctp2a / 562393
• ZFINID: ZDB-GENE-040724-63
• Length: 927
• Species: Danio rerio
• Alignment Length: 1016
• Identity: 181/1016 - (17%)
• Similarity: 329/1016 - (32%)
• Gaps: 343/1016 - (33%)

  Fly  1627 FRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELKSVVSLNPSVNNDATFEGVPIVKPTYEKLETV 1691
            |.:::|..|.:|    :.||:..:..||.|.........:|:.:..:.....|:...|.::...
Zfish    67 FDNTDGLGDIDD----TASETSSVAFSERFSVADVPYVCSPAPSERSAPVDFPVSAETDKRQRA- 126

  Fly  1692 SDLHSAWQDVNGDLQIAASDIDSNEDLVGNKGRETPTYNKQRKLRRLKKKTRDRKINISKNATSS 1756
                :.|...:.|.....:...:...:........||.:..:.:..|.:......::||    |.
Zfish   127 ----TTWYFEDSDSVTGVTPSSAELQMTAGHAERRPTESSDKLVAALGRARALDDMSIS----SE 183

  Fly  1757 SSSCHSENECNTPLGQCTQKSV----AEKDTNDISNKSEASSETSGPDTPAELSDVDISETENGL 1817
            ..:.|:|:|.::||......|.    ...:|:|..:.||.....||..|.        |::..||
Zfish   184 EKAWHTEHEPSSPLSMFVVGSAEYLDTPNETSDFDDLSEHERNISGGLTE--------SQSAAGL 240

  Fly  1818 R---------ADDGQNIDNMRGNSGS-----LLKVNRKYLLQFDVDHSLIN-------------- 1854
            :         ..:|:|: .:|..||:     ..|::.|::.:..|.:..:|
Zfish   241 QKLQYLLTINLKEGRNL-VVRDRSGTSDPFVKFKLDGKHIYKSKVVNKNLNPTWNESFSLPVRDL 304

  Fly  1855 -QPLETSQYNTHMLEN--ITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAVGL-------- 1908
             |.|....|:..:..|  :.|:|.|....::|...||:.|.....|:    |:.:|:
Zfish   305 DQTLHLKVYDRDLRSNDFMGSSSFPLSKLELDRMVLMTLSLEDPNSE----ESDMGVIIIEACLS 365

  Fly  1909 ------SSSKWKLLKTLKERKIEEKNNQDKIKEDE-----------------MIKDRDKNGGGPG 1950
                  ..:||.|      |:....|....|.:.:                 :::.:|....|.|
Zfish   366 IREEPAKRNKWLL------RRKGSFNKGQPISQAQFGRFTKSQVWSGVYTVILVEGQDMPDCGQG 424

  Fly  1951 EVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAVPRATLNDED 2015
            :|.:|..              :.|.|.|.||:.:                   .|.|:..   |.
Zfish   425 DVYVRFR--------------LGDQRVRSKSLCI-------------------KANPQWR---ES 453

  Fly  2016 LKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCK 2080
            ...:.::.|.:.|:..:                                   |.:.|.| .|:|.
Zfish   454 FDFNQFQDAQENLVVEV-----------------------------------CCKRGRK-SEECW 482

  Fly  2081 DLLNADCLQRAAEKSSKHGAE-----DKANSIIT------AMKDRMKQREREKPEIFELIRAVFS 2134
            .:|:.|..:....:...:..|     .|...::|      |....::....:.|..||.:|..:.
Zfish   483 GVLDIDLSRLPVNQRQLYTYELDPQKGKLRFLVTLTPCSGASISDIQSAPLDNPNTFEKMREQYR 547

  Fly  2135 VEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTM 2199
                         ..::| |..|....:.:.:|.|..|.:.|.||.|||:.|:::...|.:|.|:
Zfish   548 -------------PMNIL-GDFKNVGFLQVKLIRATDLPSTDISGKSDPFCTLELGNSKLQTHTI 598

  Fly  2200 PQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMD 2264
            .:.|||.|.....|...:..|.:.:.|:.||.|           ::.||||:..|.:.|:|....
Zfish   599 CKTLNPEWRTALTFPIRDIHDVLVLTVYHEDGD-----------KAPDFLGKVAIPLLTISNGQQ 652

  Fly  2265 VWYNLEKRTDKSAVSGAIRLHISV---EIK-GEEKVAP--------------------------- 2298
            :...|:......|..|:|.|.:.|   .|| |.:...|
Zfish   653 ITRMLKTNNLSRANKGSITLELKVLYNPIKAGIKTFQPKETMFAEDNPKFNKKLLARNIYRVRKI 717

  Fly  2299 -----YHVQYTCLHENLFHYLCEENTGMVKLPTQKGDDA----------WKLYFDEIPEEIV--- 2345
                 |.:||.   ::.||:   ||       ||:...|          |:|:.  :|..::
Zfish   718 SMAILYTLQYI---KSCFHW---EN-------TQRSITAFLIFVVAVWLWELFM--LPLFLLLLI 767

  Fly  2346 --DEFSMRYGIENIYQAMTH----------------------FHCLSAKYL----------CPG- 2375
              :.|.:..|:.:..|.:.|                      .|.:....|          |.|
Zfish   768 GWNYFHITPGMASYSQDLEHMSVAEDEDEDEKESEKRGLMEKIHMVQEIVLTVQSTLDEVACIGE 832

  Fly  2376 ---------VP-----AVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNS 2426
                     ||     |.:..|:|.:..||...          |:....:|..||.|   :|.|.
Zfish   833 RVKNTFNWSVPFLSLLACLVLLVATVGLYYIPL----------RYIVLLWGVNKFTK---KLFNP 884

  Fly  2427 LRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQ 2467
            ..||     ||      |.|..||.....:..:.:..::.:
Zfish   885 YAID-----NN------EMLDFLKRVPSDVQKVQYSELRAE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	6/48 (13%)
		C2B_Munc13	2160..2286	CDD:175993	35/125 (28%)
		DUF1041	2477..2584	CDD:283860
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
mctp2a	XP_690870.6	C2A_MCTP_PRT	246..365	CDD:176007	23/123 (19%)
		C2B_MCTP_PRT	407..519	CDD:176022	25/183 (14%)
		C2C_MCTP_PRT	559..677	CDD:176023	35/128 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920