DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and MCTP2

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001371930.1	Gene:	MCTP2 / 55784	HGNCID:	25636	Length:	878	Species:	Homo sapiens

Alignment Length:	663	Identity:	133/663 - (20%)
Similarity:	240/663 - (36%)	Gaps:	160/663 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1738 LKKKTRDRKINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEASSETSGPDT- 1801
            ||::||...||:||.....:.|...:......|.:  :.|::..|..:....:......|||.:
Human    12 LKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDR--RLSLSVPDLLEAEALAPEGRPYSGPQSS 74

  Fly  1802 ----PAELSDVDI--SETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQFDVDHSLINQPLETS 1860
                |:.||...|  ..:.:.|:..: :.:|..:..:..|      ::::.|.:.:..: |.|..
Human    75 YTSVPSSLSTAGIFPKSSSSSLKQSE-EELDWSQEEASHL------HVVETDSEEAYAS-PAERR 131

  Fly  1861 QYNTHMLENITSASI----PSQNRQI--DSKTLMSQSSHADGSQAVGNETAVGLSS--SKWKLLK 1917
            :.:::.:.::...|:    |.:..::  .|....|.:|.....|:|..|.:.|||:  |.:..|.
Human   132 RVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLL 196

  Fly  1918 TLKERKIEEKNNQDKIKEDEMIKDRDKNGGGPGEVGLRTNG---------HPGDNPFYSNIDSMP 1973
            |:            .:||...:..||:.|.....|..:.||         :...||.:..|..:|
Human   197 TI------------HLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

  Fly  1974 ----DIRPRRK--------------SIPLVSELVLKTMA----------ATKRNAGLTSAVPRAT 2010
                |.:.|.|              :..::|:|.|....          :.:.:.|:........
Human   250 IQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLV 314

  Fly  2011 LNDEDLKMHVY--KKALQA----LI--YPISSTTPHNFLLWTA-TSPTYCYECEGLLWGIARQGV 2066
            :...|.|.|.:  :|.|.|    ||  ..:|.:...| .||.. .|.|       ||.|....|.
Human   315 VKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKN-QLWNGIISIT-------LLEGKNVSGG 371

  Fly  2067 RCTECGV---------KCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAM--KDRMKQRER 2120
            ..||..|         |....||     ....:..|:...|...|:...:...:  ||..|..||
Human   372 SMTEMFVQLKLGDQRYKSKTLCK-----SANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEER 431

  Fly  2121 -------------EKPEIFEL---------------------------IRAVFSVEEKSHAGHMK 2145
                         ::....||                           :..:..:.|:.......
Human   432 LGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRY 496

  Fly  2146 AVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEK 2210
            .::.|:.|  .|....:.:.|:.|..|:|.|.||.|||:..:::...:.:|.|:.:.|||.||:.
Human   497 CLQNSLKD--VKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKV 559

  Fly  2211 FHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDK 2275
            |.|...:..|.::|.|:|||.|           :..||||:..|.:.::.......|.|:.:..:
Human   560 FTFPIKDIHDVLEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLE 613

  Fly  2276 SAVSGAIRLHISV 2288
            .|..|.|.|.:.:
Human   614 QAFKGVIYLEMDL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	15/58 (26%)
		C2B_Munc13	2160..2286	CDD:175993	37/125 (30%)
		DUF1041	2477..2584	CDD:283860
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
MCTP2	NP_001371930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..46		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..163		16/110 (15%)
		C2A_MCTP_PRT	195..314	CDD:176007	21/130 (16%)
		C2B_MCTP_PRT	357..469	CDD:176022	22/123 (18%)
		C2C_MCTP_PRT	509..627	CDD:176023	37/129 (29%)
		PRT_C	<771..>824	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920