DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-13 and UNC13C

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:NP_001074003.1 Gene:UNC13C / 440279 HGNCID:23149 Length:2214 Species:Homo sapiens


Alignment Length:2756 Identity:1039/2756 - (37%)
Similarity:1447/2756 - (52%) Gaps:685/2756 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   534 NQHLNKEPRKHRK-------------KKHHTNEMDMINKLKCILAQAQSTEIIKRDIEELGSK-- 583
            |.:.|||.|:.:|             |..:|.:..:....||......|||      |:..||  
Human    28 NTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFKSTVKKIAKCSSTHNLSTE------EDEASKEF 86

  Fly   584 -----------LSDACVKQTETENKSDNHISTSYLKDDIRKMLNNVIQTLLGEINKIKGLQSLSA 637
                       :::...|..:..| |||        :|:.:.|:::..:....:|:::     |:
Human    87 SLSPTFSYRVAIANGLQKNAKVTN-SDN--------EDLLQELSSIESSYSESLNELR-----SS 137

  Fly   638 TQLSQLQNAVWSEERFFQKIS--------LVDKKLTL--LLLNPLTVTEELQRL--CISNTNEKF 690
            |: :|.|:......|..:|.|        ..|.:.||  |.|..|....:.::.  |:|:.:|  
Human   138 TE-NQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGALRKLRKWKKSQECVSSDSE-- 199

  Fly   691 VLVIKKLKKNIDTLKKLVGSSLDDFKIDNSHANMTTFHSLNPSHNSNDSSFSAHLLRNNSNLDEQ 755
                      :.|:||..|  :....:|.:..|..| ::|.|..:|:......|           
Human   200 ----------LSTMKKSWG--IRSKSLDRTVRNPKT-NALEPGFSSSGCISQTH----------- 240

  Fly   756 LKILETQEIEIHRKKKIDEIVSGLSEETYTFNPDMEYKSQHSCTNSTDNIIGFSKNIYNEDE--- 817
                :..|:.....:.|.:|.:.|||.....|         :..:|.|.|....:.:.:|.|   
Human   241 ----DVMEMIFKELQGISQIETELSELRGHVN---------ALKHSIDEISSSVEVVQSEIEQLR 292

  Fly   818 --YIKSLRKSLERHNSMIFLLHLQNPEKHKVLADINDAQMDSNRASLSPPPPAPTDTVYLNDAIN 880
              :::|.|::.:.|:.:..|.|:                  .::|||.          :||....
Human   293 TGFVQSRRETRDIHDYIKHLGHM------------------GSKASLR----------FLNVTEE 329

  Fly   881 QITYQQRNGKSDSGLSSMSGWSANSQVSVGLQNYDPACNNILENCSERLQTYHSFPLAENSNFHS 945
            :..|.:               |...|:.:....:..|.|.|....::|:......|.|:......
Human   330 RFEYVE---------------SVVYQILIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILV 379

  Fly   946 FPLSHEQAQTTNQTEFVILEENLNYIYEL---------SKNLPICSAYENKSIFDMKYEICDSNE 1001
            :..:.:|..:..:..:.:....:....::         .|.:|....||:.:|            
Human   380 YFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYESMAI------------ 432

  Fly  1002 IGKFSTVDEMLEWDQLNEPDKQNFSGKRLNSNLMPDLLTAQIPNSISKHNKNTSVNIEYVRQKEN 1066
              |.||.:..::.:....||.   |.:.|.|:|                |:|:     |....::
Human   433 --KLSTPEPKIKKNNWQSPDD---SDEDLESDL----------------NRNS-----YAVLSKS 471

  Fly  1067 KGMDRRSIIEPN--IYNGKSEDQICRPCLTDKLVFYPSSNSITDHNSSHDFNCLSQQ-DQTRIIK 1128
            :.:.:.|..:|:  .::.:|:::              ::||....|.| |::.:|.| .::.|::
Human   472 ELLTKGSTSKPSSKSHSARSKNK--------------TANSSRISNKS-DYDKISSQLPESDILE 521

  Fly  1129 EFGSAHLNQDPTNYLDYTSGTYSKAPPEVLTHETNSSHLEFNHESESLFNSPNTSSYCKQKFVPG 1193
            :       |..|:|.|.|...:|::  :..|.:.:.|..:|:...:|.     :..:.:.:|...
Human   522 K-------QTTTHYADATPLWHSQS--DFFTAKLSRSESDFSKLCQSY-----SEDFSENQFFTR 572

  Fly  1194 TS-----PAKPSKVWKRL---NTILADNLKLKRVSKFNRSLSLPGDVQSQGLQRQPRGQAGSCPF 1250
            |:     .:...::|:|.   ...|.|:.|         ...|.|.|  ||:|.|...:      
Human   573 TNGSSLLSSSDRELWQRKQEGTATLYDSPK---------DQHLNGGV--QGIQGQTETE------ 620

  Fly  1251 IHKRSNLAGSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPDSAVSLDSAADKRFSSEKGLKKKT 1315
                                                                         ..:|
Human   621 -------------------------------------------------------------NTET 624

  Fly  1316 ISSKMSGLMQKAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGNDNSSISTREILLNQSIEV---E 1377
            :.|.||..|..|...:.|         .|||:|.:.:.:|...:          .||..::   .
Human   625 VDSGMSNGMVCASGDRSH---------YSDSQLSLHEDLSPWKE----------WNQGADLGLDS 670

  Fly  1378 DEQEDFNYKNRCDSKSVLGGSIEKLNGNLTNNLFPIVGDLKKIQSPLPLAVLTEIPSYKDEYSNK 1442
            ..||.|:|:                    ||:||                             ::
Human   671 STQEGFDYE--------------------TNSLF-----------------------------DQ 686

  Fly  1443 SDSIKNSPIEMPKILLETACNQELNLAHSD--DDVDKNILANSAKDYVNAPTFSILKTVEDASEP 1505
            ...:.|..:|.            |...|||  ||.:...|                 |.:|.|.|
Human   687 QLDVYNKDLEY------------LGKCHSDLQDDSESYDL-----------------TQDDNSSP 722

  Fly  1506 TMTPLHTTTTTNSSL-NVTSALWVTQQCLDLPNYPGWGSREDDDNRSQHSARTLSSSRRQS--TE 1567
            .           ..| |.....||.|    ..:|.|..|.|...|::|.|....|.|..||  :|
Human   723 C-----------PGLDNEPQGQWVGQ----YDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSE 772

  Fly  1568 D----------SIDTDDEYFYYELRQLEEQEK-----QRAHNSAIPSCERQNDNDVLFSQIGQLL 1617
            |          |||..|:.|.:        .|     ||| .||:         :|::::..|.|
Human   773 DAPPKSWHSRLSIDLSDKTFSF--------PKFGSTLQRA-KSAL---------EVVWNKSTQSL 819

  Fly  1618 QNDVNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELKSVVSLNPSVNNDA--TFEGVPI 1680
                   .|:..|.....|.                  |:      :|:.|..|::  |.:....
Human   820 -------SGYEDSGSSLMGR------------------FR------TLSQSTANESSTTLDSDVY 853

  Fly  1681 VKPTYEKLETVSDLHSAWQDVNGDLQIAASDIDSNEDLVGNKGRETPTYNKQRKLRRLKKKTRDR 1745
            .:|.|.|.|...|...         .:|.::.|..|.:             ::.|.:|:.:|   
Human   854 TEPYYYKAEDEEDYTE---------PVADNETDYVEVM-------------EQVLAKLENRT--- 893

  Fly  1746 KINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEASSETSGPDTPAE------ 1804
                |...|......:......||.                     .:.:..|.|.||:      
Human   894 ----SITETDEQMQAYDHLSYETPY---------------------ETPQDEGYDGPADDMVSEE 933

  Fly  1805 -LSDVDISETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQFDVDHSLINQPLETSQYNTHMLE 1868
             |..::.:..|..:|.|:.|||.                           .||:|.:: ...:..
Human   934 GLEPLNETSAEMEIREDENQNIP---------------------------EQPVEITK-PKRIRP 970

  Fly  1869 NITSASIPSQNRQ---IDSKTLMSQSSHADGSQAV--GNETAVGLSSSKWKLLKTLKERKIEEKN 1928
            :...|::.:..:|   ::.|.|...||..|....:  ||:    |.:||:..|:..         
Human   971 SFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGND----LDASKFSALQVC--------- 1022

  Fly  1929 NQDKIKEDEMIKDRDKNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTM 1993
                            .|.|.|..|               ||||||:| |:|::|:|.::.: |:
Human  1023 ----------------GGAGGGLYG---------------IDSMPDLR-RKKTLPIVRDVAM-TL 1054

  Fly  1994 AATKRNAGLTSA-VPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGL 2057
            ||  |.:||:.| |.|.:||:|:|||||:||.|||||||:|||.||||.:||||:||||||||||
Human  1055 AA--RKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGL 1117

  Fly  2058 LWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREK 2122
            ||||||||::|.||||||||||:|||||||||||||||||||||||..:||||||:|||.||:.:
Human  1118 LWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNR 1182

  Fly  2123 PEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTV 2187
            ||:||:|:.:|.:.::......||.|||||||||||||||.|||:.||||.||||:|:|||||||
Human  1183 PEVFEVIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTV 1247

  Fly  2188 QVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQT 2252
            ||.|.|:||:|:...|||||:|||:||||||:|||||||||||:|:||:::|...:|||||||||
Human  1248 QVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQT 1312

  Fly  2253 IIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCE- 2316
            |:||||||||||||||||||||||||||||||.|:|||||||||||||:|||||||||||||.| 
Human  1313 IVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEV 1377

  Fly  2317 ENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMS 2381
            ::.|.||:|..|||:|||::||:..:||||||:||||||:||||||||.|||:||:|||||||||
Human  1378 KSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMS 1442

  Fly  2382 TLLANINAYYAHTTASS--AVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPE 2444
            ||||||||:|||||.|:  .|||||||||:|||:|||:|||||||||||||||.||.|||||:.|
Human  1443 TLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTE 1507

  Fly  2445 KLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVD 2509
            :|.|||||||||||||||||||.||.|||:||.||||||:|||.|||:::|:||:|||::  ..|
Human  1508 RLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQ--LTD 1570

  Fly  2510 PNEAKRAP-DDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLF 2573
            |::.:..| :|..|...::|||.:||.|:|::|||||.:|..||||||||||:|::||..||.||
Human  1571 PSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLF 1635

  Fly  2574 AVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNEN 2638
            |:||||||||||..|||||:.||||||:|||.|:.||:|:|.:|.|||:|..||||||||||:||
Human  1636 ALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDEN 1700

  Fly  2639 DDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRF 2703
            :|||:|:||||..||||||||::|||||||.||||||.||.|.|:::.|||||:||.....||||
Human  1701 EDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRF 1765

  Fly  2704 AKTIVKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKE 2768
            ||||.|||:.||.||..:|..|...|.:.|||||||||||||||||||||||.:|:.:|:.||||
Human  1766 AKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKE 1830

  Fly  2769 LQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQRNAVAVEADEVL 2833
            ||..|:..||:|:..:..|.:..|.:.::::...|..::      |.||..:.:|:.|::|:.||
Human  1831 LQVKLSGVLDELSVTYGESFQVIIEECIKQMSFELNQMR------ANGNTTSNKNSAAMDAEIVL 1889

  Fly  2834 RPLMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPMTDKT---MMFKHLTDNAK 2895
            |.|||.||.:|:|.|:.||||||||:||||||:|:..:||.|||||:||:|   |:|        
Human  1890 RSLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIF-------- 1946

  Fly  2896 NLASNAKIEDMGRL--FKSHMAGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFH 2958
             :|:    :|:|:|  .|.||.                :|..:.|:|:|||:::|.|.|||||||
Human  1947 -IAA----KDLGQLSKLKEHMI----------------REDARGLTPRQCAIMEVVLATIKQYFH 1990

  Fly  2959 AGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVDLENSEESVGEISVQIDLF 3023
            ||||||||.||||||:|||||||||||||.||.|||.||.:|..:  ..:|:::||:|||.:|:.
Human  1991 AGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQ--SRSSKDAVGQISVHVDIT 2053

  Fly  3024 SHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNES 3088
            :.||||:|||.|||:|.|||.|| .:.||||||::.::||:|.:||||..||:|||.|||||||:
Human  2054 ATPGTGDHKVTVKVIAINDLNWQ-TTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNET 2117

  Fly  3089 FSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGW 3153
            |.|.:|.|.:...:|||:.||||||||:||::|:.||.|::|:||||...|.||::.|.|||||.
Human  2118 FQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISMDETGL 2182

  Fly  3154 TILRILSQRNNDEVAKEFVKLKSEIR 3179
            |||||||||.:|:||||||:||||.|
Human  2183 TILRILSQRTSDDVAKEFVRLKSETR 2208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 41/48 (85%)
C2B_Munc13 2160..2286 CDD:175993 98/125 (78%)
DUF1041 2477..2584 CDD:283860 61/107 (57%)
Membr_traf_MHD 2832..2992 CDD:287505 89/164 (54%)
C2C_Munc13 3032..3152 CDD:176041 69/119 (58%)
UNC13CNP_001074003.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..50 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..174 10/51 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..458 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..518 10/61 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..629 11/108 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..739 12/64 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..780 6/18 (33%)
C1 1098..1147 CDD:237996 41/48 (85%)
C2B_Munc13 1220..1346 CDD:175993 98/125 (78%)
DUF1041 1541..1646 CDD:283860 61/106 (58%)
Membr_traf_MHD 1888..2024 CDD:287505 89/164 (54%)
C2C_Munc13 2062..2181 CDD:176041 69/119 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 304 1.000 Domainoid score I1378
eggNOG 1 0.900 - - E1_KOG1011
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001626
OrthoInspector 1 1.000 - - otm41575
orthoMCL 1 0.900 - - OOG6_103034
Panther 1 1.100 - - O PTHR10480
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1191
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.770

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