Protein Alignment unc-13 and gek

DIOPT Version :10

• Sequence 1: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Sequence 2: NP_523837.2
• Gene: gek / 37858
• FlyBaseID: FBgn0023081
• Length: 1637
• Species: Drosophila melanogaster
• Alignment Length: 1368
• Identity: 248/1368 - (18%)
• Similarity: 422/1368 - (30%)
• Gaps: 540/1368 - (39%)

  Fly   995 EICDSNEIG--KFSTVDEMLEWDQLNEPDKQNFSGKRLNSNLMPDLLTAQIPNSISKHNKNTSVN 1057
            |:|....|.  |...:..:.:|:.|...:...|..:|       |:|..        .::....|
  Fly   113 EVCVVQMISTEKVYAMKILNKWEMLKRAETACFREER-------DVLVF--------GDRQWITN 162

  Fly  1058 IEYVRQKENK---------GMDRRSIIEPNIYNGKSEDQICRPCLTDKLVFYPSS-----NSITD 1108
            :.|..|....         |.|..:::      .|.||::..    |...||.:.     |||..
  Fly   163 LHYAFQDNINLYLVMDYYCGGDLLTLL------SKFEDKLPE----DMAKFYITEMILAINSIHQ 217

  Fly  1109 HNSSH-----DFNCLSQQDQTRIIKEFGSA-HLNQDPTNYLDYTSGTYSKAPPEVL--------- 1158
            ....|     |...|.::...| :.:|||. .|::|.|...:...||.....||:|
  Fly   218 IRYVHRDIKPDNVLLDKRGHVR-LADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGR 281

  Fly  1159 -------------THETNSSHLEFNHES-----------ESLFNSPN--TSSY----------CK 1187
                         .:|.......|..||           ::.||.|:  |.:|          ||
  Fly   282 YGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCK 346

  Fly  1188 QKFVPGTSPAK---------PSKV---WKRLNTILADNLKLKRVSKFNRSLSLPGDVQSQGL--- 1237
            ...:|.....:         |..|   ||.:.         :..:.:...:|.|.|..:..:
  Fly   347 LICIPENRLGQNGIQDFMDHPWFVGIDWKNIR---------QGPAPYVPEVSSPTDTSNFDVDDN 402

  Fly  1238 ----------QRQPRGQAGSCPFIHKRSNLAGSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPD 1292
                      ...|.......|||....:|..|....||:.|       ....|...:...|||.
  Fly   403 DVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQ-------SSGFGDDTLDTISSPQ 460

  Fly  1293 SAVSLDSAADKRFSSEKGLKKKTISSKMSGLMQ-KAKTYKRHSFVLRRGCNMSDSELEMPDFVSS 1356
            .|:...:.::....|   ::.|.::.:::.|.| ||:..|:|:.|..| ....||||:
  Fly   461 LAILPSNNSETPVDS---VQLKALNDQLAALKQEKAELSKQHNEVFER-LKTQDSELQ------- 514

  Fly  1357 GNDNSSISTREILLNQSIEVEDEQEDF-NYKNRC-----DSKSVLGGSIEKLNGNLTNNL----- 1410
                .:||.|.|.:.:..||.::..:. |.|.:.     |.:..|.|:::| |.:|.|.|
  Fly   515 ----DAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQK-NDSLRNELRKSDK 574

  Fly  1411 ------------------------------FPIVGDLKK----IQSPLPLAVLTEIPSYKDEYSN 1441
                                          ..:..:|:|    :::.:||::.:|:.||:.|
  Fly   575 TRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIE--- 636

  Fly  1442 KSDSIKNSPIEMPKILLETACNQELNLAHSDDDVDKNILANSAKDYVNAPTFSILKTVEDASEPT 1506
                           .||...:::|:...:..:::...|...         ||.|:
  Fly   637 ---------------RLELQFSEKLSHQQTRHNMELEALREQ---------FSELE--------- 668

  Fly  1507 MTPLHTTTTTNSSLNVTSALWVTQQCLDLPNYPGWGSREDD-----DNRSQHSARTLS---SSRR 1563
                      |::|.:|..|..||:.|   .|....|..|.     :.:.||.....|   ..:|
  Fly   669 ----------NANLALTKELQQTQERL---KYTQMESITDSAETLLELKKQHDLEKSSWFEEKQR 720

  Fly  1564 QSTE--------DSIDTDDEYFYYELRQLEEQEKQRAHNSAIPSCERQNDNDVLFSQIGQLLQND 1620
            .|:|        ..:..:|:..:.|||...|         ||...||         |:.:::|
  Fly   721 LSSEVNLKSKSLKELQAEDDEIFKELRMKRE---------AITLWER---------QMAEIIQ-- 765

  Fly  1621 VNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELKSVVSLNPSVNNDATFEGVPIVKPTY 1685
                       ..:|.:||..:  .:::..:|:|..:.||.|.:.|.:..::..:......|  .
  Fly   766 -----------WVSDEKDARGY--LQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQK--L 815

  Fly  1686 EKLETVSDLHSAWQDVNGDLQIAASDIDSNE------DLVGNKGRETPTYNKQRK--LRRLKKKT 1742
            :|:|.: :|.||.|     .:|.|.::.|:|      ||:..: :|...|.|:..  |...:||.
  Fly   816 DKMELL-NLQSALQ-----REIQAKNMISDELSQTRSDLISTQ-KEVRDYKKRYDSILHDFQKKE 873

  Fly  1743 RDRKINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEA--SSETSGPDTPAEL 1805
            .:.: ::.|.....|.|.         |.:.|...::.....|:|..||.  |:|:.|
  Fly   874 TELR-DLQKGGLEYSESF---------LNKSTHHGLSSAFFRDMSKNSEIIDSAESFG------- 921

  Fly  1806 SDVDISETENGLRADDGQNIDN------MRGNSGSLLKVNRKYLLQFDVDHSLINQPLETSQYNT 1864
                   .|:|         ||      ..||||.|.....||..:.:.|||
  Fly   922 -------NESG---------DNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHS------------- 957

  Fly  1865 HMLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAVGLSSSKWKLLKTLKERKIEEKNN 1929
                                                                 ::||..:.:.:.
  Fly   958 -----------------------------------------------------SMKEASVSDLSR 969

  Fly  1930 QDKIKEDEMIKDRDKNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTMA 1994
            ::   .|:::|:..|.
  Fly   970 EE---SDQLVKESQKK------------------------------------------------- 982

  Fly  1995 ATKRNAGLTSAVPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLW 2059
                       ||                         .:|..|.||:.|.:|||.|..|..|:.
  Fly   983 -----------VP-------------------------GNTAIHQFLVRTFSSPTKCNHCTSLMV 1011

  Fly  2060 GIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPE 2124
            |:.||||.|..||..||..|                        ...:.|.....|.|.:|  |.
  Fly  1012 GLTRQGVVCEICGFACHTIC------------------------CQKVPTTCPVPMDQTKR--PL 1050

  Fly  2125 IFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQV 2189
            ..:..|.:.:..|    |::|..|..|:  ...|..:  ..|:|...|...|.|.......:|.|
  Fly  1051 GIDPTRGIGTAYE----GYVKVPKSGVI--KRGWIRQ--FVVVCDFKLFLYDISPDRCALPSVSV 1107

  Fly  2190 SKV 2192
            |:|
  Fly  1108 SQV 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2019..2100	CDD:412127	22/80 (28%)
		C2B_Munc13	2160..2286	CDD:175993	9/33 (27%)
		MUN	2477..2996	CDD:461870
		C2C_Munc13	3032..3152	CDD:176041
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	62/351 (18%)
		KELK	477..556	CDD:464876	22/90 (24%)
		CCDC158	<481..>894	CDD:464943	102/526 (19%)
		C1_MRCK	990..1042	CDD:410359	22/75 (29%)
		PH_MRCK	1049..1182	CDD:269949	17/70 (24%)
		CNH	1215..1484	CDD:459938
		CRIB	1544..1580	CDD:238077