DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and Mctp2

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001178554.1	Gene:	Mctp2 / 308742	RGDID:	1562967	Length:	872	Species:	Rattus norvegicus

Alignment Length:	682	Identity:	135/682 - (19%)
Similarity:	228/682 - (33%)	Gaps:	204/682 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1738 LKKKTRDRKINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEASS------ET 1796
            ||::||...||:||.....|.|        .||....|..:..:.:..:.:..||.:      ..
  Rat    12 LKQRTRPLLINLSKKKAKKSPS--------KPLDLRVQHHLDRRLSLSVPDLLEAEALVPEGRPY 68

  Fly  1797 SGPDT-----PAELSDVDI-----------SETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQ 1845
            |||.:     |..||...|           ||.|.....::..::..:..:|..:.....:....
  Rat    69 SGPQSSYISVPNSLSTAGIVPKSSSSSLKQSEEELEWSQEEASHVPGVDTDSEEIYASPAEEWQA 133

  Fly  1846 FDVD----HSLINQPLETSQYNTHMLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAV 1906
            |...    |....:|     ..||..::: :||:.||  |.:.:..:.::|           ..|
  Rat   134 FSQSGLDLHKAPEEP-----EKTHGSDDL-NASMSSQ--QFEEQLTLGEAS-----------DCV 179

  Fly  1907 GLSSSKWKLLKTLKERKIEEKNNQDKIKEDEMIKDRDKNGGGPGEVGLRTNG---------HPGD 1962
            ....|.:..|.|:            .:||...:..||:.|.....|..:.||         :...
  Rat   180 SHLPSPFAYLLTI------------HLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNL 232

  Fly  1963 NPFYSNIDSMP------DIRPRRKSIPLVSE-------LVLKTMAATKRNAGLTSAVPRATLNDE 2014
            ||.:..|..:|      .:|.:.....|...       :||:.:...:....:.......:|.|:
  Rat   233 NPIWDEIVVLPIQSLDQKLRVKVYDRDLTKSDFMGSAFVVLRDLELNRTTEHILKLEDPNSLEDD 297

  Fly  2015 ---------------DLKMHVY--KKALQA----LI--YPISSTTPHNFLLWTA-TSPTYCYECE 2055
                           |.|...:  :|.|.|    ||  ..:|.:...| .||.. .|.|
  Rat   298 MGVIVLNLNLVVKQGDFKRQRWSNRKRLSASKSSLIRNLRLSESLRKN-QLWNGIISIT------ 355

  Fly  2056 GLLWGIARQGVRCTECGVKC-----HEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAM--KD 2113
             ||.|....|...||..|:.     ..|.|.|..::..| ..|:...|...|:...:...:  ||
  Rat   356 -LLEGKNVSGGNMTEMFVQLKLGEQRYKSKTLCKSENPQ-WQEQFDFHYFSDRMGILDIEVWGKD 418

  Fly  2114 RMKQRER----------------------------------------------------EKPEIF 2126
            ..|..||                                                    |.|...
  Rat   419 NKKHEERLGTCKVDISALPLKQDNCLELPLESCQGALLMLITLTPCTAVSISDLCVCPLEDPSER 483

  Fly  2127 ELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSK 2191
            :||...::::..     :|.||...:         :.:.|:.|..|:|.|.||.|||:..:::..
  Rat   484 QLISQRYALQNS-----LKDVKDVGI---------LQVKVLKAADLLAADFSGKSDPFCLLELGN 534

  Fly  2192 VKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEV 2256
            .:.:|.|:.:.|||.||:.|.|...:..|.::|.|:|||.|           ::.||||:..|.:
  Rat   535 DRLQTHTIYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGD-----------KAPDFLGKVAIPL 588

  Fly  2257 RTLSGEMDVWYNLEKRTDKSAVSGAIRLHISV 2288
            .::.......|.|:.:..:.|..|.|.|.:.:
  Rat   589 LSIRDGQPNCYVLKNKDLEQAFKGLIYLELDL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	15/54 (28%)
		C2B_Munc13	2160..2286	CDD:175993	37/125 (30%)
		DUF1041	2477..2584	CDD:283860
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
Mctp2	NP_001178554.1	C2A_MCTP_PRT	189..308	CDD:176007	20/130 (15%)
		C2B_MCTP_PRT	351..463	CDD:176022	21/119 (18%)
		C2C_MCTP_PRT	503..621	CDD:176023	37/138 (27%)
		PRT_C	<765..>818	CDD:285560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010