DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-13 and Mctp2

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001019874.1	Gene:	Mctp2 / 244049	MGIID:	2685335	Length:	878	Species:	Mus musculus

Alignment Length:	728	Identity:	133/728 - (18%)
Similarity:	250/728 - (34%)	Gaps:	214/728 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1643 SPSESVKL--------RMSEVFKELKSVVSLNP-------------SVNNDATFEGV------PI 1680
            |||:.:.|        |:|....:|....:|.|             ||.|..:..|:      ..
Mouse    31 SPSKPLDLRVQHHLDRRLSLSVPDLLEAEALAPEGRPYSGPQSSYISVPNSLSTAGIVPKSSSSS 95

  Fly  1681 VKPTYEKL----ETVSDLHSAWQDVNGDLQIAASDIDSNEDLVGNKGRETPTYNKQRKLRRLKKK 1741
            :|.:.|:|    |..|.:|..             |.|| |::..:...|...::         :.
Mouse    96 LKQSEEELDWSQEEASHVHGV-------------DTDS-EEIYASPAEEWQAFS---------QS 137

  Fly  1742 TRD-RKINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEASSETSGPDTP-AE 1804
            ..| .|.::.::|.......|..::.|.        |:..:...:.|...|||...|...:| |.
Mouse   138 ALDLHKPSLGRDAPEEHDKTHGNDDLNA--------SMTSQHFEEESTLGEASDCVSHLPSPFAY 194

  Fly  1805 LSDVDISETENGLRADDGQNIDNMRGNSGS-----LLKVNRKYLLQFDVDHSLINQPLETSQYNT 1864
            |..:.:.|         |:|: .:|...|:     ..|:|.|.|.:..|.:..:|.
Mouse   195 LLTIHLKE---------GRNL-VVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP--------- 240

  Fly  1865 HMLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAVGLSSSKWKLLKTLKER------- 1922
             :.:.|....|.|.::::..|......:.:|            ...|.:.:|:.|:..
Mouse   241 -IWDEIVVLPIQSLDQKLRVKVYDRDLTKSD------------FMGSAFVVLRDLELNRTTEHIL 292

  Fly  1923 KIEEKNNQDK------------IKEDEMIKDRDKN----GGGPGEV--GLRTNGHPGDNPFYSNI 1969
            |:|:.|:.:.            :|:.:..:.|..|    ......:  .||.:.....|..::.|
Mouse   293 KLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLRKNQLWNGI 357

  Fly  1970 DSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLT---SAVPRATLNDEDLKMHVYKKALQALIYP 2031
            .|:..:..:..|...::|:.::.....:|....|   ||.|:.   .|....|.:...:..|...
Mouse   358 ISITLLEGKNVSGGNMTEMFVQLKLGEQRYKSKTLCKSANPQW---QEQFDFHYFSDRMGILDIE 419

  Fly  2032 I--SSTTPHNFLLWTA--------TSPTYCYE-----CEGLLWGIARQGVRCTEC-GVKCHEKCK 2080
            :  ..:..|...|.|.        .....|.|     |:|.|..:    :..|.| ||...:.|
Mouse   420 VWGKDSKKHEERLGTCKVDISALPLKQDNCLELPLESCQGALLML----ITLTPCTGVSISDLC- 479

  Fly  2081 DLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSHAGHMK 2145
                                       :...:|..::::..:...|:              ..:|
Mouse   480 ---------------------------VCPFEDPSERQQISQRYAFQ--------------NSLK 503

  Fly  2146 AVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEK 2210
            .||...:         :.:.|:.|..|:|.|.||.|||:..:::...:.:|.|:.:.|||.||:.
Mouse   504 DVKDVGI---------LQVKVLKASDLLAADFSGKSDPFCLLELGNDRLQTHTIYKNLNPEWNKV 559

  Fly  2211 FHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDK 2275
            |.|...:..|.::|.|:|||.|           ::.||||:..|.:.::.......|.|:.:..:
Mouse   560 FTFPIKDIHDVLEVTVFDEDGD-----------KAPDFLGKVAIPLLSIRDGQPNCYVLKNKDLE 613

  Fly  2276 SAVSGAIRLHISV 2288
            .|..|.|.|.:.:
Mouse   614 QAFKGLIYLELDL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	13/62 (21%)
		C2B_Munc13	2160..2286	CDD:175993	37/125 (30%)
		DUF1041	2477..2584	CDD:283860
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
Mctp2	NP_001019874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..40		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..178		6/42 (14%)
		C2A_MCTP_PRT	195..314	CDD:176007	23/150 (15%)
		C2B_MCTP_PRT	357..469	CDD:176022	20/118 (17%)
		C2C_MCTP_PRT	509..627	CDD:176023	37/138 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..752
		PRT_C	<771..>824	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010