DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-13 and Unc13c

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:XP_006510991.1 Gene:Unc13c / 208898 MGIID:2149021 Length:2220 Species:Mus musculus


Alignment Length:2384 Identity:990/2384 - (41%)
Similarity:1351/2384 - (56%) Gaps:408/2384 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1032 SNLMPDLLTAQI----PNSISKHNKNTSVNIEYVRQKENKGMDRRSIIE-PNIYNG-KSEDQICR 1090
            ::|...|:.|.|    ....:|...||:...|..:||:::........: |.:.|. ||..:...
Mouse     3 ASLFKSLILAYIHKLCKGMFTKKLGNTTKKKENRQQKKDQDFPTAGHTKPPKLSNALKSTVKKIA 67

  Fly  1091 PCLTDKLVFYPSSNSITDHNSSHDFNCLSQQDQTRIIKEFG--SAHLNQDPTNYLDYTS--GTYS 1151
            .|.:.:      :.||.|.....||: ||.....|:....|  :|..|.|.....:.:|  .:||
Mouse    68 KCSSTR------NFSIEDEEGHKDFS-LSPTFSYRVAIANGLQTAVTNSDEDLLQELSSIESSYS 125

  Fly  1152 KAPPEVLTHETNSSHLEFNHESESLFNSPNTSSYCKQKFVPGTSPAKPS------------KVWK 1204
            ::..|:  ..:..:.::..|......|..::||....:   |:|..:.:            :.||
Mouse   126 ESFNEL--RSSTENQVQSTHTMPVRRNRKSSSSLAPSE---GSSDGERTLHTLKLGALRKLRKWK 185

  Fly  1205 RLNTILADNLKLKRVSKFNRSLSLPGDVQSQGLQRQPR-----------GQAGSCPFIHKRSNLA 1258
            :....::.:.:|..|.|       ...::|:.|.|..|           ..:|.....|....:.
Mouse   186 KSQECVSSDSELSTVKK-------TWGIRSKSLDRTARNPKTNVLEPGFSSSGCISQTHDVMEMI 243

  Fly  1259 GSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPDSAVSLDSAADKRFSSEKGLKKKTISSKMSGL 1323
            ...:|...:|:.......|....:.:           |:|     ..||...:.:..|....:|.
Mouse   244 FKELQGISQIETELSELRGHVNALKY-----------SID-----EISSSVEVVQSEIEQLRTGF 292

  Fly  1324 MQ-KAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGNDNSSISTREILLNQSIEVEDEQEDFNYKN 1387
            :| :.:|...|.::..                 .|:..|.:|.|  .||...|..:..|...|: 
Mouse   293 VQARRETRDIHDYIKH-----------------LGHMGSKVSLR--FLNVPEERHEYVESVVYQ- 337

  Fly  1388 RCDSKSVLGGSIEKLNGNLTNNLFPI-----VGDLKKIQS--PLPLAVLTEIPSYKDEYSNKSDS 1445
                  :|   |:|:..:...|...|     :|..:...:  |.|:.|..|.|..:|....||..
Mouse   338 ------IL---IDKMGFSDVPNAIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSYK 393

  Fly  1446 IKNSPIEMPKILLETACNQELNLAHSDDDVDKNILANSAKDYVNAPTFSILKTVEDASEPT---- 1506
            :|.:.|.:...:|.....:.         .:|.:|.:|       .|:..:.......||.    
Mouse   394 LKGTGIGISTDILTYDIRER---------KEKGVLPSS-------QTYESMDMKLSTPEPKAKKN 442

  Fly  1507 --MTPLHTTTTTNSSLNVTSALWVTQQCLDLPNYPGWGSREDDDNRSQHSARTLSSSRRQSTEDS 1569
              ::|..:.....|.|:.:|          ..:.|..||.....::| ||||:.:.:....|...
Mouse   443 AWLSPNDSDRELESDLSRSS----------YADSPAKGSSSKSSSKS-HSARSKNKAANSRTSQK 496

  Fly  1570 IDTDDEYFYYELRQLE-----EQEKQRAH--NSAIPSCERQNDNDVL--------FSQIGQLLQN 1619
            .|       |..|..:     ..|||..|  .:..|....|:|...|        ||::.|....
Mouse   497 SD-------YNKRPSQPPASSTPEKQTPHYVEATPPLWHSQSDFFTLKLSRSESDFSKLCQSYSE 554

  Fly  1620 DVNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELKSVVSLNPSVNNDATFEGVPIV--K 1682
            |.:....|..:||     .:::.|....:..|..|      .:.:|...:.:....|.:|.|  :
Mouse   555 DFSESQFFCRTNG-----SSLLSSSDRELWQRKQE------GMPALYHRLQDQGLDETIPAVPGQ 608

  Fly  1683 PTYEKLETV-SDLHSAWQDVNGD-LQIAASDIDSNEDL------------VGNKGRETPTYNKQR 1733
            ...|..||| |.:.::....:|| ...:.|.:..:|||            ..:.|.::.|   |.
Mouse   609 AEIENTETVDSGMSNSMVCASGDRSNYSGSQLSLHEDLSPWKEWNQAGQGTDDVGLDSST---QE 670

  Fly  1734 KLRRLKKKTRDRKINISKNATSSSSSCHSE----------------NEC----NTPLGQCTQK-- 1776
            ..........|:::::|.........|||:                :.|    |.|.||...:  
Mouse   671 PFDYDTNSLSDQQLDLSSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYD 735

  Fly  1777 SVAEKDTNDI-----------SNKSEASSETSGPDTP----AELSDVDISE-------------- 1812
            |..|.::||:           .::||..|:.|....|    :.|| :|:|:              
Mouse   736 SYQEANSNDLYPNQSHPSMMYRSQSELQSDDSEGAQPKSWHSRLS-IDLSDKTFKFPKFGSTLQR 799

  Fly  1813 TENGLRADDGQNIDNMRG--NSGSLLKVNRKYLLQ-------FDVDHSLINQP------------ 1856
            .::.|.....::..::.|  :|||.|....:.|.|       ..:|..:..:|            
Mouse   800 AKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYKAEEEEDYC 864

  Fly  1857 ----------LETSQYNTHMLENITSAS---------------IPSQNRQIDSKTLMSQSSHADG 1896
                      :|..:.....|||.||.:               .|.:..|.:.....:....::|
Mouse   865 EPVADSETDYVEVMEQVLAKLENRTSITEVNEHIKDYDHPSYETPYETPQDEGYDGQADDIISEG 929

  Fly  1897 SQAVGNETAVGLS------------------------SSKWKLLKTLKER--KIEEK---NNQDK 1932
            .....||.||.:.                        |.|...|:..|::  ::|||   .:...
Mouse   930 ELETLNEPAVEMELAEDENQNLPAESLEVMKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSS 994

  Fly  1933 IKEDEMI---KDRDKN---------GGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLV 1985
            :.|...|   .|.|.:         |.|.|..|               ||||||:| |:|::|:|
Mouse   995 MDEKARIVSGNDLDASKFSALQVFGGAGRGLYG---------------IDSMPDLR-RKKTLPIV 1043

  Fly  1986 SELVLKTMAATKRNAGLTSA-VPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPT 2049
            .::.: |:||  |.:||:.| |.|.:||:|:|||||::|.||||||||||||||||.:||||:||
Mouse  1044 RDVAM-TLAA--RKSGLSLAMVIRTSLNNEELKMHVFRKTLQALIYPISSTTPHNFEVWTATTPT 1105

  Fly  2050 YCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDR 2114
            ||||||||||||||||::|.||||||||||:|||||||||||||||||||||||..:||||||:|
Mouse  1106 YCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKER 1170

  Fly  2115 MKQREREKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSG 2179
            ||.|||.:||:||:|:.:|.:.::....:.||.|||||||||||||||.|||:.||||.||||:|
Mouse  1171 MKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTG 1235

  Fly  2180 TSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRE 2244
            :|||||||||.|.|:||:|:...|||||:|||.||||||:|||||||||||:|:||:::|...:|
Mouse  1236 SSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFFFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKE 1300

  Fly  2245 SDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHEN 2309
            |||||||||:||||||||||||||||||||||||||||||.|:|||||||||||||:||||||||
Mouse  1301 SDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHEN 1365

  Fly  2310 LFHYLCE-ENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLC 2373
            |||||.| ::.|.||:|..|||:|||::||:..:||||||:||||:|:||||||||.|||:||:|
Mouse  1366 LFHYLTEVKSNGSVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGVESIYQAMTHFSCLSSKYMC 1430

  Fly  2374 PGVPAVMSTLLANINAYYAHTTASS--AVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRN 2436
            ||||||||.|||||||:|||||.|:  .|||||||||:|||:|||:|||||||||||||||.||.
Mouse  1431 PGVPAVMSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRE 1495

  Fly  2437 NFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYEL 2501
            |||||:.|:|.|||||||||||||||||||.||.|||:||.||||||:|||.|||:::|:||:||
Mouse  1496 NFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKYIFDNCHEL 1560

  Fly  2502 YNREFQVDPNEAKRAP-DDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLS 2565
            |::  .:||::.:..| :|..|...::|||.:||.|:|::|||||.:|..||||||||||:|::|
Mouse  1561 YSQ--LIDPSKKQDVPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKIS 1623

  Fly  2566 ASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPF 2630
            |..||.|||:||||||||||:.|||||:.||||||:|||.|:.||:|:|.:|.|||:|..|||||
Mouse  1624 AEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPF 1688

  Fly  2631 VMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEI 2695
            |||||:||:|||:|:||||..||||||||::|:|||||.||||||.||.|.|:::.|||||:||.
Mouse  1689 VMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEA 1753

  Fly  2696 WKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDERIACILMNNIQQLRVQLEKMFESMGGD---- 2756
            ....||||||||.|||:.||.||..:|..:...|.:.|||||||||||||||||||||||.    
Mouse  1754 LSHLMRRFAKTINKVLVQYAAIVSNDFSSYCDKETVPCILMNNIQQLRVQLEKMFESMGGKEKKE 1818

  Fly  2757 ------KLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGGSGTLAA 2815
                  :|:.:|:.||||||..||..||.|:..:..|.:..|.:.::::|..|..::      |.
Mouse  1819 GERFSYELDPEASTILKELQIKLNGVLDALSITYGESFQLTIEECIKQMGAELNQMR------AN 1877

  Fly  2816 GNLAAQRNAVAVEADEVLRPLMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEKTIVLPPM 2880
            ||..|.:|:.|::|:.|||||||.||.:|:|.|:.||||||||:||||||:|:..:||.|||||:
Mouse  1878 GNSTANKNSAAMDAEIVLRPLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPL 1942

  Fly  2881 TDKT---MMFKHLTDNAKNLASNAKIEDMGRL--FKSHMAGKQDVKSALSGVMDISKEVEKNLSP 2940
            ||:|   |:|         :|:    :|:|:|  .|.||.                :|..|.|:|
Mouse  1943 TDQTGPQMIF---------IAA----KDLGQLSKLKEHMI----------------REDAKGLTP 1978

  Fly  2941 KQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKTFISSQVHEVD 3005
            :|||:::|.|.|||||||||||||||.||||||:|.|||||||||||.||.|||.||.:|..:  
Mouse  1979 RQCAIVEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQTTDALIKKFIETQGSQ-- 2041

  Fly  3006 LENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINLIGPHLQEKKR 3070
            ..:|:::||:|||.:|:.:.||||:|||.|||:|.|||.|| .:.||||||::.::||.|.:|||
Mouse  2042 SRSSKDAVGQISVHVDVTTTPGTGDHKVTVKVIAINDLNWQ-TTAMFRPFVEVCMLGPSLGDKKR 2105

  Fly  3071 KFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVIPLKDISEKGS 3135
            |..||:|||.|||||||:|.|.:|||.:...:|||:.||||||||:||::|:.||.|::|:||||
Mouse  2106 KQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGS 2170

  Fly  3136 VACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIR 3179
            ...|.||::.:.|||||.|||||||||.:|:||||||:||||.|
Mouse  2171 YGAWYPLLKNLSMDETGLTILRILSQRTSDDVAKEFVRLKSETR 2214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 41/48 (85%)
C2B_Munc13 2160..2286 CDD:175993 98/125 (78%)
DUF1041 2477..2584 CDD:283860 61/107 (57%)
Membr_traf_MHD 2832..2992 CDD:287505 90/164 (55%)
C2C_Munc13 3032..3152 CDD:176041 69/119 (58%)
Unc13cXP_006510991.1 C1 1094..1143 CDD:237996 41/48 (85%)
C2B_Munc13 1216..1342 CDD:175993 98/125 (78%)
DUF1041 1536..1640 CDD:368829 59/105 (56%)
Membr_traf_MHD 1894..2030 CDD:371123 90/164 (55%)
C2C_Munc13 2068..2187 CDD:176041 69/119 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 303 1.000 Domainoid score I1390
eggNOG 1 0.900 - - E1_KOG1011
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001626
OrthoInspector 1 1.000 - - otm43624
orthoMCL 1 0.900 - - OOG6_103034
Panther 1 1.100 - - O PTHR10480
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1191
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.810

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