DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and UNC13B

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	NP_001358118.1	Gene:	UNC13B / 10497	HGNCID:	12566	Length:	4340	Species:	Homo sapiens

Alignment Length:	3908	Identity:	1331/3908 - (34%)
Similarity:	1884/3908 - (48%)	Gaps:	1010/3908 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QLLKKELKINTQEKLIFAENALKS------QIKIKEQLRLQQQSTIYASSLLSSSAAGSVRAPLL 76
            :|.|:|..::.....|.|.|....      |:...|.| |..|.|...|:|:||:
Human   691 ELNKREGTLDNYSSSIIALNGSDEETTGWFQMPTSENL-LSSQVTSEPSNLVSSA---------- 744

  Fly    77 SQGHLNSIQHNMDFDLAKAQIPEMQPPMSKSPNGLDFSYLSYPSI----NTNESMISIKSEQQLC 137
            |:...:.::..:..||  :.:|:.|...:|...|       :|.|    ..|:.:.|...|:
Human   745 SKNDESLLEEKLCIDL--SLLPDQQKICAKDTPG-------HPCIAGSRTANKEVFSKPLEE--- 797

  Fly   138 QSYNSEQHSDYIISDYMDKIATRISLLETELK----FAWRALDLLSTEYGKIWIRLEKLENISIE 198
                             ||:......||...|    |...:.:..|.|.....:::.::|...:|
Human   798 -----------------DKVTGNDDFLEPLRKSFSQFLLTSPETCSKESLSEPVKIRQVEEDGLE 845

  Fly   199 QQ--------SVVGNL----VDLIGASKKELQKVDIERMKVPLYQ-------------------- 231
            :.        |..|.|    ...:|.|:|: |::..:....||::
Human   846 RGSKKDGHSFSFSGKLNLPFFRSLGHSEKQ-QELKEKGSIFPLFKFSFTDSKVTVNDQSLRGSAV 909

  Fly   232 --DEDQLLPLEMEDTLDIDIQSS-----NRDFDKNLTFENHEKTFVTKHTQATKSEDLMNSAYAI 289
              ||:...... |||....|:||     :.|..|   |::.|:  ..|:.|....||...::...
Human   910 TTDEESKKNCH-EDTKHSSIKSSSVPNIHSDLGK---FDSTEE--FKKNDQINCPEDAKLNSIKS 968

  Fly   290 DSHPN-------FENI-DFNGKNLDIGIIK----FGFEKGYEPKQKGNQSDFEAYKESRTKLYSD 342
            .|.||       |::| :|| ||..:...:    ...:.|..|..:.|...|::.:|     ::.
Human   969 SSVPNIHDDLEKFDSIKEFN-KNDQVNCPEDAKLSSIKSGSAPNTQDNLGKFDSTEE-----FNQ 1027

  Fly   343 SDLMLYERQQFLANS---ARAELMK------------EFLNGRRVLNEISASSGALSKSSEKDKN 392
            :|.:         ||   |:..::|            :|.|    :.|::.|.....::.|:|..
Human  1028 NDQI---------NSPEDAKFNIIKSDSVTNINNDLGKFGN----IEELNPSDHTAGQNFERDGL 1079

  Fly   393 L---VKPREPLLSEIDDTYVRRSTCELVSP--SSNNFFQIAASKTGEGGNQVLPIEDTGGTESPA 452
            .   |.|:|.:.|:               |  ...|..|.|:|...:..     :|....|....
Human  1080 AIPGVVPKEHITSD---------------PLGEDKNLIQAASSVASDSS-----LECISTTSKST 1124

  Fly   453 NINEVDE--------------SFYKNLNEAYRDNE-LSSEIFKV---DALLHQSEATHDHISFIR 499
            .:||::|              ||...|...:...| |||:...:   |:  |....|...||.|.
Human  1125 LVNEINEDEVIDKTSKKNTQGSFLSGLFNRFSSAENLSSQELNLKNDDS--HHKNNTPGLISGIF 1187

  Fly   500 NQSTSSPVLNNQ----------RVNAITGTQPLQ----TAKACLVTE-PNQHLNKE--------- 540
            |..::|.:::::          .:.::.|...|.    .|.:|:.:| |..|:.|.
Human  1188 NLLSNSGMIDHKPEEAKFMSLGNMKSLNGDNHLSLDEVPATSCVTSENPKNHVEKHETSSFIEAS 1252

  Fly   541 --PRKH--------------------RKKKHHTNEMDMINKLKCI-----------LAQAQ-STE 571
              |:::                    :.:|||.:..:::  |.|.           :|:.| ...
Human  1253 LLPKENIPLSDAGDDNHYCSPTEKNQQSEKHHPSSENIV--LHCAPSAQLGFLEKSMAKRQMPNH 1315

  Fly   572 IIKRDIEELGSKLSDACVKQTETENKSDNHISTSYLK--------DDIRKMLNN--VIQTLLGEI 626
            :::..:.|..:||:.. |..|...|||:|:.:...:.        .||:.:..|  .:|.:...:
Human  1316 VLEAKLHENSNKLNSP-VLNTNILNKSNNYQAFEEMNSPFCFEWDSDIKDLSKNSRKLQPVYYML 1379

  Fly   627 NKIKGLQSLSATQLSQLQNAVWSEERFFQKISLVDKKLTLL--LLNPLTVT------EELQRLCI 683
            |:.:.|.:.:...|.. :|:|.:   |.||    |:...:|  ..||.:|.      |...:|..
Human  1380 NQNRFLSADACLWLDS-ENSVIN---FCQK----DQNANILEWRTNPNSVIWCDLPYESFNQLAF 1436

  Fly   684 SNTNEKFVLVIKKLKKNIDTLKKLVG-----------SSLDDFKID---NSHANMTTF-----HS 729
               ||.::     |:.::.....|.|           :||::..||   :|....||.     .|
Human  1437 ---NEDYL-----LRGDVWAANSLYGNSGPLPINEANNSLEELPIDLSSSSDHEKTTCPVVDQES 1493

  Fly   730 LNPSHNSNDSSFSAHLLRNNSNLDEQLKILE------TQEIE-----IHRKKKIDEIVS-GLSEE 782
            |....|...|||       .....|.|..||      :::.:     .|..:.|..::: ...:.
Human  1494 LRMDENFVFSSF-------GYEYQEWLSCLEHGVWWPSEDGDYGYYMFHDGQYIYSLLTDSTGQY 1551

  Fly   783 TYTFNPDMEYKSQHSCTNSTDNIIGFSKNIYNEDEYIKSLR-KSLERHNSMIFLLHLQNPEKHKV 846
            .|.|.|| .|:....|...|:.:    .:|..:|..|.:.. |.|::.:.:.:.:     |:..:
Human  1552 AYLFIPD-SYQEYLDCDLQTNGL----SSITLDDSIISACSFKVLDKEDEIFWYV-----EEEPI 1606

  Fly   847 LADINDAQMDSNRASLSPPPPAPTDTVYLN-DAINQITYQQRNGKSDSGLSSMSGW--------- 901
                 |..:|     ||...|...:.:||| :..:|:..:....:||..| ..||:
Human  1607 -----DDPLD-----LSLALPRSEEPLYLNLETFSQVLKESSCDQSDQPL-DFSGYNRQKFKGDF 1660

  Fly   902 ---------SANSQVSVGLQNYDPACNNILENCSERLQTYHSFPLAEN-----SNFHSFPLSHEQ 952
                     |.:::.::.|:|.....:|.:.:..:.::...:.||||:     |:||....|.|:
Human  1661 RSFKERPCGSEDAECTLDLRNQPQTISNHVSSRDQIIERDKNQPLAEDSSVHLSSFHWLQSSVEE 1725

  Fly   953 AQT----TNQTEFVILEENLNYIYELSKNLPICSAYENKSIFDMKYEICDSNEIGKFSTVDEMLE 1013
            ..|    .|.|:.....|..:.:.:::....:..|....:   :|::..:|.|......|::..:
Human  1726 VTTLVHPENMTKGSQQAEETSLVNKVASVFSVLGASVGST---LKFDKSESLEALAMQKVNQQSD 1787

  Fly  1014 WDQL-NEPDKQNFSGKRLNSNLMPDLLTAQIPNSISKHNKNTSVN-------IEYVRQK----EN 1066
            ..:| |:..:.....|:|..|      :..:..|:.|.::...|:       |:.:||:    :|
Human  1788 LAELTNDGFQSLIMSKQLEGN------SPNVEKSLLKDSERQIVSNVQHPELIKNIRQEFSLNKN 1846

  Fly  1067 KGMDRRSIIE---------PNIYNGKSEDQICRPCLTDKLVFYPSSNSITDHNSSHD-------- 1114
            ..:.::|:::         |...:|..:|:|   ..||.:...|:.....|...:::
Human  1847 NHVKKQSLLKSGFQVSQTTPQAKSGVKDDEI---ITTDSISVSPAPQHSGDERENYELPQGQSSK 1908

  Fly  1115 ----------FNCLSQQD-------------------QTRIIKEFGSAHL--------------- 1135
                      ....||::                   :|::.|| ||.:|
Human  1909 ESDKTLFKSSLKLFSQEESSVSMTANEKQSSGFLNLFKTQVNKE-GSPNLEKIGDTNVKIPPQEK 1972

  Fly  1136 --NQDPTNYLDYTSGTYSKA--PPEVLTHETNSSHLEFNHESESLFNSPNTSSYCKQKFVPGTSP 1196
              :...:|:.. |.|.:.||  .|...|..|:.|.:....|..|   ||.......|.  .|..|
Human  1973 KESSGVSNFWG-TLGDFFKANVSPIQTTENTSVSSMTIKDEVRS---SPTPMELASQG--AGNFP 2031

  Fly  1197 AKPSKVWKRLNTILADNLKLKRVSKFNRSLSLPGDVQSQGLQRQPRGQAGS------CPF----I 1251
            |.|          ::...| .||.:.|:..:    :....|:...||..|:      .||    |
Human  2032 AAP----------ISSKGK-ARVRRLNKQTT----IDDSRLEESTRGIQGNDLTEKEVPFRDHLI 2081

  Fly  1252 HKRSNLAGSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPDSAVSLDSAADKRFSSEKG------ 1310
            .:..|.:.|...|.:..::..:    ...||..|...|. .:.:|.|:.: ||.|:|:.
Human  2082 QQSPNSSFSTSSLKESSRESSV----ETSGVTTVTEVSK-SNEISFDTLS-KRNSNEQDHFSDKD 2140

  Fly  1311 ---------------LKKKTISSKMSGLMQKAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGN-- 1358
                           ..||:|.|.::|   ..|:..|.|..|.|..:.::....:|.|.|:.:
Human  2141 WSFSMAATSSSQPELSTKKSIFSFLTG---SEKSENRASATLPRAKSQAEGLFTLPSFFSTASSS 2202

  Fly  1359 ---------------------------------------------------DNSSISTRE----- 1367
                                                               ::.|..|||
Human  2203 IKKDASHSSSTFSFFSLSFLDQKKETSGEKQSISTVVPVTSQPCKKTNVFVESGSTMTRESSSGH 2267

  Fly  1368 -----------------ILLNQSIEVEDEQEDFNYKNRCDSK----SVLGGSIEKLNGNLTNNLF 1411
                             |.:|.:|||....::.:....|..|    .|.|.|::.....|..::.
Human  2268 RDSIAQEVVHEQQMAPCISINNTIEVTSLADELSVDKDCQEKLSSNIVPGTSVDFQMNELQKDII 2332

  Fly  1412 PIVGDLKK-----IQSPLPLAVLTEIPSYKDEYSNK---SDSIKNS------------------- 1449
            |...:.:.     :..|..|.:   .|..::.:::|   |||:.||
Human  2333 PPSPEFQAQAETFLTGPENLGI---APHEEEAFNHKAFPSDSLSNSFSHAKQLIEKFNDLDTCTN 2394

  Fly  1450 --------------PIE------MPKIL------LETACNQELNLAHSDDDVDKNILANS----- 1483
                          |:|      :|:||      .|..|...|....:|.:.||..|.:|
Human  2395 CHQNEKFTTDPVNLPLEKAPDEVLPQILEPASSSPEPGCAGNLQNQDADKEEDKFALGSSVDMLS 2459

  Fly  1484 -----AKDY----VNAPT-----------------FSILKTVEDASEPT--------MTPLHTTT 1514
                 .|.:    :..|.                 ||:...|  :|:|.        .:|.....
Human  2460 GFVTKVKSFSGSLIEPPKTLSGLFSSPKSPKKNSFFSLASDV--SSQPLKGELFGIFKSPKPEPY 2522

  Fly  1515 TTNSSLNVTSALWVTQQCLDLPNYPGWGS----REDDDNRSQHSARTLSSSR----RQSTEDSID 1571
            ...|||..||  |:...|    :....||    |.:....:..|..|||..|    ....|..|.
Human  2523 KQESSLPATS--WLQNGC----SRDAVGSVPPERREAAFTALSSESTLSDCRMTVVSAKPESDIL 2581

  Fly  1572 TDDEYFYYELRQ-------LEEQEKQRAHNSA---------IPSCERQNDNDVL----------- 1609
            |||.....::..       ||.|..:..:.|:         :.|...:.|..:|
Human  2582 TDDPKLTTKMEDNNTPENILEPQRSETINTSSFSGDDTGQGVLSLSDEGDMGILQATDTEASLEA 2646

  Fly  1610 --FSQIGQL--------------------------LQNDVNGGDGFRHSNGCNDGEDAIIF---S 1643
              |:...||                          :|......|........:...|.::|   |
Human  2647 ENFALPAQLHPDPTCIAEELPPPIQPPLPLEPEPAIQTASTNQDLLELHPASSLETDTMLFNDAS 2711

  Fly  1644 PSESVKLRMSEVF------------KELKSVVSLN-------------------PSVN------- 1670
            .|:|..|.....|            :|...::...                   |:|.
Human  2712 VSQSTTLETEGHFSHPLLEDPVLAARESCEIIHAQKDPPVVPQETEQSRPRFEIPNVTTWPKLRL 2776

  Fly  1671 -NDATFEGVPI------------------VKPTYEKLETVSDLHSAWQDVNGDLQIAASDIDSNE 1716
             :.||..|.|:                  :..:::||.|:.:..|     .|...:.|||.....
Human  2777 PSSATNHGKPLSSFFSSPLPSGNRAAETGLMSSFKKLSTLFEGSS-----EGKGSVLASDSKLGF 2836

  Fly  1717 DLVG--------NKG--RETPTYNKQRKLRRLKKKTRDRKINIS------KNATSSSSSCHSENE 1765
            ..|.        |||  .:.||.:....|    ..:.|:.:|.|      |::..|.:|......
Human  2837 GKVDLSFPWPKENKGVPEQMPTESSPPVL----VTSSDQDLNSSEANKALKSSQISGASAQPGKV 2897

  Fly  1766 CNTPLGQCTQKSVAEKD--------TNDISNKSEASSETSGPDTPAELSD------------VDI 1810
            ...|.| .:::.||..:        :.:..|:.|.|:.....||.|.||.            ..:
Human  2898 YTQPSG-TSEQLVASPEVCAQGLSGSGEGGNQQEISASGEHWDTKANLSSPACPSGKHEEEPSTV 2961

  Fly  1811 SETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQFDVDHSLINQ-PLETSQYNTHMLENITSAS 1874
            ||..:.|   :.|..:.:..::.|.|.|.:...|. |:...:.|: |..:|:|.:..  |::..|
Human  2962 SEIFHQL---EKQEEEAVPASTDSDLNVQQPVTLN-DIKEPMTNKSPTSSSRYGSSC--NVSQGS 3020

  Fly  1875 IPSQNRQID-----------SKTLMS-QSSHA---DGSQAVGNETAVGLSSSKWKLLKTLKERKI 1924
              ||..::|           :.::.| .|||:   ||....|.:.         |.|:...:.:.
Human  3021 --SQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQE---------KPLEVTGQAEK 3074

  Fly  1925 EEKNNQDKIKED-------EMIKDRD-----------KNGGGP------------GEVGLRTNGH 1959
            |......::|||       :::..:|           :|...|            .:|.|:....
Human  3075 EAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEI 3139

  Fly  1960 PGDNP--------------FYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAV-PRA 2009
            |.|..              .| .||||||:| |:|.:||||:|.|    ...|.||:|||: .|.
Human  3140 PDDGDPSLPQWLPEGPAGGLY-GIDSMPDLR-RKKPLPLVSDLSL----VQSRKAGITSAMATRT 3198

  Fly  2010 TLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVK 2074
            :|.||:||.|||||.|||||||||.||||||.:||||:||||||||||||||||||:||:|||||
Human  3199 SLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVK 3263

  Fly  2075 CHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKS 2139
            |||||:|||||||||||||||.||||||:..:||.|||||||.|||.||||||:||.||:|.:.:
Human  3264 CHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAA 3328

  Fly  2140 HAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELN 2204
            |...||.||||||||||||||||.|||:|||||.||||:|:|||||||||||.||||:|:...||
Human  3329 HVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLN 3393

  Fly  2205 PVWNEKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNL 2269
            |||.||||||||||||||||||||||:|:||:::|:|.|||||||||||||||||||||||||||
Human  3394 PVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNL 3458

  Fly  2270 EKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCE-ENTGMVKLPTQKGDDAW 2333
            |||||||||||||||.|||||||||||||||||||||||||||||.: :.:|.|::|..:|||||
Human  3459 EKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAW 3523

  Fly  2334 KLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASS 2398
            |:||||..:||||||:||||||:||||||||.|||:||:|||||||||||||||||||||||||:
Human  3524 KVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAST 3588

  Fly  2399 AVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFR 2463
            .|||||||||||||||:|||||||||||||||||.|||||||.|||:|.||||||||||||||||
Human  3589 NVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFR 3653

  Fly  2464 MKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDHEPKLDSVD 2528
            ||||||.||||||.||||||||||.|||:::|.||::||:|::|:   :.:..|::..|.:.::|
Human  3654 MKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQL---KQELPPEEQGPSIRNLD 3715

  Fly  2529 FWHKLIALIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSS 2593
            ||.|||.||||:|:||||||..||||||||||:|::||..||||||.||||||||||:..||||:
Human  3716 FWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSA 3780

  Fly  2594 AYMNLHFRVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGF 2658
            .||||||:||||::.||:::|..:|.||:||||||.||:|||:||:|||||:|.||.:|||||||
Human  3781 DYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGF 3845

  Fly  2659 QKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFP 2723
            |::|||||||.|||||||||.|.|:::.|||||||.|...|||||||||.|||:.||||:..:||
Human  3846 QQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFP 3910

  Fly  2724 EHMKDERIACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISL 2788
            .:...|::.||||||:||||||||||||:|||.:|:.:||:.|||||..||:.||:|:..|..|.
Human  3911 AYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSF 3975

  Fly  2789 EPRITQSVRELGDMLLSIKGGSGTLAAGNLAAQ-RNAVAVEADEVLRPLMDLLDGSLTLYAQSCE 2852
            :.||.:.||::.|:|..::|      .||.:.. |.:.|.:||.|||||||.|||:|||:|..||
Human  3976 QVRIDECVRQMADILGQVRG------TGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCE 4034

  Fly  2853 KTVLKRLLKELWKIVMRILEKTIVLPPMTDKT---MMFKHLTDNAKNLASNAKIEDMGRLFKSHM 2914
            ||||||:|||||::||..:|:.|||||:||:|   ::|    ..||.|:..:|::|       ||
Human  4035 KTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIF----TAAKELSHLSKLKD-------HM 4088

  Fly  2915 AGKQDVKSALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLR 2979
            .                :|..:||:||||||||:|||||||||||||||||||||||||:|||||
Human  4089 V----------------REETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLR 4137

  Fly  2980 YALSLYTQMTDTLIKTFISSQVHE---VDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAAN 3041
            ||||||||.||||||||:.||..:   ||     :.|||:|:|:|||:|||||||||.|||||||
Human  4138 YALSLYTQTTDTLIKTFVRSQTTQGSGVD-----DPVGEVSIQVDLFTHPGTGEHKVTVKVVAAN 4197

  Fly  3042 DLKWQIPSGMFRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHI 3106
            ||||| .:|||||||::.::|||..:|||||.||||||||:|||||:|.|.:||||..:.:||.|
Human  4198 DLKWQ-TAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQI 4261

  Fly  3107 CVKDYCFARDDRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEF 3171
            |||||||||:||::|:||:||:|::.|||.|||.||.|:|.|||||.|||||||||:|||||:||
Human  4262 CVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREF 4326

  Fly  3172 VKLKSEIR 3179
            ||||||.|
Human  4327 VKLKSESR 4334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	42/48 (88%)
		C2B_Munc13	2160..2286	CDD:175993	106/125 (85%)
		DUF1041	2477..2584	CDD:283860	65/106 (61%)
		Membr_traf_MHD	2832..2992	CDD:287505	97/162 (60%)
		C2C_Munc13	3032..3152	CDD:176041	81/119 (68%)
UNC13B	NP_001358118.1	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..210
		C1	3227..3276	CDD:237996	42/48 (88%)
		C2B_Munc13	3349..3475	CDD:175993	106/125 (85%)
		DUF1041	3667..3769	CDD:368829	63/104 (61%)
		Membr_traf_MHD	4014..4150	CDD:371123	97/162 (60%)
		C2C_Munc13	4188..4307	CDD:176041	81/119 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I912
eggNOG	1	0.900	-	-		E1_KOG1011
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001626
OrthoInspector	1	1.000	-	-		otm41575
orthoMCL	1	0.900	-	-		OOG6_103034
Panther	1	1.100	-	-	LDO	PTHR10480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10279
SonicParanoid	1	1.000	-	-		X1191
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.800