DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-13 and mctp2

DIOPT Version :9

Sequence 1:	NP_001245427.1	Gene:	unc-13 / 43841	FlyBaseID:	FBgn0025726	Length:	3186	Species:	Drosophila melanogaster
Sequence 2:	XP_031755096.1	Gene:	mctp2 / 100498038	XenbaseID:	XB-GENE-983153	Length:	899	Species:	Xenopus tropicalis

Alignment Length:	839	Identity:	167/839 - (19%)
Similarity:	285/839 - (33%)	Gaps:	272/839 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1533 LDLPNYPGWGSREDDDNRSQHSARTL--SSSRRQSTEDSIDTDDEYFYYELRQLEEQEKQRAHNS 1595
            :::..:..|.|.::       ..|.|  :.|.|:|.:.|:..|    ..:.|:|..:......|.
Frog     1 MEVDKHSVWDSLKE-------KTRPLIQNLSIRKSKKSSVKVD----ISKRRKLGHRMSLSVPNM 54

  Fly  1596 AIPSCERQNDNDVLFSQIGQLLQNDVNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELK 1660
            ....|..|.:||.:.:|:.....::       |||:       .::|..      |..|..|:.|
Frog    55 KEIGCTAQEENDFIETQVSACSVSN-------RHSS-------PMLFHS------RQREYVKQSK 99

  Fly  1661 SVVSLNPSVNNDATFEGVPIVKPTYEKLETVSDLHSAW-QDVNGDLQIAASDIDSNEDLVGNKGR 1724
                                        ||     |.| |:.:..::|..::.|..:.
Frog   100 ----------------------------ET-----STWVQEDSVHMEIIVTEYDDVDC------- 124

  Fly  1725 ETPTYNKQRKLRRLKKKTRDRKINISKNATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNK 1789
             :|:..|       |....|..:::            .:.||   ||........|:.:..|...
Frog   125 -SPSGPK-------KDTCEDNILDL------------LQKEC---LGDDPSDQKPEERSGSIDLN 166

  Fly  1790 SEASSETSGPDTPAELSDVDISETENGL----------RADDGQNIDNMRGNSGS-----LLKVN 1839
            |..:|:.|     ||||.::..|:.:.|          ...:|:|: .:|..||:     ..|:|
Frog   167 SSLASQLS-----AELSGLENYESLSTLPSLLSYLLTIHLKEGRNL-VIRDRSGTSDPYVKFKLN 225

  Fly  1840 RKYLLQFDVDHSLINQ--------PLETSQYNTHMLENITSASIPSQNRQIDSKTLMSQSSHADG 1896
            :|.|.:..|.:..:|.        |:::.....|         |...:|.:.:...|
Frog   226 KKTLYKSKVIYKNLNPVWDETFVLPIQSLDQKLH---------IKVYDRDLTTDDFM-------- 273

  Fly  1897 SQAVGNETAVGLSSSKWKLLKTLKERKIEEK----NNQDKIKEDE---------MIKDRDKNGGG 1948
                         .|.:..|:.|:..|..||    .:.:.::||.         .|:.||
Frog   274 -------------GSAFLELQDLELNKTTEKVFHLEDPNSLEEDMGIIMADVSLSIRRRD----- 320

  Fly  1949 PGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAVPRATLND 2013
            |.:.|..:....|        .|..|:..|.:   |..|.         ||:..:|::...:|..
Frog   321 PKDTGRSSRRRLG--------ASKTDLYRRNR---LWFEC---------RNSTFSSSLTTTSLQG 365

  Fly  2014 EDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQG-VRCTECGVKCHE 2077
                            .|::.:...| .||..|......|...|..|:.... ||......|...
Frog   366 ----------------VPVAESLRKN-QLWNGTVSITLLEGRNLSEGLTLDSFVRFKLGDQKYRS 413

  Fly  2078 K--CKDLLNADCLQRAAEKSSKHGAEDKANSIITAM--KDRMKQRERE---KPEIFEL-----IR 2130
            |  ||   :|:...|  |....|...||...:...:  ||..|..|..   |.:|..|     .|
Frog   414 KTLCK---SANPQWR--EHFDFHYFSDKMGILDIEVWGKDNRKHEELVGMCKVDIAGLPLQLNNR 473

  Fly  2131 AVFSVEEKSHAGHMKAVKQSVLDGTS--------------------KWSAK-----------IAI 2164
            .|..:|....:.|| .|..:..||.|                    :::.|           :.:
Frog   474 LVLPLENNQGSIHM-MVALTPCDGVSISDLCVCPLVDPAERMQINKRYNVKSSFQNLKDIGFLQV 537

  Fly  2165 TVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDE 2229
            .|:.|:.|:|.|.||.|||:..::|...:.:|.|:.:.|||.||:.|.|...:..|.:.|.|:||
Frog   538 KVLKAEDLLAADFSGKSDPFCVLEVGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLDVTVFDE 602

  Fly  2230 DNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISV 2288
            |.|           :..||||:..|.:.::.....|.|:|:.:...||..|.:.|.|.:
Frog   603 DGD-----------KPPDFLGKVAIPLLSVKPGQQVAYSLKNKDLGSASKGVLHLEIDL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-13	NP_001245427.1	C1	2038..2087	CDD:237996	14/51 (27%)
		C2B_Munc13	2160..2286	CDD:175993	40/136 (29%)
		DUF1041	2477..2584	CDD:283860
		Membr_traf_MHD	2832..2992	CDD:287505
		C2C_Munc13	3032..3152	CDD:176041
mctp2	XP_031755096.1	C2A_MCTP_PRT	198..315	CDD:176007	24/147 (16%)
		C2B_MCTP_PRT	382..493	CDD:176022	28/116 (24%)
		C2C_MCTP_PRT	533..651	CDD:176023	40/129 (31%)
		PRT_C	<782..>847	CDD:337028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D234298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920