DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-13 and LOC100489443

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:XP_031750829.1 Gene:LOC100489443 / 100489443 -ID:- Length:2023 Species:Xenopus tropicalis


Alignment Length:2208 Identity:1031/2208 - (46%)
Similarity:1325/2208 - (60%) Gaps:332/2208 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1083 KSEDQICRPCLTDK---LVFYPSSNSITDHNS-------SHD-FNC-LSQQDQTRIIKEFGSAHL 1135
            :|:.|....||.:|   |:..|......:|::       ..| |.| :.:.......|......|
 Frog    31 QSKRQKLALCLREKMKRLLQGPVDKISANHDNQIFPVEIDEDLFVCGIKRTPNIAFQKPVDDMEL 95

  Fly  1136 NQDPTNYLDYTSGTYSKAPPEVLT------HETNS-SHLEFN--HESESLFNSPNTSSYCKQKFV 1191
            .::|..    .:.|..:.|.|.||      .|.|| .|.|.|  :|.:|...||     |:...:
 Frog    96 KEEPKE----LNKTCVEGPDECLTPSLKLPDEQNSCDHDEGNSSNEEDSEVLSP-----CQSSGL 151

  Fly  1192 PG----TSPAKPSKVWKRL---NTILADNLKLKRVSKFNRSLSLPGDV------QSQGLQRQPRG 1243
            |.    .|....:..|:.:   |::...|:.|....:...|....|||      :.||:.|.   
 Frog   152 PSDKQDMSAISITMSWREISEHNSLFCPNIPLDPDRESTGSSDRSGDVVEYIIKELQGISRI--- 213

  Fly  1244 QAGSCPFIHKRSNLAGSPVQLSKRIQKLPIRFIGRAKGVPFVRRSSSPDSAVSLDSAADKRFSSE 1308
            ||.........|.:.||..::|..:..:.....|...||      .||.:|.|.:...|.:  :|
 Frog   214 QAEIAELRQHLSLIKGSVEEVSTCVDSVLNEIEGLQVGV------KSPGTASSAELYKDSQ--NE 270

  Fly  1309 K------GLKKKTISSKMSGLMQKAKTYKRHSFVLRRGC-NMSDSELEMPDFVSSGNDNSSI--- 1363
            :      |:.:....:.:..:         |.|:....| |...|:..:.|....||..|.:   
 Frog   271 ETVLYFYGVSEHEGENTLDAI---------HCFLSDHHCFNGVQSKEYIKDAYRLGNGASGLLDP 326

  Fly  1364 ----------STREILLNQSIEVEDEQ------EDFNY-----KNRCDSKSVLGGSIEKLNGNLT 1407
                      ..|:.:|..|:.::...      |:.|.     :||.:|.||       |...|.
 Frog   327 RPTVVRLAHREQRDFILQNSVRLQSAGVRIVPFEEHNIQGLQSRNRANSMSV-------LQQGLR 384

  Fly  1408 NNLFPIVGDLKKIQSPLPLAVLTEIPSYKDEYSNKSDSIKNSPIEMPKILLETACNQELNLAHSD 1472
            .|.:..|...|.:..|.......:..|::..|.|.|...:.:..|.......|.||....|..:.
 Frog   385 ENRWSSVSLDKGVVRPDDSGGDWKTESFRIRYKNSSTETQCAGEEFVFAQTSTKCNLTAELEATG 449

  Fly  1473 DDVDKNILANSAKDYVNAPTFSILKTVEDASEPTMTPLHTTTTTNSSLNVTSALWVTQQCLDLPN 1537
            ..|.:                     |::..|...:..|.....:|.        .:||.|.:.|
 Frog   450 SQVCQ---------------------VKENCELEKSVSHLCIRLDSQ--------ESQQNLHITN 485

  Fly  1538 YPGWGSREDDDNRSQHSARTLSSSRRQSTEDSIDTDDEYFYYELRQLEEQEKQRAHNSAIPSCER 1602
            .|     ...|..:...||.|:.|...|.....|              |.|      .||..|..
 Frog   486 KP-----SSMDKANCRCARLLTRSSHLSASSEAD--------------EAE------IAIQRCCS 525

  Fly  1603 QNDNDVLFSQIGQLLQNDVNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSE----VFKELK-SV 1662
            ..|                      .|:.|...||:.::...|.. |.|.:|    :.|:.. |.
 Frog   526 VVD----------------------EHTEGLIKGENELVSCDSRR-KFRSTEKINVIIKDPSGSF 567

  Fly  1663 VSLNPSVNNDATFEGVPIVKPTYEKLETVSDLHSAWQDVNGDL-QIAASDIDSNEDLVGNKGRET 1726
            .||:.....|...:|.     ..|.|:.|..:....||..|.: :...:..|.|.|:|..|    
 Frog   568 TSLSFDDTVDKRSDGT-----VAETLKEVVHIDLDTQDQTGHVFRDFLNQPDENIDIVDIK---- 623

  Fly  1727 PTYNKQRKLRRLKKKTRDRKINISKNATSSSSSCHSENECNTPLGQC-TQKSVAEKDTND-ISNK 1789
             .|  ..||.:.....|. .:.:..|...|........|...|:..| :..||.....|| |..:
 Frog   624 -FY--ANKLGKALNHFRS-ALKVVFNKLESPEVFMESKESGFPVHDCDSLASVGTGHFNDSIPTQ 684

  Fly  1790 SEASSETSGPDTPAELSDVDISETENGLRADDGQNIDNMRGNSGSLLKVNR-----------KYL 1843
            |..|:..|               :.:.|:.|             :...:||           ..:
 Frog   685 SSRSNSYS---------------SSSNLKED-------------AYFVLNRVSSLPHETSIPSLI 721

  Fly  1844 LQFDVDHSLIN--QPLETS---QYNTHMLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNE 1903
            |..|||   :|  |||..|   ..::.:.|.:..|. |.:..|:.::|:..       ::.:.| 
 Frog   722 LSPDVD---LNSAQPLSQSDETMESSELTEELKEAK-PMRLDQVCAETIYL-------NKCINN- 774

  Fly  1904 TAVGLSSSKWKLLKTLKE-RKIEEKNNQDKIKE------DEMIKDRDKNGGGPGEVGLRTNGHPG 1961
                       ....||| :|::.|..:|.::|      :||..:..:     .|...:.:|.|.
 Frog   775 -----------FKNVLKEKKKMQRKLLKDIVQETFWVSGEEMTSEESR-----AEYQTQDDGDPS 823

  Fly  1962 DNPFYS--------NIDSMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAV-PRATLNDEDLK 2017
            ..|::.        .||||||:| ::|.|||||:|.:..:.:  |.||::||: .|.:|.|||||
 Frog   824 KPPWFKGGPAGGLYGIDSMPDLR-KKKPIPLVSDLAMSLVQS--RKAGISSAMATRTSLKDEDLK 885

  Fly  2018 MHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDL 2082
            .|||||.|||||||||.||||||.:||||:||||||||||||||||||:||:||||||||||:||
 Frog   886 THVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDL 950

  Fly  2083 LNADCLQRAAEKSSKHGAEDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSHAGHMKAV 2147
            ||||||||||||||||||||:..:||.|||||||.|||.||||||:||.||.|.:.:||..||.|
 Frog   951 LNADCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFDVGKVAHAQQMKTV 1015

  Fly  2148 KQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFH 2212
            |||||||||||||||.|||:|||||.||||:|:|||||||||.|.||||:|:...|||||.||||
 Frog  1016 KQSVLDGTSKWSAKITITVLCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEEKFH 1080

  Fly  2213 FECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSA 2277
            ||||||||||||||||||:|:||:::|:|.|||||||||||||||||||||||||||||||||||
 Frog  1081 FECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSA 1145

  Fly  2278 VSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHYLCE-ENTGMVKLPTQKGDDAWKLYFDEIP 2341
            |||||||.|||||||||||||||:|||||||||||||.: :..|:||:|..|||||||:||||..
 Frog  1146 VSGAIRLQISVEIKGEEKVAPYHIQYTCLHENLFHYLTDVQGGGVVKIPEAKGDDAWKVYFDETA 1210

  Fly  2342 EEIVDEFSMRYGIENIYQAMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVSASDRF 2406
            :||||||:||||||:||||||||.|||:||:|||||||||||||||||||||||||:.|||||||
 Frog  1211 QEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRF 1275

  Fly  2407 AASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSS 2471
            :|||||||:||||||||||||||||||||||||||||::|.||||||||||||||||||||||.|
 Frog  1276 SASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPDRLQDLKSTVDLLTSITFFRMKVQELQS 1340

  Fly  2472 PPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRAPDDHE-PKLDSVDFWHKLIA 2535
            |||||.||:|||||||.|||:::|.||:|||:||:|.||.:.:..|.:.: |.:.::|||.|||.
 Frog  1341 PPRASQVVRDCVKACLNSTYEYIFNNCHELYSREYQADPTKKQDLPPEEQGPCIKNLDFWPKLIT 1405

  Fly  2536 LIVSVIDEDKNSYGTVLNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHF 2600
            ||||:|:||||:|..||.||||||::|::||..||:|||.|||||:||||:||:|||:.||||||
 Frog  1406 LIVSIIEEDKNAYTPVLKQFPQELSVGKVSAEVMWNLFAQDMKYAMEEHEKHRMCKSADYMNLHF 1470

  Fly  2601 RVKWLYSNYVKEVPPYKGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHA 2665
            :|||||:.||:::|..|..||:||||||.||||||:||::||:|:.:||.:||||||||::||||
 Frog  1471 KVKWLYNEYVRDLPAMKDKVPEYPAWFEQFVMQWLDENEEVSIEFQNGALERDKKDGFQQTSEHA 1535

  Fly  2666 LFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDER 2730
            |||.|||||||||.|.|:::.|||||||.|...|||||||||.|||:.|::||...|..:...|:
 Frog  1536 LFSCSVVDVFTQLNQSFEIIKKLECPDPVIVAHYMRRFAKTINKVLLQYSEIVAKSFQSYCFKEK 1600

  Fly  2731 IACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQS 2795
            :.||||||:||||||||||||:|||.:|:.:|::.|||||..||:.||:|::.|..|.:.||.:.
 Frog  1601 LPCILMNNVQQLRVQLEKMFEAMGGKELDPEASDTLKELQVKLNTVLDELSTVFGNSFQFRIDEC 1665

  Fly  2796 VRELGDMLLSIKGGSGTLAAGNLAAQ-RNAVAVEADEVLRPLMDLLDGSLTLYAQSCEKTVLKRL 2859
            ::::.::|..:||      .||:||. ||.||.:||.|||||||.|||:|||:|..||||||||:
 Frog  1666 IKQMAEILGHVKG------TGNVAANARNTVAQDADNVLRPLMDFLDGNLTLFATVCEKTVLKRV 1724

  Fly  2860 LKELWKIVMRILEKTIVLPPMTDKT---MMFKHLTDNAKNLASNAKIEDMGRLFKSHMAGKQDVK 2921
            |||||::||..:||.|||||:||::   |:|    ..||.|...:|::|       ||.      
 Frog  1725 LKELWRVVMNTMEKMIVLPPLTDQSGTQMIF----SAAKELGHLSKLKD-------HMV------ 1772

  Fly  2922 SALSGVMDISKEVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYT 2986
                      :|..::|:||||||:|:||||||||||||||||||||||||.|||||||||||||
 Frog  1773 ----------REETRSLTPKQCAVMDLALDTIKQYFHAGGNGLKKTFLEKSSELQSLRYALSLYT 1827

  Fly  2987 QMTDTLIKTFISSQVHEVDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGM 3051
            |.||||||||:.:|..:.  ...|:.|||:|:|:|||:||||||.||.|||||||||||| .:||
 Frog  1828 QTTDTLIKTFVQTQTSQG--SGVEDPVGEVSIQVDLFTHPGTGEQKVTVKVVAANDLKWQ-TTGM 1889

  Fly  3052 FRPFVDINLIGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARD 3116
            |||||::.:||||..:|||||.||||||||:|||||:|.|.:|||:..|.:||.:|||||||||:
 Frog  1890 FRPFVEVTMIGPHQSDKKRKFTTKSKSNNWAPKYNETFHFILGNEDGPDCYELQVCVKDYCFARE 1954

  Fly  3117 DRLVGVAVIPLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIR 3179
            ||::|:||:.|:||::|||.|||.||.|||.||:||.|:|||||||.|||||:|||||||:.|
 Frog  1955 DRVLGIAVMQLRDIADKGSCACWCPLGRRIHMDDTGLTVLRILSQRTNDEVAREFVKLKSDTR 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 42/48 (88%)
C2B_Munc13 2160..2286 CDD:175993 105/125 (84%)
DUF1041 2477..2584 CDD:283860 63/107 (59%)
Membr_traf_MHD 2832..2992 CDD:287505 96/162 (59%)
C2C_Munc13 3032..3152 CDD:176041 81/119 (68%)
LOC100489443XP_031750829.1 C1_Munc13-2-like 887..968 CDD:410409 72/80 (90%)
C2B_Munc13 1028..1154 CDD:175993 105/125 (84%)
DUF1041 1346..1454 CDD:399355 63/107 (59%)
Membr_traf_MHD 1696..1833 CDD:402254 96/163 (59%)
C2C_Munc13 1871..1990 CDD:176041 81/119 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 371 1.000 Domainoid score I888
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1567 1.000 Inparanoid score I91
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001626
OrthoInspector 1 1.000 - - otm48787
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1191
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.050

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