DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-13 and mctp1b

DIOPT Version :9

Sequence 1:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster
Sequence 2:XP_002663716.2 Gene:mctp1b / 100334264 ZFINID:ZDB-GENE-090313-382 Length:859 Species:Danio rerio


Alignment Length:1205 Identity:211/1205 - (17%)
Similarity:366/1205 - (30%) Gaps:496/1205 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1681 VKPTYEKLETVSDLHSAWQDVNGDLQIAASDIDSNEDLVGNKGRETPTYNKQRKLRRLKKKTRDR 1745
            |.|::::    .:....|:..:|..::..|      ..:..|.|      |...:.|:.||.||.
Zfish    10 VSPSHQQ----QNQRGLWKSFHGKSKLPGS------PKLSKKAR------KPESVFRIFKKKRDH 58

  Fly  1746 KINISKNATSSSSSCHS---------ENECNTP-LGQCTQKSVAEKDTNDISNKSEASSETSGPD 1800
              .:.:..:||..:.||         ...|.|| :..||..:.|                     
Zfish    59 --GLDRAVSSSQPNLHSAAADGEGSGRTRCGTPEMSACTAAAAA--------------------- 100

  Fly  1801 TPAELSDVDISETENGLRADDGQNIDNMRGNSGSLLKVNRKYLLQFDVDHSLINQPLETSQYNTH 1865
                              |..|..|..:: .|||              ....::|.|| |||.  
Zfish   101 ------------------ASLGAEIQMLK-RSGS--------------PKPTLSQLLE-SQYK-- 129

  Fly  1866 MLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAVGLSSSKWKLLKTLKERKIEEKNNQ 1930
                      |:.....|::|   .|....|.::||..|....:........||.:..|      
Zfish   130 ----------PASTCTDDAQT---HSDEEQGDKSVGVTTVAKGAVQPALPTSTLYQLDI------ 175

  Fly  1931 DKIKEDEMIKDRDKNGGGPGEVGLRTNGHPGDNPFYSNIDSMPDIRPRRKSI-PLVSELVLKTMA 1994
             .:|....:..||:.|.....|..:.   .|...|.|.|        .:|:: |:..|       
Zfish   176 -VLKRGNNLAIRDRAGTSDPYVKFKL---AGKEVFRSKI--------IQKNLNPVWDE------- 221

  Fly  1995 ATKRNAGLTSAVPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLW 2059
                         |..|..::||..:|.|     ::........:|:     ...|.|     |.
Zfish   222 -------------RVCLIVDNLKEPLYMK-----VFDYDFGLQDDFM-----GSAYLY-----LE 258

  Fly  2060 GIARQ---GVRCTECGVKCHEKCKDLLNADC-------LQRAAEKSSKHGAEDKANSIITAMKDR 2114
            .:.:|   .||.            ||.:..|       |:.......:..|:.:|     ..:.:
Zfish   259 SLEQQRPLDVRL------------DLQDPHCPDQDLGSLELTVTLYPRSPADREA-----LRQQQ 306

  Fly  2115 MKQREREKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSG 2179
            .:|.:::.|.:.:|              |.|         ...|...::|.:|..:.|||.|::|
Zfish   307 QQQMQQQSPRLSDL--------------HRK---------PQMWKGIVSIRLIEGRNLIAMDQNG 348

  Fly  2180 TSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRI-KVRVWDEDNDLKSKLRQKLTR 2243
            .|||||..::...|.:::|:|:.|||.|.|:|....::....| ::.|||:|           ..
Zfish   349 FSDPYVKFKLGPQKYKSKTIPKTLNPQWREQFDLHLYDEEGGILEISVWDKD-----------IG 402

  Fly  2244 ESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHE 2308
            ..|||:||.         |:::|....::|.|      :.||:                      
Zfish   403 RRDDFIGQC---------ELELWKLSREKTHK------LELHL---------------------- 430

  Fly  2309 NLFHYLCEENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQAMTHFHCLSAKYLC 2373
                   ||:.|.:                                                   
Zfish   431 -------EEDKGTL--------------------------------------------------- 437

  Fly  2374 PGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLD----QLHNSLRIDLSMY 2434
                .|:.||           ||::.||.||          ..|.|||    :.|.|.|.     
Zfish   438 ----VVLVTL-----------TATATVSISD----------LSVNLLDDPDQRQHISRRY----- 472

  Fly  2435 RNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKD---CVKACLRSTYQFLFE 2496
                   ||     |||..: |..:...::|:........|....|.   |:.            
Zfish   473 -------SP-----LKSFFN-LKDVGILQVKILRAEGLMAADVTGKSDPFCIA------------ 512

  Fly  2497 NCYELYNREFQVDPNEAKRAPDDHEPKLDSVDFWHKLIA---------LIVSVIDEDKNSYGTVL 2552
               ||.|...|.........|:           |:|:.:         |.:||.|||::.....|
Zfish   513 ---ELCNDRLQTHTVYKTLNPE-----------WNKVFSFNVKDIHSVLEISVYDEDRDRSADFL 563

  Fly  2553 NQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVP-PY 2616
                     |:::...:                  .:|.|.       :..::..|  ||:. |.
Zfish   564 ---------GKVAIPLL------------------NICSSQ-------QKAYVLKN--KELTGPT 592

  Fly  2617 KG-----------AVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNS 2670
            ||           ||......|.|...:::.|...||.:.|...|.|.|:        ..||   
Zfish   593 KGVILLQADVIFNAVRASLRTFVPAEQKYIEEEAKVSKQLLQQNFNRVKR--------CVLF--- 646

  Fly  2671 VVDVFTQLTQCFDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEHMKDERIACIL 2735
            :::|...:..||.            |:...|.....::.|::.:      .|..:|....:..:|
Zfish   647 LINVGYYINSCFQ------------WESPRRSLCAFLIFVVVVW------NFEIYMLPLSLLLLL 693

  Fly  2736 M--------------NNIQQLRVQLEKMFESMGGDKLEEDAAN--------ILKELQQNLNSALD 2778
            :              .|::.:...||.:.|.  .||.::|:..        .::::...:.:|||
Zfish   694 IWNYLRKASGKGTCEGNVEVMEDLLEDVDED--SDKEDKDSEKKGFLDKFYAIQDVIITVQTALD 756

  Fly  2779 DLASQFAISLEPRITQSVRELGDMLLSIKGGSGTL 2813
            ::|| |...::.....||..|..:.:::.....|:
Zfish   757 EVAS-FGERVKNTFNWSVPFLSWLAITVLCAGATI 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 9/51 (18%)
C2B_Munc13 2160..2286 CDD:175993 36/126 (29%)
DUF1041 2477..2584 CDD:283860 17/118 (14%)
Membr_traf_MHD 2832..2992 CDD:287505
C2C_Munc13 3032..3152 CDD:176041
mctp1bXP_002663716.2 C2A_MCTP_PRT 172..293 CDD:176007 30/185 (16%)
C2B_MCTP_PRT 330..445 CDD:176022 43/235 (18%)
C2C_MCTP_PRT 485..603 CDD:176023 27/179 (15%)
PRT_C <751..>804 CDD:285560 10/41 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D234298at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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