Protein Alignment eIF4G1 and EIF4G3

DIOPT Version :9

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: XP_011540672.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1678
• Species: Homo sapiens
• Alignment Length: 1862
• Identity: 461/1862 - (24%)
• Similarity: 734/1862 - (39%)
• Gaps: 526/1862 - (28%)

  Fly   304 PPSTPNAPRGASG-----GATRHV----HVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYA 359
            |.|:|:...||..     .|.:|:    |:...|..|......:.||....|.....|..:....
Human    81 PNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQP 145

  Fly   360 PAPMPYYQ---------------------YQ----YVPTLQQQPPHTRSAVTVN-TNVNVGNN-- 396
            |.|.|:|.                     ||    .|||.||.||..|...|:. .:.|.|..
Human   146 PGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDI 210

  Fly   397 LQPVQSG-----PNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVM 456
            .:.:.||     |..|:..|.::.:..|.|.|.| |..|.|  |.|...:.......|:......
Human   211 TEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQV-PEHSPV--VYGTVESAHLAASTPVTAASDQ 272

  Fly   457 TTSVQPQPVQVQPASRRRHQHRLQIIDPTTK------KNILDDFDKTKSNTDNEFSDQVTSTNTP 515
            ....:|:|                  ||..|      :.:|....|.:....:|.:..|:....|
Human   273 KQEEKPKP------------------DPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELP 319

  Fly   516 ATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPIS--------RTDVGPTPIV 572
               |...|..:   .||..:.:.:.:|....|:      ||.||.|.        |.|..|.|.:
Human   320 ---LPPSPTTV---SSVARSTIAAPTSSALSSQ------PIFTTAIDDRCELSSPREDTIPIPSL 372

  Fly   573 SAMTDAPSVEILPTPQRGRS--KK--------IPIVSPKNV-------------SESI------- 607
            ::.|:  :.:.|||.:....  ||        ||:||..|:             :|||
Human   373 TSCTE--TSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQE 435

  Fly   608 VAPITDETD-----------DAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDA 661
            |.|:|.|.:           :....||:.:|..|.||....|
Human   436 VLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTP----------------------- 477

  Fly   662 PTGLKEMHVAELESSVASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNA---VSPI 723
                           .||..|                    .|.|....|.:.:||:|   |..:
Human   478 ---------------PASPPH--------------------TPVIVPAAATTVSSPSAAITVQRV 507

  Fly   724 LHE--------VLDNTELSKKLE---NSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQD 777
            |.|        ..|..|:..|:|   :..||...|||:        |:.|.:....:|:.
Human   508 LEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQN--------LNSRRSPVPAQIAI----- 559

  Fly   778 VNSLDNNQIEKTYPSKPKLNVDVSEDISSRESAIKSTSTKNTGVDVGLQSD-SKPETTLNDKQDS 841
                   .:.||: .|||.....:|::...|..:|  :.:...:|..|:|: .|.....:.::|.
Human   560 -------TVPKTW-KKPKDRTRTTEEMLEAELELK--AEEELSIDKVLESEQDKMSQGFHPERDP 614

  Fly   842 TDLKVKVSAKISSI----------------------INYNEG----------------QWSPNNP 868
            :|||     |:.::                      |:.|.|                .|.|.:.
Human   615 SDLK-----KVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDT 674

  Fly   869 SGKKQYDREQLLQLREVKASRIQPE----VKNV-----------------SILPQ-PNLMPSFI- 910
            .||||||||.||..:.:.|...:||    :.:|                 .|||: |:..|:|.
Human   675 EGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFAD 739

  Fly   911 --RNNNNNK-----RVQSMVG--IIGNRSNESAGNYIGKQMSMSGVQSG----GGRSSMKGMIH- 961
              |.....:     :|||..|  |:......:....:.....|..:..|    |.|.|..|...
Human   740 FGRQTPGGRGVPICKVQSRHGLPILEQSKAPTCPPLVMSHPPMKSLPLGLLNVGSRRSQPGQRRE 804

  Fly   962 ----VNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLV 1022
                :.:|:.:||.|.:.||||:|.  .|.|..:|....::..||.|:||.|||||||:.|:.|:
Human   805 PRKIITVSVKEDVHLKKAENAWKPS--QKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLM 867

  Fly  1023 EEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAA-EVKVIDERMESETKSNSAHF 1086
            :::..|.:||.:::..||.||||||||||:|||:||.:|:.|.. :|.:.|:      ..|:.:|
Human   868 KQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADK------PGNTVNF 926

  Fly  1087 RNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVR 1151
            |..||::.::||.::.:.....|||.:    :::..:...|:..|...|||.:.|.||||.|.::
Human   927 RKLLLNRCQKEFEKDKADDDVFEKKQK----ELEAASAPEERTRLHDELEEAKDKARRRSIGNIK 987

  Fly  1152 FIGELFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKS 1216
            |||||||:.|||..|::.|:..||..|.|:.|||||:||||:|          ||    ...||:
Human   988 FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIG----------KD----LDFEKA 1038

  Fly  1217 ITRMQAIASKTDK--DGARVSSRVRFMLQDVIDLRKNKWQTSR-NEAPKTMGQIEKEAK----NE 1274
            ..||....::.:|  ...:.|||:|||||||||||...|.:.| ::.|||:.||.||||    .|
Human  1039 KPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEE 1103

  Fly  1275 QLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGG 1339
            |...|...|.....||                              .||.|.|.
Human  1104 QRKVQQLMTKEKRRPG------------------------------VQRVDEGG----------- 1127

  Fly  1340 NVSGGAGHSNGNNDENTWH-VQTSKGSRSLAVDSNKLEGLSKLS-DQNLETKKMGGLTQFIW--- 1399
                             |: ||.:|.||.|  |.:|...::|.: |:.::......|..  |
Human  1128 -----------------WNTVQGAKNSRVL--DPSKFLKITKPTIDEKIQLVPKAQLGS--WGKG 1171

  Fly  1400 -----ISSDTTRLSSA------------PTP---TPSNPFAVLSSLIDKNSNERDRDRSGPRNKG 1444
                 .:|:|..|.|:            |.|   |||.|.            |.|..|:
Human  1172 SSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPV------------EFDSRRT------ 1218

  Fly  1445 SYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHT 1509
            ..::|||.|::.|:.:.|.|     :|.|:..||| ..:.||.:..|:        :|......|
Human  1219 LTSRGSMGREKNDKPLPSAT-----ARPNTFMRGG-SSKDLLDNQSQE--------EQRREMLET 1269

  Fly  1510 VKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEA------SETDL-KLIKSVVS 1567
            ||  ...|..:|        ....|.|..::|..|..|....:.|      ||.:| :..||::.
Human  1270 VK--QLTGGVDV--------ERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIID 1324

  Fly  1568 EIVDLSAASKEVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQ--------YRRYLSIAV 1624
            |.:.::...:     |:.|:    |:|....:.::      ...||.:        .|.::...:
Human  1325 EFLHINDFKE-----AMQCV----EELNAQGLLHV------FVRVGVESTLERSQITRDHMGQLL 1374

  Fly  1625 SQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKEN 1689
            .||:|...:|.......::|....|:|:.:|||.:|||:.:...|::.:..:::.:|.....|..
Human  1375 YQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPL 1439

  Fly  1690 SPSNVAKKFLKTYL-IYCTQ----EVGPNFARNMWIKFNLKWSDFMPESE-VADFIKFNRLEYVE 1748
            .|...|...|...| :.|.|    :||.     :|.:.:|.|.||:||.| |.:|:...:|:::|
Human  1440 LPVGRAGVLLSEILHLLCKQMSHKKVGA-----LWREADLSWKDFLPEGEDVHNFLLEQKLDFIE 1499

  Fly  1749 NES--KSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGN---IMVVDKLFIRGLTET 1808
            ::|  .|..:..:|...:.:...::.:  ::::....:.|.|:...|   |.:....|:|.|...
Human  1500 SDSPCSSEALSKKELSAEELYKRLEKL--IIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTA 1562

  Fly  1809 LSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIG 1873
            :...:|....:::::::... |..:|:|.:|:||:.:.:|:.||.||..:..|:.|..||.....
Human  1563 VCKAAIIADSSTFRVDTAVI-KQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFD 1626

  Fly  1874 ELYDAFVIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            .|||..||.:::..||..|||  :..|||||:||:..||..|
Human  1627 CLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWL 1668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	104/250 (42%)
		MA3	1562..1677	CDD:280933	24/122 (20%)
		W2_eIF4G1_like	1764..1895	CDD:211397	33/135 (24%)
EIF4G3	XP_011540672.1	MIF4G	848..1076	CDD:280935	104/251 (41%)
		MA3	1315..1427	CDD:280933	25/126 (20%)
		W2_eIF4G1_like	1521..1649	CDD:211397	33/130 (25%)
		W2	<1628..1674	CDD:302589	20/41 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3681
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2257
Isobase	1	0.950	-	0	Normalized mean entropy	S5732
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm41681
orthoMCL	1	0.900	-	-		OOG6_101572
Panther	1	1.100	-	-	LDO	PTHR23253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R596
SonicParanoid	1	1.000	-	-		X1015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.850