Protein Alignment eIF4G1 and TIF4631

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: NP_011678.3
• Gene: TIF4631 / 853071
• SGDID: S000003394
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 984
• Identity: 233/984 - (23%)
• Similarity: 395/984 - (40%)
• Gaps: 233/984 - (23%)

  Fly   484 PTTKKNILDDFDKTKSNTDNEFSDQ---VTSTNTPATVLSEGPIRI--PQQESVG------LNNL 537
            ||...:..:.....::..|.:.|.|   .|:.|..:....:.|...  |.|:..|      .||.
Yeast     8 PTQSASKQESAALKQTGDDQQESQQQRGYTNYNNGSNYTQKKPYNSNRPHQQRGGKFGPNRYNNR 72

  Fly   538 TSTSSQGS-------ESRTNAP-----------YIPIETTPISRTDVGPTPIVSAMTDAPSVEIL 584
            .:.:..||       .:.:|.|           |.|.:..........|.|:.........:||
Yeast    73 GNYNGGGSFRGGHMGANSSNVPWTGYYNNYPVYYQPQQMAAAGSAPANPIPVEEKSPVPTKIEI- 136

  Fly   585 PTPQRG-------------RSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMPPNQT 636
             |.:.|             :|::...|||:  .||.:...:|.|..:..|| :.:|.:|...::.
Yeast   137 -TTKSGEHLDLKEQHKAKLQSQERSTVSPQ--PESKLKETSDSTSTSTPTP-TPSTNDSKASSEE 197

  Fly   637 HPNLLISDSSK-HKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAGILDVNV--------- 691
            :    ||::.| .:..:...::.|.|   |::....:||.|..:.|.|......||
Yeast   198 N----ISEAEKTRRNFIEQVKLRKAA---LEKKRKEQLEGSSGNNNIPMKTTPENVEEKGSDKPE 255

  Fly   692 --NKSSQSLDFSADPEI-----------DSIGAISPTSPNAVSPILHEVLDNTELSKKLENSTTE 743
              .|:..:.:.||:||:           ...|.|...|    :|.:....:..:| ||.:....|
Yeast   256 VTEKTKPAEEKSAEPEVKQETPAEEGEQGEKGQIKEES----TPKVLTFAERLKL-KKQQKEREE 315

  Fly   744 RFKDSQSVEKPTHQEL--SLRNA--------TDETEISAMALQDVNSLDNNQIEKTYPSKPKLNV 798
            :.:..::.|.|..:|.  ::.:|        .:|||:   |..:.:::|.:......|:|
Yeast   316 KTEGKENKEVPVQEETKSAIESAPVPPSEQVKEETEV---AETEQSNIDESATTPAIPTK----- 372

  Fly   799 DVSEDISSRESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTD-----LKV-KVSAKISSI-- 855
                  |....|.......:.|..:||:::.  |||.::..|.|:     |.| |.:..|..:
Yeast   373 ------SDEAEAEVEAEAGDAGTKIGLEAEI--ETTTDETDDGTNTVSHILNVLKDATPIEDVFS 429

  Fly   856 INYNEGQWSPNNPSGKKQ----YDREQLLQLRE---VKASR--IQPEVKNVSILP---QPNLMPS 908
            .||.||...|:....|:.    |....|||.::   |||..  :|.....:.|.|   :.|....
Yeast   430 FNYPEGIEGPDIKYKKEHVKYTYGPTFLLQFKDKLNVKADAEWVQSTASKIVIPPGMGRGNRSRD 494

  Fly   909 FIRNNNNNKR--------VQSMVGIIGNRSN-ESAGNYIGKQMS---MSGVQSGGGRSSMKGMIH 961
            ..|..||:.|        |::|    .:|:| .::.....|:|:   .|.......|...:|. :
Yeast   495 SGRFGNNSSRGHDFRNTSVRNM----DDRANSRTSSKRRSKRMNDDRRSNRSYTSRRDRERGS-Y 554

  Fly   962 VNLSLNQDVKLSE-------NENAWRPRVLNKS-------DGDSDAKSALEKDELVRRVRGILNK 1012
            .|....:|.|..|       :.|.|.|:..:|.       ||.::   .|:|||:.|:::.:|||
Yeast   555 RNEEKREDDKPKEEVAPLVPSANRWVPKFKSKKTEKKLAPDGKTE---LLDKDEVERKMKSLLNK 616

  Fly  1013 LTPERFDTLVEEI-----IKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVK--V 1070
            ||.|.||.:..||     |.:.....:.:..||..:|.||.|||::|..||:||.::..|:.  :
Yeast   617 LTLEMFDAISSEILAIANISVWETNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDI 681

  Fly  1071 IDERMESETKSNSA-HFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAF 1134
            .||..|.:|..... |:   |:.:...||.:..:             ||:....|.   ..||..
Yeast   682 TDETNEGKTGPKLVLHY---LVARCHAEFDKGWT-------------DKLPTNEDG---TPLEPE 727

  Fly  1135 LEEEE----RKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLL----NPHSEDMLECLCKLLT 1191
            :..||    ...:||..|.|||||.|:::::||||:::.|...|:    :..||:.||.:.:||.
Yeast   728 MMSEEYYAAASAKRRGLGLVRFIGFLYRLNLLTGKMMFECFRRLMKDLTDSPSEETLESVVELLN 792

  Fly  1192 TVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDK--DGARVSSRVRFMLQDVIDLRKNK-W 1253
            |||.:||.....:...    :||.| ..:.::....|.  ..|::|||::|.|.|:.:||.:| |
Yeast   793 TVGEQFETDSFRTGQA----TLEGS-QLLDSLFGILDNIIQTAKISSRIKFKLIDIKELRHDKNW 852

  Fly  1254 QTSRNE-APKTMGQI-EKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAY 1316
            .:.:.: .|||:.|| |:|.:..||                     |.:.|.|||...:.|:
Yeast   853 NSDKKDNGPKTIQQIHEEEERQRQL---------------------KNNSRSNSRRTNNSSN--- 893

  Fly  1317 GGSHSQRGD 1325
              .||.|.|
Yeast   894 --RHSFRRD 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830
		YppG	322..>379	CDD:372950
		MIF4G	1004..1252	CDD:397130	80/265 (30%)
		MA3	1562..1677	CDD:397128
		W2_eIF4G1_like	1764..1895	CDD:211397
TIF4631	NP_011678.3	PTZ00121	<133..362	CDD:173412	50/248 (20%)
		eIF_4G1	411..469	CDD:432365	16/57 (28%)
		SF-CC1	489..>562	CDD:273721	15/77 (19%)
		MIF4G	607..850	CDD:397130	80/266 (30%)