DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and TIF4632

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	NP_011466.1	Gene:	TIF4632 / 852833	SGDID:	S000003017	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	1198	Identity:	268/1198 - (22%)
Similarity:	440/1198 - (36%)	Gaps:	383/1198 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 HEKNIVGVSVNCVNTSKKYDFNNSSLLS------NNSYPASTAEYVSTGNNNSGNTRSNPQSGGI 300
            |:....|     .|.|:..:..|.:|.|      |..|.:...:|.:...||..|::.|.|
Yeast    24 HDNQYSG-----ANNSQPNNHYNENLYSAREPHNNKQYQSKNGKYGTNKYNNRNNSQGNAQ---- 79

  Fly   301 FRGPPSTPNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQ---QTFPASHLQYAPAP 362
                                      .|:...:....|.. ..|||..   ..:||::  ||| .
Yeast    80 --------------------------YYNNRFNNGYRLNN-NDYNPAMLPGMQWPANY--YAP-Q 114

  Fly   363 MPYYQYQYVPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQP 427
            |.|...|.||.  ..||:|.               ||:.:.|..| ..|  .:::|::.|.|.:
Yeast   115 MYYIPQQMVPV--ASPPYTH---------------QPLNTNPEPP-STP--KTTKIEITTKTGE- 158

  Fly   428 GASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASRRRHQHRLQIIDPTTKKNILD 492
                                                              ||.:      |...:
Yeast   159 --------------------------------------------------RLNL------KKFHE 167

  Fly   493 DFDKTKSNTDNEFSDQVTSTNTP----ATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRT-NAP 552
            :...:|....|:..:|.:.:.||    ||     |: :|..|:| .:.||.||::.|.|.. |..
Yeast   168 EKKASKGEEKNDGVEQKSKSGTPFEKEAT-----PV-LPANEAV-KDTLTETSNEKSTSEAENTK 225

  Fly   553 YIPIETTPISRTDVGPTPIVSAMTDAPSVEILPTPQRGRSKKIPIVSPKN--VSESIVAPITDET 615
            .:.:|..                               |.:|..:...||  :||:
Yeast   226 RLFLEQV-------------------------------RLRKAAMERKKNGLISET--------- 250

  Fly   616 DDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELE----SS 676
                         |.......|.|   :|::| ..:|..||..|:||....|.:...::    :|
Yeast   251 -------------EKKQETSNHDN---TDTTK-PNSVIESEPIKEAPKPTGEANEVVIDGKSGAS 298

  Fly   677 VASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLDNTELSKKLENST 741
            |.:..|..|.:       ::|:.|: :||.:|       |...|..::.:. |.||:|......|
Yeast   299 VKTPQHVTGSV-------TKSVTFN-EPENES-------SSQDVDELVKDD-DTTEISDTTGGKT 347

  Fly   742 TERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVNSLDNNQIEKTYPSKPKLNVDVSEDISS 806
            ..:                   :.|||         :||:                      |::
Yeast   348 VNK-------------------SDDET---------INSV----------------------ITT 362

  Fly   807 RESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINYNEGQWSPN----N 867
            .|:.:|.|....:  |:.:.:.|:...||...|..:|:..         ..|.|....|:    .
Yeast   363 EENTVKETEPSTS--DIEMPTVSQLLETLGKAQPISDIYE---------FAYPENVERPDIKYKK 416

  Fly   868 PSGKKQYDREQLLQLREVKASRIQPE-VKNVS---ILPQPNLMPSFIRNNNNNK-------RVQS 921
            ||.|..|....|||.::....|..|. |:.||   ::|     |...||...:.       |..|
Yeast   417 PSVKYTYGPTFLLQFKDKLKFRPDPAWVEAVSSKIVIP-----PHIARNKPKDSGRFGGDFRSPS 476

  Fly   922 MVGIIGNRSNESAGNYIGKQM-----SMSGVQSGGGRSSMKGMIHVNLSLNQDVKLSENENAWRP 981
            |.|:....|:..:.....|:|     |..|..|...|..............:...|..:.|.|.|
Yeast   477 MRGMDHTSSSRVSSKRRSKRMGDDRRSNRGYTSRKDREKAAEKAEEQAPKEEIAPLVPSANRWIP 541

  Fly   982 RVLNKSDGDS---DAKSAL-EKDELVRRVRGILNKLTPERFDTLVEEIIKLK-----IDTPDKVD 1037
            :...|.....   |.|:.| :|:|:.|:::.:|||||.|.||::..||:.:.     .|..:.:.
Yeast   542 KSRVKKTEKKLAPDGKTELFDKEEVERKMKSLLNKLTLEMFDSISSEILDIANQSKWEDDGETLK 606

  Fly  1038 EVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERM---ESETKSNSAHFRNALLDKTEQEFT 1099
            .||..:|.||.|||::|..||:||.::   ||.:|..:   |:|.|:......:.|:.:..:||.
Yeast   607 IVIEQIFHKACDEPHWSSMYAQLCGKV---VKDLDPNIKDKENEGKNGPKLVLHYLVARCHEEFE 668

  Fly  1100 QNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKI----RRRSGGTVRFIGELFKIS 1160
            :..:             ||:....|.|   .||..:..:|..|    :||..|.|||||.|:.::
Yeast   669 KGWA-------------DKLPAGEDGN---PLEPEMMSDEYYIAAAAKRRGLGLVRFIGYLYCLN 717

  Fly  1161 MLTGKIIYSCIDTLL----NPHSEDMLECLCKLLTTVGAKFEK----TPVNSKDPSRCYSLEKSI 1217
            :||||:::.|...|:    |..||:.||.:.:||.|||.:||.    ||..:.:.|  ..|:...
Yeast   718 LLTGKMMFECFRRLMKDLNNDPSEETLESVIELLNTVGEQFEHDKFVTPQATLEGS--VLLDNLF 780

  Fly  1218 TRMQAIASKTDKDGARVSSRVRFMLQDVIDLRKNK-WQTSRNEA-PKTMGQIEKEAKNEQLSAQY 1280
            ..:|.|.     ||..:|:|::|.|.||.:||:.| |.:::.:| |||:.||.:|  .|||..:
Yeast   781 MLLQHII-----DGGTISNRIKFKLIDVKELREIKHWNSAKKDAGPKTIQQIHQE--EEQLRQK- 837

  Fly  1281 FGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGA 1345
                             |...|.|||:.....|::...|.::|    |:::.|:::.....:|
Yeast   838 -----------------KNSQRSNSRFNNHNQSNSNRYSSNRR----NMQNTQRDSFASTKTG-- 879

  Fly  1346 GHSNGNNDENTWHV-QTSKGSRSLAVDS 1372
              |..||..|...| :.|:..|:...|:
Yeast   880 --SFRNNQRNARKVEEVSQAPRANMFDA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	85/267 (32%)
		MA3	1562..1677	CDD:280933
		W2_eIF4G1_like	1764..1895	CDD:211397
TIF4632	NP_011466.1	eIF_4G1	381..440	CDD:403394	16/67 (24%)
TIF4632	NP_011466.1	MIF4G	567..808	CDD:397130	84/266 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I1435
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9230
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R596
SonicParanoid	1	1.000	-	-		X1015
TreeFam	0	0.000	Not matched by this tool.
	7	6.940