Protein Alignment eIF4G1 and EIF4G

DIOPT Version :9

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: NP_001078319.1
• Gene: EIF4G / 825194
• AraportID: AT3G60240
• Length: 1727
• Species: Arabidopsis thaliana
• Alignment Length: 1909
• Identity: 397/1909 - (20%)
• Similarity: 694/1909 - (36%)
• Gaps: 547/1909 - (28%)

  Fly    42 PTSKPQSLHQPLQPQHSHPTAQPQFQINKAYNVVSILKASA----------QIAQQSPHL----T 92
            ||:..:|.::...|....||:|.....:|.....:..|.:|          |.....|.|    .
plant   113 PTNPTESFNRNTGPIPKAPTSQSTVMSSKINETPNTAKVAASGDASQAFPLQFGSLGPDLMVPAR 177

  Fly    93 NQQHPPIHHPQQTQQHQQSYTNVVNRSLSASEPVRAQSSVICNGSSILTVNSRQLNSGDMNSTAI 157
            ....||....|:..|.|||.....: ::.||.|.:..|                 |.|..|
plant   178 TTSAPPNMDDQKRAQMQQSSLRTAS-NVPASVPKKDSS-----------------NKGADN---- 220

  Fly   158 YNISSYRKLTGSLDGNVCFLNVQDIKQNGNISGSVVSNKSIVGVG----SEKSSCTGVSINNQIV 218
                                  |.:::.|:...|..::..:..:.    ::||..|.:.
plant   221 ----------------------QLMRKEGHNPSSEKADIQVPHIAPPSQTQKSPITNIR------ 257

  Fly   219 LPNAQIGTSMGIAGTTTAGTSYMHEKNIVGVSVNCVN--TSKKYDFNNSSLLSNNSYPASTAEYV 281
            :|:.|         |....|...|..:..|.:::...  |:..:.......||..:.|....:..
plant   258 MPSVQ---------TPYQHTQVPHPVHFGGPNMHMQTPVTATSFQMPMPMALSMGNTPQIPPQVF 313

  Fly   282 STGN-----NNSG--------------NTRSNPQSGGIFRG-PPSTPNAPRGASGGATRHVHVQP 326
            ..|:     ::.|              ..:.:||.|.:..| .|..|....|..|||.:...|:.
plant   314 YQGHPPHPMHHQGMMHQAQGHGFATPMGAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKI 378

  Fly   327 MYSQPLHQNMVLQQ----YTQ---------YNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQP 378
            .:.. .|:.:.|.:    |::         .||..::.|.|  .:||.|:...|..|.......|
plant   379 THPD-THEELRLDRRGDPYSEGDSTALKPHSNPPPRSQPVS--SFAPRPVNLVQPSYNSNTMIYP 440

  Fly   379 PHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMG 443
            |     |:|..|              |||:     ||:|.......|..|:..|..:..|..|..
plant   441 P-----VSVPLN--------------NGPM-----SSAQAPRYHYPVIDGSQRVQLINQPAHTAP 481

  Fly   444 QVGVP--PMVGVGVMTTSVQPQ--------------PVQVQPASRRRHQHRLQIIDPTTKKNILD 492
            |:..|  |.......|:||:.:              .|.|:||                  .:.:
plant   482 QLIRPAAPAHLSSDSTSSVKARNAQNVMSSALPVNAKVSVKPA------------------GVSE 528

  Fly   493 DFDKTKSNTDNEFSDQVTSTNTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIE 557
            .....|..:..|.:..::..|..|..||..    .|.:...::.:.::|:..::|       |:|
plant   529 KLGSPKDRSHGEVNISLSQKNVEACSLSSS----QQPKPSFVSGVPNSSAPPAKS-------PVE 582

  Fly   558 TTPISRTDVGPTPIVSAMTDAPSVEILP--TPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGS 620
            |.|::::.|...|.|.:     |||..|  |.:..|::.        |||||  .:.|:|  ...
plant   583 TVPLAKSSVETVPPVKS-----SVETAPVTTTEIRRAEM--------VSESI--SVEDQT--CKV 630

  Fly   621 TPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAG 685
            .|....||..   .||.|:.|:||......| :...:|..|..|.::.   .|:.|..|:...:.
plant   631 EPPHNLTENR---GQTMPDSLVSDPETATVA-AKENLSLPATNGFRKQ---LLKVSTTSDAPTSD 688

  Fly   686 ILDVNVNKSS---------------QSLDFSAD-----PEIDSIGAISPTSPNAVSPILHE---- 726
            .:|.:::||:               |..|...|     .::|....||......:|.:|.:
plant   689 SVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERSVISDAKHETLSGVLEKAQNE 753

  Fly   727 ---------------VLDNTELSKKLENST-----------TERFKDSQSVEKPTHQELSLRNAT 765
                           |.|:|  |..|.:||           :|..|  .:||..|.:..|.:...
plant   754 VDGATDVCPVSEKLAVTDDT--SSDLPHSTHVLSSTVPLGHSETHK--SAVETNTRRNTSTKGKK 814

  Fly   766 DETEISAMALQDVNSL-DNNQIEKTY--PSKPKLNVDVSEDISSR----------ESAIKSTSTK 817
            ...||    ||..::. ..:.:...|  |.:.|.:.:|..|:|::          |:.:.:...|
plant   815 KIKEI----LQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQNLLPAIPQAVEAIVDTEPVK 875

  Fly   818 NTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINYNEG---QWSPNNPSGKKQYDREQL 879
            |           :||    |.:|:.|:.........:.:|...|   :.|.|..:.:|:|.|:.|
plant   876 N-----------EPE----DWEDAADVSTPKLETADNSVNAKRGSSDEVSDNCINTEKKYSRDFL 925

  Fly   880 LQLREV-----KASRIQPEVKNVSIL-------------PQPNLM-------------PSFIRNN 913
            |:..::     :...:.|::.|..|:             |.|..:             ||.:..:
plant   926 LKFADLCTALPEGFDVSPDIANALIVAYMGASHHEHDSYPTPGKVMDRQASGARLDRRPSNVAGD 990

  Fly   914 NNNKRVQSMV--GIIGN--------------RSNESAGNYIGKQMSMSGVQSGGGRSS------- 955
            :...:.|..:  |..||              |:....|..|.:.|...|...|.||::
plant   991 DRWTKNQGSLPAGYGGNVGFRPGQGGNSGVLRNPRMQGPIISRPMQPVGPMGGMGRNTPDLERWQ 1055

  Fly   956 ------MKGMI---HVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDEL-VRRVRGIL 1010
                  .||:.   |..:                 :|::|::......:..::::. .|:::.||
plant  1056 RGSNFQQKGLFPSPHTPM-----------------QVMHKAERKYQVGTIADEEQAKQRQLKSIL 1103

  Fly  1011 NKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERM 1075
            |||||:.|:.|.|::..:.||....:..||..:|:||:.||.|...||..|..|:..:...:|..
plant  1104 NKLTPQNFEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFCFHLSGALPDFNENG 1168

  Fly  1076 ESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEER 1140
            |..|      |:..||:|.::||.:.     .||:         ::.:...|:.::|...||.|.
plant  1169 EKIT------FKRLLLNKCQEEFERG-----EKEE---------EEASRVAEEGQVEQTEEEREE 1213

  Fly  1141 K---IRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLL----NPHSEDMLECLCKLLTTVGAKFE 1198
            |   :|||..|.:|.||||:|..|||.||:::||..||    :||.|: :|.||||::|:|...:
plant  1214 KRLQVRRRMLGNIRLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEEN-IEALCKLMSTIGVMID 1277

  Fly  1199 KTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVIDLRKNKWQ-TSRNEAPK 1262
            .....       :.::....:|:.::.|.:     :||||||||.:.||||||||| ..:.|.||
plant  1278 HNKAK-------FQMDGYFEKMKMLSCKQE-----LSSRVRFMLINAIDLRKNKWQERMKVEGPK 1330

  Fly  1263 TMGQIEKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNG 1327
            .:.::.::|..|:.:     ..:..:.|.|...||:|        |....||..||
plant  1331 KIEEVHRDAAQERQT-----QANRLSRGPSMNSSGRR--------GHMEFSSPRGG--------- 1373

  Fly  1328 NLRHQQQNNVGGNVSGGA---GHSNG-------NNDENTWHVQTSKGSRSLAVDSNKLEGLSKLS 1382
                      ||.:|..|   |..:|       :|.:..:..:.|...|.:.:...      .:.
plant  1374 ----------GGMLSPPAAQMGSYHGPPQGRGFSNQDIRFDDRPSYEPRMVPMPQR------SVC 1422

  Fly  1383 DQNLETKKMGGLTQFIWI----------SSDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDR 1437
            ::.:.....|||.|.:.|          .||.|:.....:..|:.......|  .:.::.....|
plant  1423 EEPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGGDSRRPAGGLNGFGS--HRPASPVTHGR 1485

  Fly  1438 SGPRNKG-SYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQ 1501
            |.|:.:| :|         ..|...|.:.:|..|.|.||:|...||.:...:|.:::....:..:
plant  1486 SSPQERGTAY---------VHREFASLSRASDLSPEVSSARQVLQGPSATVNSPRENALSEEQLE 1541

  Fly  1502 ----QAPPTRHTVKAQSSVG--SSNVNTGPLYRGSEQQTSATFSQTTRS-----VAPVAVFIEAS 1555
                .|....::.:.::.:|  ..::|: |.|..:......|.|...:.     :|.:.|.:..|
plant  1542 NLSLSAIKEYYSARDENEIGMCMKDMNS-PAYHPTMISLWVTDSFERKDKERDLLAKLLVNLVKS 1605

  Fly  1556 E----TDLKLIKSVVSEIVDLSAASKEVTPGAVSCI-----KRVPEKLRCSFIYYILTDYLHLAN 1611
            .    .:::|:|...|.:..|..|..: .|.|...:     |.|.||:            :.|..
plant  1606 ADNALNEVQLVKGFESVLKTLEDAVND-APKAAEFLGRIFGKSVTEKV------------VTLTE 1657

  Fly  1612 VGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKIL 1676
            :|:            |||:.......|    .||.: ..|::..:.|:   |...||...:.:|.
plant  1658 IGR------------LIQEGGEEPGSL----IEFGL-GGDVLGSVLEM---IKTEAGEETLVEIR 1702

  Fly  1677 TISDLWNNNLKENSP--SNVAKKF 1698
            ..|.|...|.|.::|  |.:.:||
plant  1703 RSSGLRIENFKPHAPNRSKILEKF 1726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	86/254 (34%)
		MA3	1562..1677	CDD:280933	24/119 (20%)
		W2_eIF4G1_like	1764..1895	CDD:211397
EIF4G	NP_001078319.1	MIF4G	1096..1319	CDD:280935	86/255 (34%)
		MA3	1546..1654	CDD:295416	21/121 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101572
Panther	1	1.100	-	-	LDO	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1015
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870