DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and eif4g3b

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	XP_021325628.1	Gene:	eif4g3b / 568761	ZFINID:	ZDB-GENE-090312-49	Length:	1733	Species:	Danio rerio

Alignment Length:	1929	Identity:	487/1929 - (25%)
Similarity:	748/1929 - (38%)	Gaps:	583/1929 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 VSVNCVNTSKKYDFNNSSLLSNNSYPASTAEYVSTGNNNSGNT-----------RSNPQS----- 297
            |||:.|:|:..|..      .....|...:.|  |...|:|.|           .:.|||
Zfish   114 VSVSTVSTAHLYGH------PKGWEPGGGSPY--TTGQNAGTTPLVYSPTTQPMNAQPQSRPFAP 170

  Fly   298 --------GGIFRG----------------PPSTP------NAPRGASGGATRHVHVQPMYSQPL 332
                    || ||.                |.:||      ..|..|.....:|: :..|...|.
Zfish   171 GPRPTHHQGG-FRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHI-MMTMAHMPF 233

  Fly   333 HQNMVLQQY-TQYN-------------PRQQTFPASHLQYA-----PAPM----PYYQYQ----- 369
            |.....|.| .||.             |.|.|.|::....|     |||.    |||..|
Zfish   234 HSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVYTP 298

  Fly   370 ----YVPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGAS 430
                .|||.||.||..|...|:...       .|.|.|.:    |.....|.:.|..:...|
Zfish   299 SPPIIVPTPQQPPPAKREKKTIRIR-------DPNQGGKD----VTDEILSGVGLSRNPTPP--- 349

  Fly   431 TVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQP------------VQVQPASRRRHQHRLQIID 483
                ||.|.||    ..||..        :.|.|            :..|.|.   |.|.:..:|
Zfish   350 ----VGRPSST----PTPPQF--------LCPHPHYPHIFYLKSQQLNSQVAD---HGHIMYNVD 395

  Fly   484 PT----TKKNILDDFDKTKSNTDNEFSDQVTST---NTPATVLSEGPIRIPQQESVGLNNLTSTS 541
            .:    ...|:..| ||.|.    |||.|.|::   ..|.|.|..   |.|           |:.
Zfish   396 SSPHLPASFNLKAD-DKPKL----EFSLQRTASPGLRQPDTPLER---RDP-----------SSP 441

  Fly   542 SQGSESRTNAPYI-PIETTPISRTDVGPTPIVSAMT----DAPSVEILPTPQRGRSKKIPIVSPK 601
            .|...|..:.|.: |.::...|.....|||.:.|.|    ||||               |:..|
Zfish   442 VQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPS---------------PLAEP- 490

  Fly   602 NVSESIVAPITDETDDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLK 666
                |:...||.|.:.      |...:.|.||    |..|....::|::||:          ||.
Zfish   491 ----SLTKAITPEPES------SEPEKSSSPP----PQSLSGSLTQHEKAVN----------GLT 531

  Fly   667 EMHVAELESSVASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLD-- 729
            ::..|.|...          |:....::|..|..|:.|:         :.|..|:|:|.|..|
Zfish   532 DVDAAPLSEE----------LETQPREASPLLPTSSVPQ---------SEPRPVTPVLEEESDPI 577

  Fly   730 --NTEL-------------SKKLENSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVN 779
              |:.|             |..|..|||.....:.....|        ..:..:::|| || |..
Zfish   578 NMNSPLPPVEDDAGCPDNVSPSLSTSTTAAISTTPPAPPP--------GLSHPSQVSA-AL-DRR 632

  Fly   780 SLDNNQIEKTYPSKPKLNVDVSED-ISSRESAIKSTST-----KNTGVDVGLQSDSKPETTLNDK 838
            ..:..:|::|......|.....|. :.||:|:.::||:     |....|:.:..|..|     ||
Zfish   633 PSNGAEIKETGKENEALPDKRGEPFLQSRKSSNQATSSAPKTWKKPKEDMPVGQDQCP-----DK 692

  Fly   839 QDSTD---------------LKVKVSAKISSIINYNEGQW------------------------- 863
            ::.||               ::|:....:.:::..|..|.
Zfish   693 EEDTDQASMEPAPESPSPPPVEVERRPSVGAVLEENGEQEVEPLRNGAEHTSETESSDSIHPPAV 757

  Fly   864 ---------SPNNPSGKKQYDREQLLQLREVKASRIQPE----VKNVSI-------LPQ------ 902
                     .|...:|||||:|:.||..:.:.|...:||    :.:|.:       ||.
Zfish   758 KEPLIKVLPQPAEKNGKKQYNRDFLLGFQFMPACVQKPEGLPPISDVVLDKINQNKLPMRPVDPR 822

  Fly   903 -----PNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIHV 962
                 |:..|:|...:.         .|.|.|         |..:...|::...||.     |..
Zfish   823 VLSRGPDFTPAFADFSR---------PISGGR---------GAPLLNVGMRRPPGRK-----IIT 864

  Fly   963 NLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIK 1027
            |:|:..:|:|...||||:|.:  |.:|..:...|....||.|:||.|||||||:.|..|::::..
Zfish   865 NVSVIDEVQLKTTENAWKPGM--KREGAVEDPDAQRTQELFRKVRSILNKLTPQMFSQLMKQVTD 927

  Fly  1028 LKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAA-EVKVIDERMESETKSNS-AHFRNAL 1090
            |.|||.:::..||.|||||||:||:|||:|..:|..||. :|.:.|       |.|| .:||..|
Zfish   928 LTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLKVPMTD-------KPNSTVNFRKLL 985

  Fly  1091 LDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGE 1155
            |::.::||.::.....|.|||.:    :::..|.::|:..|:..|||.:.|.||||.|.::||||
Zfish   986 LNRCQKEFEKDKMDDDAFEKKHR----ELEAATASSERERLQEELEEAKDKARRRSIGNIKFIGE 1046

  Fly  1156 LFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRM 1220
            |||:.|||..|::.|:..||..|.|:.|||||:||||:|          ||    ...||:..||
Zfish  1047 LFKLRMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIG----------KD----LDFEKAKPRM 1097

  Fly  1221 QAIASKTDK--DGARVSSRVRFMLQDVIDLRKNKWQTSR-NEAPKTMGQIEKEAKNEQLSAQYFG 1282
            ....::.:|  ...:.|||:|||||||||||.:.|.:.| ::.|||:.||.|:||.|:..
Zfish  1098 DQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLHNWVSRRADQGPKTIEQIHKDAKLEEQE----- 1157

  Fly  1283 TLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGH 1347
                                      |.|.      .|.|.....|.|......
Zfish  1158 --------------------------EQRK------VHQQLLSKDNKRRPVVQR----------- 1179

  Fly  1348 SNGNNDENTWH-VQTSKGSRSLAVDSNKLEGLSKLS-DQNLETKKMGGLTQFIWI---------- 1400
                  |.||. |..:|.||:  :|..|:...||.: |:.::   :|...|..|:
Zfish  1180 ------EETWSTVPMTKNSRT--IDPAKIPKFSKPAIDEKIQ---LGPRAQVNWMKGSSGGAGAK 1233

  Fly  1401 --SSDTTRLS-SAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMH- 1461
              .||.:|.| |....:|..|.|:.:|.:...|.:.|    ..|..||  :||..|:|.|:.:.
Zfish  1234 ASESDASRPSASLNRYSPLQPSALQTSSLPSTSPDFD----SRRVLGS--RGSSGRERNDKPLSA 1292

  Fly  1462 --SRTGSSQGSRENS----------SSRGGQQGRT--LLSSSVQKSTSHSKYTQQAPPTRHTVKA 1512
              :|||....|..|.          |.|......|  ||.|:..||.     .:.:.|....||.
Zfish  1293 GPARTGPISLSSSNKETPEELVQEVSRRDSNASDTPKLLVSTADKSR-----LENSQPRESAVKL 1352

  Fly  1513 QSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASK 1577
            ::..|.|                           |....:...|.: :..||::.|.:.::...:
Zfish  1353 EALSGPS---------------------------PDKPALSEEEME-RRSKSIIDEFLHINDYKE 1389

  Fly  1578 EVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHL---- 1638
                 |:.|:    |:|..|.:.|:                ::.:.|...::::.|:.||:
Zfish  1390 -----ALQCV----EELEQSAMLYV----------------FVRVGVESTLERSQITRDHMGQLL 1429

  Fly  1639 ----------RL----AYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKEN 1689
                      :|    .::|....|:|:.:|||.:|||:.:...|::.:..:::.:|::...|..
Zfish  1430 FQLLQAGVLPKLQFFKGFSETLELADDMAIDIPHIWLYLAELVTPVLREGGISMRELFSEFSKPL 1494

  Fly  1690 SPSNVAKKFLKTYL-IYCTQ----EVGPNFARNMWIKFNLKWSDFMPESE-VADFIKFNRLEYVE 1748
            .|...|.......| :.|.|    :||     ::|....|.|:||:||:| |..||..::||:..
Zfish  1495 LPVGRAGILFSEILHLLCKQMSHKKVG-----SLWRDSGLSWADFIPETEDVHSFITEHKLEFTL 1554

  Fly  1749 NESKSP---VIDHRETPEKHVKNVIDHIEHLLKEGTTAD-CIIDYSNGNI---MVVDKLFIRGLT 1806
            ::..:|   |.....:||:..|    .:|.||.|....| .|.|:...|:   .:....|:|.|.
Zfish  1555 SDGSNPTEAVSKRTLSPEELNK----QLEKLLLEDMVGDEQIFDWVEANLDESEMSSAPFVRALM 1615

  Fly  1807 ETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSEL 1871
            ..:...::..:.:|.|::....|. .:|||.:|::|:.:.||:.||.||.|:..|:.|..||...
Zfish  1616 TAVCKAAVKTEGSSCKVDLSIIQT-RLPVLHKYLNSDTERQLQALYALQALIVKLDQPANLLRMF 1679

  Fly  1872 IGELYDAFVIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            ...|||..||.:::..||..|||  :..|||||:||:..||..|
Zfish  1680 FDCLYDEDVISEDAFYKWEVSKDPAEQQGKGVALKSVTAFFTWL 1723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	108/251 (43%)
		MA3	1562..1677	CDD:280933	24/132 (18%)
		W2_eIF4G1_like	1764..1895	CDD:211397	41/136 (30%)
eif4g3b	XP_021325628.1	Atrophin-1	<59..632	CDD:331285	147/648 (23%)
		MIF4G	903..1131	CDD:280935	108/252 (43%)
		MA3	1371..1482	CDD:280933	24/136 (18%)
		W2_eIF4G1_like	1569..1704	CDD:211397	43/139 (31%)
		W2	<1683..1729	CDD:327369	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm24848
orthoMCL	1	0.900	-	-		OOG6_101572
Panther	1	1.100	-	-	LDO	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970