Protein Alignment eIF4G1 and eif4g3a

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: XP_009304364.2
• Gene: eif4g3a / 566131
• ZFINID: ZDB-GENE-120810-2
• Length: 1714
• Species: Danio rerio
• Alignment Length: 1818
• Identity: 467/1818 - (25%)
• Similarity: 752/1818 - (41%)
• Gaps: 391/1818 - (21%)

  Fly   265 SSLLSNNSYPASTAEYV----STGNNNSGNTRSNPQSGGIFRGPPSTPNAPRGASGGATRHVHVQ 325
            |..||..|.||..:..:    .||.....|...|..|..:...|.:.|             ::||
Zfish   109 SPALSQVSVPAGPSYRILKPWETGGAPPYNPAQNAGSAPLVYSPQTQP-------------MNVQ 160

  Fly   326 PMY------SQPLHQNMVLQQYTQYNPRQQTFPASHLQYAP--------------------APMP 364
            |..      .:|.|...:  ..:|..|.:.|.|.::....|                    .|||
Zfish   161 PQTRPFVTGPRPTHHQFI--HRSQMQPARPTLPTNNPSIRPGSQTPTATVYPPNQPIMMTMTPMP 223

  Fly   365 Y----YQYQYVPTLQQQPPHTRSAVTVNTNVNVG----NNLQPVQSGPNGPLPVPGASSSQIQLL 421
            :    :|| |:|..:...|:            ||    ..:||..||...|.|.|....:
Zfish   224 FATQTHQY-YIPQYRHSAPY------------VGPPQQYAVQPPGSGTFYPGPSPAEYPT----- 270

  Fly   422 TSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASR-RRHQHRLQIIDPT 485
                 |.|:      ||....||...||...:      :.|.|:...|..| ::...:::|.||.
Zfish   271 -----PYAA------GPPYYTGQTVYPPSPPI------IVPAPMPPPPTKREKKPSSQIRIRDPN 318

  Fly   486 ------TKKNILDDFDKT----------------KSNTDNEFSDQVTSTNTPATVLSEGPIRIPQ 528
                  |::.:....:.|                .|:|....|.:::||.||    .:.|.....
Zfish   319 QGGKDITEEIMFGSRNPTPPAGHPASTLTPPAGRPSSTPTPPSGRLSSTPTP----PQRPSNCQT 379

  Fly   529 QESVGLNNLTSTSSQGSESRTNAPYIPI------ETTPISRTDVGPTPIVSAM------------ 575
            .|.....|.|...|:........|.:.|      |:.||.....||.|..|.:
Zfish   380 PEQTAYVNQTQRLSESPAPMDGKPSLAIDDRPKMESGPIKSISPGPRPSESCLEKREISSLPLLV 444

  Fly   576 TDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAP-----ITDETDDAGSTP----------ISR 625
            :.:|.|::...|..|..|......|:.:|.|....     |:.|.....::|          ::.
Zfish   445 SSSPEVDVSSHPTSGCIKPTAAGEPEFISPSATKAQTYQVISGEESVPEASPRLSASLSLRVVNG 509

  Fly   626 ATEESMPPNQTHPNL---LISDSSKHKQAVSNSEIS-KDAPTGLKEMHVAELESSVASENHPAGI 686
            ..|...|.:...|.:   |...||...|..|..|.| ::.|..|:|:....|.|..|......|:
Zfish   510 VNEPQTPSSYEEPEVQEALKMSSSCEIQGTSFMEESGQEVPVALEELQAEHLPSLAAHVPLIPGV 574

  Fly   687 LDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVL----------DNTEL-----SKK 736
            ...::..|:.|:             ::|  |..::|::..|:          |:.:|     |:.
Zfish   575 QASSITSSTTSV-------------LAP--PPGLAPLVQSVVLEVSEQNKTSDDVQLKAQDASES 624

  Fly   737 LENSTTERFKDSQSV-------EKPTHQELSLRNATDETEISAMALQDVNSLDNNQIEK---TYP 791
            ...|.:.:|..:|:|       :||..::|.:.....|.|....  :|.::.|...::.   ||.
Zfish   625 QTQSNSRKFTPAQAVPVVPKPWKKPNDEDLMMETLKKENEEETS--KDCSAGDEMVLQSSLGTYS 687

  Fly   792 SKPKLNVDVSEDISSRESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSII 856
            |  ...|...::..|.|:....|.....||:.                :|||..|.:.....|:.
Zfish   688 S--PFTVPEHQEKHSEENGETETEPFRNGVET----------------ESTDSGVTLGDSRGSMC 734

  Fly   857 N----YNEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPE-----------VKNVSILPQPNLM 906
            :    ..||....|   ||:||||:.||..:.:.|...:||           ..|.:.||..::.
Zfish   735 SPTQLIQEGLVQSN---GKRQYDRDFLLGFQFMPACVQKPEGLPPISDVVLDKMNQNKLPLRSVD 796

  Fly   907 PSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIHVNLSLNQDVK 971
            |..|....    .|.......:.|.:.||   |:...:..|:....|.     |.||||::.||:
Zfish   797 PRLISRGT----PQDFTPAFADFSRQMAG---GRGAPLLNVRRLPPRK-----IIVNLSVSDDVQ 849

  Fly   972 LSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKV 1036
            |.:.||||:|.:  |.:|.::....:...||.|:||.|||||||:.|..|::::..|.|:|.:::
Zfish   850 LKKAENAWKPGM--KREGVAEDPETIRTQELFRKVRSILNKLTPQMFHQLMKQVTDLTINTEERL 912

  Fly  1037 DEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQN 1101
            ..||.||||||||||:|||:||.:| |..|.:||    ..::..:.:.:||..||::.::||.::
Zfish   913 KGVIDLVFEKAIDEPSFSVAYANMC-RCLATLKV----PTADKPNTTVNFRKLLLNRCQKEFERD 972

  Fly  1102 VSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKI 1166
            .......|:|.:    :|...|...||..|:..|||.:.|.||||.|.::|||||||:.|||..|
Zfish   973 KVDDVVLERKQK----EIDSATSPTEKERLQEELEEAKDKARRRSTGNIKFIGELFKLKMLTEPI 1033

  Fly  1167 IYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDK-- 1229
            ::.|:..||..|.::.|||||:||||:|          ||    ...||:..||....::.:|
Zfish  1034 MHDCVVKLLKNHDDESLECLCRLLTTIG----------KD----LDFEKAKPRMDQYFNQMEKIV 1084

  Fly  1230 DGARVSSRVRFMLQDVIDLRKNKWQTSR-NEAPKTMGQIEKEAKNEQLSAQ---YFGTLSSTTPG 1290
            ...:.|||:|||||||||||.:.|.:.| ::.|||:.||.||||.|:...|   :...||....
Zfish  1085 KERKTSSRIRFMLQDVIDLRLHNWVSRRADQGPKTIEQIHKEAKLEEQEEQRKVHQQLLSKDMK- 1148

  Fly  1291 GSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGNNDEN 1355
                   :|.|:...|              |.|                              |.
Zfish  1149 -------RRPDQREQR--------------SMR------------------------------EE 1162

  Fly  1356 TWH-VQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIWI--------SSDTTRLSSAP 1411
            ||: |.|:|.||:  :|..|:..:||  .|..|..::|...|..|:        :||:....||.
Zfish  1163 TWNTVPTTKNSRT--IDPTKIPKISK--PQIDEKIQLGPRAQINWVKGSSGGAKASDSELTRSAG 1223

  Fly  1412 TPTPSNPFAVLSSLIDKNSNERDRDRSGPRNK-GSYNKGSMERDRYDRGMHSRTGSSQGSRENSS 1475
            . |.:...|:.||....:|.......|.||.. ||  :|||.|:|.::.:     |...||....
Zfish  1224 N-TLNRYSALQSSTSQSSSTPAQTSESEPRRSLGS--RGSMGRERSEKPV-----SLGPSRPGPF 1280

  Fly  1476 SRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTV-KAQSSVGSSNVNTGPLYRGSEQQTSATFS 1539
            .| |...:.|:.:.|.:.|     .::...:.||. ||..|.....:...   |.:|...|.|..
Zfish  1281 GR-GSSAKELIDNMVPEET-----RREGQDSHHTSRKASISEEKCEMENS---RSAESVKSETLL 1336

  Fly  1540 QTTRSVAPVAVFIEASETDL-KLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPE-KLRCSFIYYI 1602
            .:..|..||     .||.:: :..|:::.|.:.::...:     ||.|:..:.: .:.|.|:...
Zfish  1337 VSGVSEKPV-----LSEEEIERKSKAIIDEFLHINDYKE-----AVQCVLEIEQPSMLCVFVRMG 1391

  Fly  1603 LTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFA 1667
            |...|..:   ::.|.::.:...||||:..:....|...::|....|:|:.:|||.:|||:.:..
Zfish  1392 LESTLERS---QKAREHMGLLYYQLIQKGILPHSQLYKGFSEMLEQADDMAIDIPFIWLYLAELL 1453

  Fly  1668 GPLIVKKILTISDLWNNNLKENSP-SNVAKKFLKTYLIYCTQ----EVGPNFARNMWIKFNLKWS 1727
            .||:.:..:.:.:|::...|...| ...|..|.:...:.|.|    :||     ::|.:..|.|:
Zfish  1454 SPLLKEGGINMRELFSELSKPLLPVGRAAILFSEILHLLCKQMSHRKVG-----DLWRESGLNWA 1513

  Fly  1728 DFMPESE-VADFIKFNRLEYVENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTAD-CIIDYS 1790
            ||:||.| :..||..::||:..::. |||......|....:.:...:|.||.|..::| .|.|:.
Zfish  1514 DFLPEGEHLPAFISQHKLEFTVSDI-SPVSPASAKPSLSPEELFKQLEQLLLEDMSSDEQIFDWI 1577

  Fly  1791 NGNI---MVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLY 1852
            ..|:   .:....|:|.|...:...::..:..|.::::...|| .:|:|.:|.||:.:.||:.||
Zfish  1578 EANLDESQMSSSPFLRALMTAICKAAVKDESTSCRVDTAIIQK-RLPILHKYFDSDTERQLQALY 1641

  Fly  1853 TLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            .||.|:..|:.|..||......|||..||.:::..:|..|||  :..|||||:||:|.||..|
Zfish  1642 ALQSLIVALDQPPNLLRMFFDCLYDEDVISEDAFYQWETSKDPAEQLGKGVALKSVNAFFTWL 1704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830	35/178 (20%)
		YppG	322..>379	CDD:372950	17/86 (20%)
		MIF4G	1004..1252	CDD:397130	105/249 (42%)
		MA3	1562..1677	CDD:397128	26/115 (23%)
		W2_eIF4G1_like	1764..1895	CDD:211397	39/136 (29%)
eif4g3a	XP_009304364.2	None