Protein Alignment eIF4G1 and eif4g2

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: NP_001422978.1
• Gene: eif4g2 / 448460
• XenbaseID: XB-GENE-996465
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 1061
• Identity: 238/1061 - (22%)
• Similarity: 408/1061 - (38%)
• Gaps: 280/1061 - (26%)

  Fly   932 ESAGN--YIGKQMSMSGVQSG-GGRSSMKGMIHVNLSLNQDVKLSENENAWRPRVLNKSDGDSDA 993
            ::.||  |:||... .|||.. ..||:.:.:...|.|.|..:..||.|
 Frog    30 KTVGNSEYLGKTPG-PGVQRWVPSRSTKRDVNSTNNSANTAISSSEKE----------------- 76

  Fly   994 KSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYA 1058
                ..|.:.|:||||||||.||:||.|..|::.:.:||...:..||:|:.:||::||.:|..||
 Frog    77 ----RHDAIFRKVRGILNKLAPEKFDKLCLELLNVGVDTKLILKGVILLIVDKALEEPKYSSLYA 137

  Fly  1059 RLCQRLAAEVKVID----ERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKI 1119
            :||.|||.|....|    :....:.:|.:  ||..|:.|.:.||..........:|:..|::.:
 Frog   138 QLCLRLAEEAPNFDGPSTDGQPGQKQSTT--FRRLLISKLQDEFENRSRNVELYDKRDSPLLPE- 199

  Fly  1120 KKCTDANEKAELEAFLEEEERKIRR-RSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHS---- 1179
                            |||:|.|.: :..|.::|||||.|:.::...|::.||..||....
 Frog   200 ----------------EEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHRCIKALLEKKKRVQL 248

  Fly  1180 EDM---LECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFM 1241
            :||   |||||:::.|||.:.:.....|       .:::...||.|:  |.:|:   :.:|:||:
 Frog   249 KDMGEDLECLCQIMRTVGPRLDHEKAKS-------LMDQYFARMCAL--KANKE---LPARIRFL 301

  Fly  1242 LQDVIDLRKNKWQTSR---NEAPKTMGQIEKEA----------------KNE------------Q 1275
            |||.::||:|.|...:   :..|||:.||.::|                :|:            :
 Frog   302 LQDTMELRENTWVPRKAFIDNGPKTITQIRQDAVKDLGVFIPAPMSQGMRNDFFLDGPFMPPRMK 366

  Fly  1276 LSAQYFGTLSS---TTPGGSQG-GSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNN 1336
            |.....|.|:.   ..||...| |.|...||.:...|..|||..:      .|..|::....|:
 Frog   367 LERDPLGGLADMFRQMPGSGIGTGPGVIQDRFSPTMGRHRSSQLF------NGHGGHILPPTQS- 424

  Fly  1337 VGGNVSGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIWIS 1401
                                   |...||:...    |.:|.|:|...
 Frog   425 -----------------------QFEIGSKPFM----KSQGQSQLYQS----------------- 445

  Fly  1402 SDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGS 1466
                                 ..|:.:....:|..   ||   ...||.:..|...      ...
 Frog   446 ---------------------QGLLSQQGQSKDMP---PR---FIKKGQLNADEIS------LRP 477

  Fly  1467 SQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSE 1531
            :|....|.|.....|.:|::   :...|       |.||...|.:.........:...|
 Frog   478 AQSFLMNKSQVPKLQPQTMM---IPPRT-------QTPPMGQTPQLGLKTNPPPIQEKP------ 526

  Fly  1532 QQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIK--RVPEKL 1594
                   :::.:...|      :.|..:||.::.|:|.::...|:     .|::.:|  |.|:..
 Frog   527 -------AKSVKKPPP------SKEELIKLTEAFVTEYLNNGNAA-----DAINSVKEMRAPKHF 573

  Fly  1595 RCSFIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPEL 1659
            ....|..|:...|..::..|:   ..|..:..|.|:...::|:...|:.........|.||||.:
 Frog   574 IPEMISKIILQSLDRSDEDKE---KASALLGILRQEGVATSDNFMQAFLNILDQCPKLEVDIPLV 635

  Fly  1660 WLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWI---- 1720
            ..|:.|||...|:..::::|:|  ....||..       |....:.|.|::. ......|:
 Frog   636 KSYLAQFAARAIIADLVSLSEL--AQPLENGT-------LFPLFLLCLQQLA-KLGDREWLTDLF 690

  Fly  1721 ---KFNLKWSDFMPESEVADFIKFNRLEYVENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTT 1782
               |.|::  ..:||   .|..|...||.:|.:..|.:....:..::.:|.:        |...:
 Frog   691 QQSKINMQ--KMLPE---IDQNKDRMLEILEGKGLSFLFPLMKLEKELLKQI--------KMDPS 742

  Fly  1783 ADCIIDYSNGNI---MVVDKLFIR----GLTETLSNFSIHYKDNSY-------KLESE-----TF 1828
            ...|..:...||   :.:||.|:.    ...:.:||.:...:::..       :||.|     .|
 Frog   743 PQTIYKWIKDNISPKLHLDKGFVNILMTSFLQYISNEACPMEESDLSAAPSKEQLEQEKQLLLAF 807

  Fly  1829 QKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWR-DS 1892
            :    ||:|:::..:.|.|:..||.||:.......|:|:|.......||..:|::|:...|: |.
 Frog   808 K----PVMQKFLHDHVDLQVSALYALQVHCCSKNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDI 868

  Fly  1893 KDQSAGKGVAVKSLNPFFNSL 1913
            ..:..|||.|:..:|.:...|
 Frog   869 TQEFPGKGKALFQVNQWLTWL 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830
		YppG	322..>379	CDD:372950
		MIF4G	1004..1252	CDD:397130	84/259 (32%)
		MA3	1562..1677	CDD:397128	26/116 (22%)
		W2_eIF4G1_like	1764..1895	CDD:211397	32/150 (21%)
eif4g2	NP_001422978.1	MIF4G	82..311	CDD:397130	84/259 (32%)
		PRK12757	<437..>545	CDD:237191	25/186 (13%)
		MA3	540..653	CDD:214714	28/120 (23%)
		W2_eIF4G1_like	724..871	CDD:211397	32/158 (20%)